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Penicillin in pharmacology
Penicillin and its impact on treating disease
Penicillin and its impact on treating disease
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Staph was discovered in the 1860 by a Scottish surgeon named Sir Alexander Ogston. He worked on wounds and surgery and put carbolic acid on the wound after surgery to keep it getting infected. In the year 1881 there are two kinds of staph infections you can either see yellow grapes or white grapes. In 1941 eighty-one percent of the patients died that year from staph infections and In 1940s the penicillin stopped curing staph infections because it came resistant penicillin. In 1961 MRSA was detected in a British hospital it is a staph infection that no medicine can cure.
The scientific word for a staph infection is staphylococcus aureus. In Greek staphylo means cluster or bunch of grapes, the word coccus is a round bacterium, and aureus is a Latin word for gold. Sir Alexander Ogston name the infection this because, when you look under a microscope it looks like a cluster of grapes on a vine. When doctors go look under the microscope they use test gram stain to see what kind of staph infection you have.
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Everyone has a little bit of staph germs in their body, it is normally in your nose or on your skin.
You can get a staph infection by direct contact. For most people staph infection just gets into the skin by a scratch. A staph infection looks like a spider bite at first. Then it starts to get bigger and could form a boil or can form a scalded skin syndrome. A staph infection can be much worse if you get it inside the body. It can cause back pain, limps, and bone pain. You can also get a staph infection in your lungs it a form of pneumonia. This is very fatal in about fifty percent of the cases. Staph infections can cause more extensions of disease like toxic shock syndrome, skin infections, gastroenteritis, and thrombophlebitis all of those could potentially lead to
death. MRSA is a staph infection that is resistant to all antibiotics like, penicillin, methicillin, and oxacillin. They have considered it to be a superbug. A super bug is known as an infection that is resistant to all antibiotics that are normally used. MRSA is infections usually occur when you are in the hospital or nursing homes. There are many treatments for a staph infections other than MRSA. The treatment for a staph depends on where your infection is located and how bad it is. If it just small skin infection in can be treated by a prescription cream form your doctor or you can take an antibiotic. If it is in between minor and severe your doctor will treat you and drain the liquid. If it is severe. You can try penicillinase but that has become resistant to most people. Or you can try any of these antibiotics vancomycin, clindamycin, or IV vancomycin. The best way to prevent a staph infection is good personal hygiene and to keep a band aid covered over you cuts because, one germ can cause 30 different types of infections.
After the end of the experiment the unknown 10 sample was Staphylococcus epidermidis. Came to this conclusion by first beginning with a Gram Stain test. By doing this test it would be easier to determine which route to take on the man made flow chart. Gram positive and gram negative bacteria have a set of different tests to help determine the unknown bacterium. Based on the different tests that were conducted in lab during the semester it was determined that the blood agar, MSA, and catalase test are used for gram positive bacteria while Macconkey, EMB, TSI, and citrate tests are used for gram negative bacteria. The results of the gram stain test were cocci and purple. This indicated that the unknown bacteria were gram positive. The gram stain test eliminated Escherichia coli, Klebsiella pneumonia, Salmonella enterica, and Yersinia enterocolitica as choices because these bacteria are gram negative. Next a Blood Agar plate was used because in order to do a MSA or a Catalase test there needs to be a colony of the bacteria. The result of the Blood Agar plate was nonhemolytic. This indicated that there was no lysis of red blood cells. By looking at the plate there was no change in the medium. Next an MSA test was done and the results showed that there was growth but no color change. This illustrates that the unkown bacteria could tolerate high salt concentration but not ferment mannitol. The MSA plate eliminated Streptococcus pneumonia and Streptococcus pyogenes as choices since the bacteria can’t grow in high salt concentration. Staphylococcus aureus could be eliminated because not only did the unknown bacteria grow but also it didn’t change color to yellow. Lastly a Catalase test was done by taking a colony from the Blood Agar plate...
Streptococcus pyogenes is a very common bacteria found in humans. It is very transmissible and can be caught through the air via coughing or sneezing. This form of Strep. illness is referred to as Streptococcal pharyngitis, also known as Strep. throat, which can complicate into Scarlet Fever. It is also possible to be infected through abrasions of the skin, which can result in cellulitis, impetigo, or even necrotizing fasciitis. Aside from human to human contact, these bacteria can also be found in unpasteurized milk. There is no vaccine for Streptococcal infections, though antibiotics such as penicillin still work very well against them.
Staphylococcus epidermidis is classified as a bacterium. This particular bacterium is identified in laboratory testing by its forms of clusters and a violet stain. The violet stain indicates that the staphylococcus epidermidis is gram- positive meaning that it is sphere shaped and does not contain an outer cell membran). This type of Staphylococcus does not typically cause disease in healthy people.
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
A remarkable breakthrough in medicine occurred in the late 1800s through the work of Louis Pasteur. Pasteur's experiments showed that bacteria reproduce like other living things and travel from place to place. Using the results of his findings, he developed pasteurization, which is the process of heating liquids to kill bacteria and prevent fermentation. He also produced an anthrax vaccine as well as a way to weaken the rabies virus. After studying Pasteur's work, Joseph Lister developed antisepsis, which is the process of killing disease-causing germs. In 1865 before an operation, he cleansed a leg wound first with carbolic acid, and performed the surgery with sterilized (by heat) instruments. The wound healed, and the patient survived. Prior to surgery, the patient would've needed an amputation. However, by incorporating these antiseptic procedures in all of his surgeries, he decreased postoperative deaths. The use of antiseptics eventually helped reduce bacterial infection not only in surgery but also in childbirth and in the treatment of battle wounds. Another man that made discoveries that reinforced those of Pasteur's was Robert Koch. Robert Koch isolated the germ that causes tuberculosis, identified the germ responsible for Asiatic cholera, and developed sanitary measures to prevent disease. (1)
Facts of the victim’s case are laid out one by one, as if clues to a whodunit game where the culprit is ubiquitous MRSA. Descriptions are lengthy and vivid, describing everything from the patient’s painful symptoms to gruesome surgical procedures that will upset even the toughest of stomachs. This is definitely not the book to read before a large meal. The book reads like an episode of Frontline, keeping the reader on the edge of their seat until the end.
