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Vitamin D functions as a hormone to help maintain bone integrity
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Calcium and Vitamin D have long been the favored micronutrient supplements grouped together to battle osteoporosis despite the well-known roles that vitamin K plays in bone metabolism. The efficacy of supplementation of vitamin k to combat osteoporosis remains debatable due to the conflicting results of various studies. The potential benefits of vitamin k supplementation for aided bone formation and reducing fracture risk are especially important to postmenopausal women due to the fact that they are the largest group with osteoporosis. Since vitamin K is often a minor subject in the topic of preventative measure for osteoporosis, it is necessary to first delve into how exactly it is involved with bones on the molecular level. After focusing on vitamin K in the micro scale, research articles focusing directly on the potential positive effects of vitamin K supplementation in the postmenopausal target range will be analyzed. Following the discussion concentrating solely on vitamin K, the relationships between vitamin k and the other nutrients involved in bone health will be called into question. Regardless of the controversy and debates about supplementing vitamin K, it will be shown to be beneficial for fighting the onset of osteoporosis in postmenopausal women.
Vitamin K is a fat soluble vitamin that was believed at the time at the time of its discovery to only influence blood coagulation. Since then our knowledge on the vitamin, or group of vitamins, has drastically expanded. It is now known that vitamin K is an important cofactor in the activation of proteins belonging to the gla family (1. Vermeer C. ). Roughly 17 gla proteins have been discovered, among them being prothrombin, osteocalcin, and matrix gla-protein. Pro...
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...on and some research needs to be done to smooth out the edges but the potential for halting osteoporosis is still there. It can often be hard to tell if someone is vitamin K deficient after menopause especially since there is a decrees in osteocalcin carboxylation. The low amount could be from the diet, poor intestine absorption, or maybe even a need for a higher RDA for older populations. There are likely multiple reasons causing the osteoporosis is a person, so removing one of the problems with adequate vitamin K will surely help. There were two studies showing the benefits of Vitamin K1 and K2 as well as the usefulness of a vitamin K supplement in a group package so that it works to its fullest capacity. It has a long way to go but supplementation of Vitamin K1 and K2 have the definite possibility to halt the onset of osteoporosis in postmenopausal women.
Her findings from this research was praised as she concluded that small supplementary feeding with fruits, milk and wheat germ improved the growth of school children. She also found out that the over dosage of Vitamin D produced brittle bones and calcification of soft tissues. If that wasn’t enough, she continued her extensive research and showed that pantothenic acid is essential for normal pigmentation of hair and skin. Lastly she was intelligent enough to prove that the bone density of woman decreased between 50 and 65 years of
Vitamin B12 deficiency limits selenium methylation and excretion resulting in higher tissue selenium levels and subsequent toxicity. It occurs in people whose digestive systems do not adequately absorb the vitamin from the foods they eat. Vegetarians who eat eggs and milk products are the most at risk because, on average, they consume less than half the adult vitamin B12 Recommended Dietary Allowance (RDA) while strict vegans (who don't eat any animal products, including meat, eggs, or milk) are at an even greater risk. Vitamin B12 is important since it works with the vitamin folate to make the body’s genetic material and help keep levels of the amino acid homocysteine in check which helps to decrease heart disease risk. It is also essential in the production of red blood cells which carry oxygen through the blood to the body’s tissues. Life Extension gives offers some of selenium supplements. Babies who are born of parents with low selenium and vitamin B12 rich foods are at risk of anaemia.
(13) Pazirandeh S. Overview of vitamin K. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed 27th April 2014)
UV exposure to skin can generate reactive oxygen species (ROS) that cause direct chemical alteration in collagen and increase matrix metalloproteinase (MMP) production leading to collagen break down. In addition, ROS produce mediators that cause skin inflammation. Vitamin C neutralizes ROS and is equally effective against UVA (320-400nm) and UVB (290-320 nm) that are produced due to UV exposure and causes skin-aging and sunburns respectively. Vitamin C is most effective as it exerts its action interacellularly and extracellularly (7).
