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Penicillin was one of the very first antibiotics. It is often referred to as "the miracle drug" because of its effectiveness against many harmful and deadly bacteria. With its discovery by Alexander Fleming in 1928, penicillin has proven to be a major contribution to the medical field. Penicillin is responsible for preventing the spreading of infectious illnesses, and for improving military medicine. It has revolutionized the study of medicine, saved countless of lives, and played a key role as a foundation for the development of other efficient antibiotics. The discovery of penicillin has greatly improved the way doctors were able to treat patients and gave way to a new era of antibiotics.
History
Prior to the discovery of penicillin, scientists had various ideas about bacteria, or rather the existence of it, and how disease should be treated. Doctors in the early 19th century had a hard time accepting that disease was caused by something that they could not see with their own eyes. Alexander Gordon recommended in 1795 to wash the surgeon's hands and person before operating on anyone. In 1843, Oliver Wendell Holmes, a Boston physician and Harvard anatomy professor wrote that an operator should wash their hands with chlorinated water and change their clothes. However, both of these recommendations were ignored by surgeons and patients continued to die of infections.
Disease has been treated in various methods over many centuries. One of them was through vaccinations. For many years, it's been observed that dairy maids rarely got sick with smallpox. This intrigued Edward Jenner, an English country doctor in the 1770's, and he decided to investigate. He saw that milk maids didn't get smallpox. Instead, they caught cowpox, a r...
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... by a secretary on a cantaloupe in a local market. By the time the US had entered the war, 21 chemical companies were producing penicillin. When the war ended, these companies were making 650 billion units a month.
Conclusion
Fleming and Florey were knighted for their deeds in 1944. They, plus Chain were awarded the Nobel Prize in Medicine in 1945. Penicillin was, essentially, a gateway for modern medicine. It paved a road for future antibiotics and improved the chance of living for patients undergoing surgery. It also lowered the amount of infections in the operating room. The discovery and production of penicillin introduced many new methods for the production of medicine. It has controlled many bacteria, which without penicillin, would have been deadly to humans. With penicillin, the medical field had made great leaps which would have been impossible before.
The Factor of War in the Development of Penicillin The discovery, development and subsequent use of penicillin can be considered to be one of the most important breakthroughs in medical history. There were many factors, which were involved in the development of penicillin, and it could be argued that war was the most important, but other factors were also responsible. Alexander Fleming was working in London as a bacteriologist in 1928 when he noticed that a growth of a mould called penicillin produced a substance that actually killed the germs he was working on. He realised that this might be very important and a year later he wrote an article about his findings. However, Fleming did not have the facilities or the support to develop and test his idea that penicillin could fight infection, and he didn't develop it further.
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
A remarkable breakthrough in medicine occurred in the late 1800s through the work of Louis Pasteur. Pasteur's experiments showed that bacteria reproduce like other living things and travel from place to place. Using the results of his findings, he developed pasteurization, which is the process of heating liquids to kill bacteria and prevent fermentation. He also produced an anthrax vaccine as well as a way to weaken the rabies virus. After studying Pasteur's work, Joseph Lister developed antisepsis, which is the process of killing disease-causing germs. In 1865 before an operation, he cleansed a leg wound first with carbolic acid, and performed the surgery with sterilized (by heat) instruments. The wound healed, and the patient survived. Prior to surgery, the patient would've needed an amputation. However, by incorporating these antiseptic procedures in all of his surgeries, he decreased postoperative deaths. The use of antiseptics eventually helped reduce bacterial infection not only in surgery but also in childbirth and in the treatment of battle wounds. Another man that made discoveries that reinforced those of Pasteur's was Robert Koch. Robert Koch isolated the germ that causes tuberculosis, identified the germ responsible for Asiatic cholera, and developed sanitary measures to prevent disease. (1)
Only simple operations were possible because there were no blood transfusions, and patients often died from infection. But in 1825 little had changed. A vaccination had been developed for smallpox, but there were no other vaccinations or drugs b... ... middle of paper ... ... ‘Peterloo Masacre’.
Most of these medical advances were a result and were an influence of World War I. Probably one of the most important medical advances was the discovery of penicillin in 1928 by a Scottish, microbiologist named Alexander Fleming, he had actually accidently discovered it, when he noticed that a bacteria culture he had been growing, had stopped, he realized that it had been contaminated by a rare form of mold called Penicillin and that it had killed the bacteria.
By preserving the virus, Boylston personally inoculated 247 people in 1721 and 1722 to prevent transmission. However, from there only six people died, and Boylston was the first American surgeon to inoculate his patients personally. The author portrays the background data Boylston used to examine the inoculation practice on different age and gender of persons to treat his patients from previous experiments. The inoculation method provided higher level of immunity in preventing smallpox infection. The prevention of smallpox is through inducing antibodies through vaccines which last longer for a person taking it.