A common healthcare acquired infection that is seen both inside and outside of the hospital is methicillin-resistant Staphylococcus aureus (MRSA). MRSA can have detrimental effects on the patient and is usually acquired within the hospital setting. The PICOT statement has many important aspects to include such as: population, intervention, comparison, outcome, and time, which is used to produce an evidence-based question. According to Schmidt & Brown (2012), the PICOT statement is used in evidence-based practice is to make decisions about patient care based on evidence with clinical expertise appraisal and current research while also considering patient preferences and values. The PICOT statement: In patients between the ages of 30 and 70 admitted
Centuries later, another man began to outline more thoroughly the features and symptoms of several afflictions. Theodor Billroth, a Viennese surgeon described streptococci, staphylococci, diplococci, and even rods found in pus as intervals regarded in a distinct species: Coccobacteria septica (Breed). He investigated the roles of the bacteria and entwined their origin. Billroth noticed specific bacteria in those with erysipelas; he named the bacteria streptococcus from the two Greek words strepto meaning a chain formed of links, and coccus meaning berry.
We have all heard of, and possibly have had at least once on our lives strep throat. Strep throat is a bacterial infection in the throat and the tonsils. The throat gets irritated and inflamed, causing a sudden, severe sore throat. Strep throat is caused by streptococcal (strep) bacteria. There are many different types of strep bacteria. Some cause more serious illness than others.
What is Strep Throat you ask? Strep throat is a sore throat with fever caused by streptococcal infection. Sore throats are most commonly caused by viral infections or other irritants such as smoke, allergies, dry air, or a throat injury, and not by a strep infection. A strep infection causes the throat (pharynx) and the tonsils or adenoids to become irritated, inflamed, and painful. Strep throat is caused by streptococcal (strep) bacteria, most often by group A beta-hemolytic streptococcus (GABS). Other types of strep that can sometimes infect the throat are groups C and G strep bacteria. How the strep infection is spread? Strep throat can be passed from person to person. When a person infected with strep throat breathes, coughs, or sneezes, tiny droplets containing the strep bacteria are released into the air and are breathed in by other people.
One of the ways to get necrotizing fasciitis is to have the bacteria get into your body through a cut on your body. This is how the majority of people get necrotizing fasciitis. It can be just a papercut, but if you do not take care of it, you could have severe consequences. You are also more likely and at risk to get necrotizing fasciitis if your body does not have a strong immune system.
Even though S. aureus is mainly associated with food poisoning, the bacterium can penetrate the skin or other mucous membranes to invade a range of tissues which will cause a variety of infections. Superficial infection of the skin can cause boils, impetigo, styes (infection of the glands or hair follicles of the eyelids), folliculitis, and furnacles. All of these infections are charac...
Cellulitis is an acute spreading bacterial infection of the connective tissue, dermis and subcutaneous layers of the skin (ProQuest 07/2012 pg.5). Characterized by redness, swelling, warmth, tight/shiny skin and pain. It is sometimes accompanied by fever, swollen lymph nodes, chills and fatigue. Cellulitis first appears on pink-to-red minimally inflamed skin. The area of infection rapidly becomes deeper red and increases in size as the infection spreads. Occasionally, red streaks may radiate outward from cellulitis. Blisters or pus filled bumps may also be present (skinsight 12/2012 pg.5). The main culprit is the bacteria Streptococcus and Staphylococcus which can enter through a break in the skin.
Chicken pox is not an Entrée that is served at one’s family holiday dinner party. Chicken pox is an extremely contagious disease caused by the Varicella zoster virus. Chicken Pox is not a disease that is known to affect other animals or insects. Unlike other diseases, where human and other animal close interaction causes the exchange of virus and disease this disease did not come from a human-chicken interaction. The name chicken pox has been stuck for generations; there are many theories behind its name. Chicken pox could sneak up on its young victims in the form of an innocent touch, or by inhaling tiny particles from a cough, or sneeze which then enters the respiratory tract. Once the virus attaches itself to it gracious, and unwilling host cells it causes a crimson rash that could be located on different parts of the body. The rash is highly irritating which makes it almost impossible not scratch. In the United States each year about 5,000 to 9,000 people are hospitalized, and around 100 people die from the microbe Varicella zoster that causes chicken pox.
Engelkirk & Burton (1979) state that bacteria can reproduce asexually by simple division of cells and some bacteria reproduce sexually by conjunction. A bacterium is a waste producer of products and secretions. This allows pathogens to invade their hosts to cause disease some of these harmful diseases are Scarlet fever, an acute illness, characterized by a reddish skin rash, which is caused by systematic infection with the bacterium streptococcus. St. Anthony’s Fire is another bacterial disease. “St. Anthony’s Fire which is an acute superficial form of celluitus involving the dermal lymphatic, usually caused by infection with streptococci and chiefly characterized by a peripherally spreading hot, bright red, oedematous.