Osteoporosis is a condition, in which bones are weak from deterioration, loss of bone mass, and quality-bone strength. Osteoporosis usually triggers postmenopausal women (women who have not had their period for a whole year), or older men and women. Some risks both older men and women endure when experiencing Osteoporosis are decrease of calcium and bone fractures. These symptoms or effects can all be caused by weight loss, smoking, age, ethnicity, genetics, medications, bone structure, and certain diseases that can later on contribute to Osteoporosis, such as rheumatoid arthritis. Osteoporosis may be prevented by going to drug therapy to stop alcoholism and smoking, a sufficient amount of calcium intake, and exercising; such as jogging, walking,
First of all, being a woman is one of the risk factors of osteoporosis especially after the age of menopause. “30% of American women between the ages of 60 and 70 have osteoporosis” (Marieb & Hoehn, 2016).To clarify, menopause is characterized by the loss of estrogen hormone production by the ovaries. Since estrogen is necessary for osteoblast to build new bone tissues, the lack of this hormone will improve the ability of osteoblast to absorb the bone tissues. Another risk factor of osteoporosis is being Caucasian. Caucasian women are more likely to get osteoporosis. 30% of Caucasian women experience a bone fracture in their lives that is related to osteoporosis” (Marieb & Hohen, 2016) . Furthermore, genetics are another risk factor of osteoporosis. Individuals with a family history of osteoporosis are at a primary risk for developing this condition. Moreover, a bad and unhealthy lifestyle including poor diet, lack of activities and exercise, smoking, and drinking too much are also risks factors of osteoporosis. In addition, low body weight is another risk factor of osteoporosis. Individuals with low body weight and small amount of fat and muscles are more likely to get this
Osteoporosis is a systemic, debilitating disease of the skeleton, characterized by significantly decreased bone mass in combination with the deterioration of bone microarchitecture. Osteoporosis has three types of categories the first category is type 1 which occurs in women after menopause and results from declining levels of estrogen and other sex hormones in the body, this could also occur in men due to low levels of the sex hormone testosterone. Type 2 is called Senile Osteoporosis, which occurs in elderly men as well as elderly women because of decreased bone formation due to aging. Type 3 is caused by long term use of medication usually with steroids and drugs to treat elipsy. Osteoporosis which literally means “Porous Bone”,
Osteoporosis is one of the main types of bone diseases that is more commonly developed in the adult years of men and women, but can also affect younger aged people too. This disease contributes to “…decrease bone mass, increased skeletal fragility, and an increased risk of fractures…” (Caple & Schub. 2014). Bones are constantly being replaced by new bone hence it is living tissue. Osteoporosis eventually occurs when new bone has failed to be developed. In Canada, “1.5 million Canadians 40 years of age or older (10%) reported having been diagnosed with osteoporosis, of which, women were 4 times more likely to report having osteoporosis than men” (“What is the impact,” 2010). Women are at greater risk then men because the hormone changes in women can affect the bone density. Estrogen is essential for bone density but after menopause the levels fall resulting in bone loss. On the other hand, the cause for men is still unknown. However, testosterone: the male hormone helps to keep bones healthy. Even though men still produce the male hormone at an old age, there is still a risk of osteoporosis because the levels have dropped. Occasionally bone loss occurs without any cause, and later realizing that it is a silent theif when you ultimately develop symptoms (“Osteoporosis – Review,” 2014). In most instances osteoporosis is preventable, even though it is not reversible and harmful disease.
Women are at a higher threat of developing osteoporosis when their ovaries discontinue producing estrogen. This is due to the fact that estrogen supports maintaining proper calcium levels in bones. “A collapse of bony vertebrae of the spinal column results in loss of height and stooped posture. Hip fractures are a common occurrence.”
Osteoporosis comes from the latin word meaning “porous bone”. If you were to look closely at a bone you could see there are these small spaces on the bone which is good, now if you look at someone who suffers from osteoporosis you will see these spaces are much larger. As these spaces become larger it takes away from the strength and integrity of the bone making it grow weak and thin. Osteoporosis is most common in women over the age of 50 and gives them a higher risk of fractures and or breaks especially common in the hips. While we know osteoporosis comes from a number of things it can be broken down to age, the hormonal changes most commonly seen in menopause and a lower intake of Vitamin D and Calcium. Age is the unpreventable factor that doctors or you cannot change. Hormonal changes can be fixed with supplements or hormone therapy along with ones intake of Vitamin D and Calcium. Hormone therapy, estrogen alone or the combination of estrogen and progestin have been proven to prevent and aide in the treatment of osteoporosis in
Vitamin B12 is an essential nutrient that plays an important role in DNA synthesis and nerve function. It is contained in high amounts in animal derived foods such as milk, eggs, and meat. The vitamin is stored in the liver long-term. Individuals with vegetarian, vegan, or other forms of restricted diet may develop the condition after approximately 6 months as liver stores of vitamin B12 become depleted. Some individuals develop the condition due to autoimmune destruction of cells in the stomach that produce intrinsic factor. Intrinsic factor is necessary for proper absorption of vitamin B12 in the small intestine.
Having a good health is a very important, but most people do not realize about it. Even if they do, they may still disregard it. We need good health in order to do any activity. To have a good health we need to eat a healthy food. Our body needs a sufficient water and healthy food that covered five classes of food which consist of carbohydrates, protein, fruit and vegetable, and fats. However, people nowadays always put their career as their priority and do not take care about their health. Sales of product such as vitamin supplements to get a healthy body and skin becomes more popular and trending. Some people are willing to buy it because they want to get a faster result of their body and there are also people who feels it is a must to take vitamin supplements in their life. Nevertheless, some people consume and relying too much vitamin supplement each day and there are various effects from it which are laziness and toxicity.
Steps that you can take to reduce the chances of getting osteoporosis is consuming at least 3 portions of milk and dairy produce that have reduced fat content. You should also choose vegetables that are high in calcium such as broccoli and cabbage. Another recommendation is try to moderate the amount of alcohol you intake because alcohol can affect the liver which is important with using vitamin D in your body. You should also try to watch how much coffee and soft drinks that you consume a day because they can decrease the amount of calcium absorption which can cause bone loss. You should try to avoid eating lot of salty foods because they can cause your body to lose calcium from the sodium that is within it which can lead to bone loss. Other factors that can help you avoid getting osteoporosis is getting enough physical exercise such as sports and working out because that can improve strengthening your bones, eating fish such as salmon and at least once a week and eating vegetables and fruits at least five times daily because they help get the different nutrients that your body needs to keep it healthy. Smoking also can cause bones to become brittle because it affects your bone density but also affects your lungs which makes it harder to breath which can also can make them to do less physical activities and can also cause them to have poor
Investigation into the effect of storage or cooking on the vitamin C content of a food substance:
Vitamin E is the general classification for a group of eight fat-soluble compounds of tocopherols and tocotrienols. Vitamin E functions primarily as an antioxidant, but also has other roles in the body [1].