During one of his earlier apprenticeships, Jenner noticed milkmaids with a disease called cowpox. Cowpox is a close relative to smallpox and is only mild in humans. Pustules appear on the hands and a basic cold is also brought on. At Jenner’s young age he was able to link these two viruses together and come up with a theory for immunization. In 1796, while still attending medical school, Jenner decided to test this theory between smallpox and cowpox. He used a dairymaid, who was a patient of his named Sarah Nelms, who had contracted cowpox and had ripe pustules on her hands. Jenner realized this was his opportunity to test someone who had not contracted smallpox yet. He picked an eight-year old boy named James Phipps to use as his test subject. He scraped open a spot of James' arm and rubbed in a dissected piece of Sarah Nelms pustule into the open wound. A couple days later James became ill with cowpox but was well again within a week. This test proved that cowpox could be spread between humans as well as cows. Jenner's next test would be if the cowpox virus gave James immunity against smallpox. On July 1st of 1796, Edward Jenner obtained an infected smallpox pustule and scratched the virus filled pus into James' arm. This technique of placing a virus into a patient is called variolation. James Phipps did not develop smallpox within the
Edward Jenner invented a method to protect against smallpox in the late 1700s. The method involved taking substances from an open wound of someone with small-pox or cow-pox and injecting it into another person’s skin, also called “arm-to-arm inoculation”. The earliest actual documented examples of vaccination date all the way back to the tenth century in China (Lombard, “A brief history of vaccines and vaccinations”). The mention of early vaccination was taken note of by a French scholar, Henri Husson, written in one of his journals (Dictionaire des sciences médicale). The Ottoman Empire Turks also discovered a method of immunization a few centuries later. Lady Montagu of Great Britain, a famous writer and wife of the English ambassador of Istanbul, between 1716 -1718, came across the Turkish vaccine for small-pox. After surviving as a child with small-pox, she insisted her son be vaccinated (Henricy, “Letters of the Right Honourable Lady Wortley Montagu”). When she returned to England, she continued to publicize the Turkish tradition of immunization and spread their methods to the rest of her country. She also had all family members also vaccinated. Immunization was soon adopted in England, nearly 50 years before Jenner's smallpox vaccine in 1796 (Sharp, “Anti-vaccinationists past and present”). Edward Jenner’s target for smallpox was to eradicate it. And later by the 1940s, knowledge of the science behind vaccines had developed and soon reached the point where across-the-board vaccine production was a goal that was possible and where serious disease control efforts could start. Vaccines for many dangerous diseases, including ones protecting against pertussis, diphtheria, and tetanus were underway into production. ...
For approximately three-thousand years, smallpox has ravaged and plagued the four corners of the globe. In fact, in the 17 th and 18 th centuries, it was claimed to be the most infectious disease in the West, with an astounding 90% mortality rate in America. It wasn't until 1796, with English surgeon Edward Jenner's smallpox vaccination, that the world saw relief from this devastating virus. However, even with this inoculation in use, the world continued to witness death from both the virus and the vaccine. In the year 1966, it was estimated that 10-15 million infected citizens world wide had passed away from smallpox that year alone ( “History” 12). As a result of these devastating numbers, in the following year, 1967, the World Health Organization (W.H.O.) created a program to eradicate the smallpox virus. Ten years later, in 1977, the estimated 10-15 million cases had dwindled down to one; a man in Somalia. Three years later, W.H.O. officially announced that smallpox had been eradicated, leaving the only remaining virus cultures stored and guarded in laboratories in Russia and the United States. Inoculations ceased, smallpox epidemics were non-existent, and the virus was no longer a concern. In order to ensure complete eradication of this deadly virus, the W.H.O. insisted that the remaining smallpox cultures be destroyed by 1999 ( “Smallpox Eradication” 2). However, despite the W.H.O.'s recommendation, the remaining cultures continue to be contained and protected to this day, five years after the suggested date of elimination.
Illness has been a major part of humankind’s lives almost since the beginning of time. Throughout history, illnesses caused fatal epidemics that caused deaths between young and old, and brought fear upon all for the absence of a cure. Having an illness throughout most of history was considered an inevitable death sentence, as the majority of causes of death (Offit). Vaccinations have been experimented in China and Turkey in the 15th century, with methods such as inhaling or rubbing grounded up smallpox scabs against open cuts (Clem). Then in 1700s, the first form of modern vaccination was invented by Edward Jenner with the cowpox virus acting against smallpox, giving immunity against it (Offit).
Alexander Fleming started the history of antibiotics in the 1920's with his discovery of penicillin.When penicillin was first discovered and used widely, it was touted as a wonder drug, and consequently was used as one.Though not necessarily harmful to the patient penicillin was used for much more infections than it was able to combat.Today the same practice is observed in the medical profession, however at this point it is due more to the detriment of an uneducated public.Studies have been carried out that show the huge over usage of antibiotics.In the seventies Soyka et al, concluded, "60% of physicians surveyed gave antibiotics for the treatment of the common cold."[3], and by common knowledge the common cold is a virus, something that cannot be treated by an antibiotic.Nyquist
...ing sealed his place in history with the discovery of lysozyme, it was his discover of Penicillin in 1928 that started the revolution of antibiotics and sealed his lasting reputation within the medical world. In 1945, Fleming was recognized for his achievements and he reached the Nobel Prize for Physiology. On March 11, 1955, Fleming died in London, England. (Brown, 2013)
At his Nobel Peace Prize speech in 1945, Alexander Fleming warned against the misuse of antibiotics and the fact that by doing this, one allows the bacteria to ‘become educated’ and therefore become resistant to the antibiotic. It is believed that the first cases of antibiotic resistance were shortly after this speech. (Fleming, 1945)
Vaccines were first invented by Edward Jenner in 1796 to protect against smallpox, which involve...
The First World War of 1914 through 1918 was the beginning of new era of medical innovations and advancements that were infrequently glorified and somewhat held in high prestige. Beginning in the earlier stages of the war, there was uncertainty in hygienic medical practices and education through notable doctors expertise unfamiliar. Therefore, in the later stages of the war, developing medical knowledge emerged through an increasing need for doctors. Evidently a noteable doctor, Harvey Williams Cushing, aspired to be a change for surgeons and first aid responders in the war. From 1905 on, Harvey Williams Cushing, advanced neurosurgery through a series of operations through his writings. Cushing led a pathway to a team of doctors who perpetually enhanced the performance of medical care today.