Grignard Reaction Lab Report Essay

527 Words2 Pages

Experiment 10
Grignard Reactions
Name: Lidia Santiana Palha
Student number: s3333523
Email-address: lidiapalha@gmail.com
Name of demonstrator: H.Helbert










Reaction Equation


Summary
In this experiment a Grignard reaction was carried out to give the desired reagents: benzyl magnesium chloride. This was achieved by reacting benzyl chloride with magnesium in ether. After the Grignard’s reagents were formed, it was reacted with benzaldehyde in ether to give 1,2-diphenylethanol. The main objective of this experiment was to synthesize 1,2-diphenylethanol via a Grignard reaction. The NMR proves that the right product was formed in this experiment.
Introduction
The Grignard reaction is also known as an organometallic chemical reaction. …show more content…

Now looking in Fig.1 it shows how nucleophilic the Grignard’s reagents are. The carbon because partially negatively charged and the Chlorine to be partially positively charged. Due to this the Second part: first step shows how the nucleophile attacks the partially positively charged carbonyl and the electrons move to the oxygen atom making it negatively charged. The second step is protonation and this proton comes from the acid. The negative oxygen attacks the proton to give an alcohol.
Experimental
Making benzylmagnesium chloride.
All glassware is dried under N2 to remove all the oxygen. In a 250-ml three necked flask equipped with a reflux condenser (and a N2 line) and a dropping funnel, magnesium turnings (2.7g) were placed. A small crystal iodine was heated with a heat gun and produced purple vapour (this was done to activate the Mg). 5ml of dry diethyl ether was added slowly. Then a solution of benzyl chloride (6.5g) and diethyl ether (25ml). After the completion of the reaction, it was heated under reflux for 30 mins.
Synthesis of …show more content…

It was added carefully. Then heated under reflux for 1 hour. After cooling to room temperature, the reaction was quenched by pouring the mixture into a beaker of ice and saturated ammonium chloride solution(20ml). The layers were separated and the aqueous layer was extracted with diethyl ether (2 x 20ml). The combined organic layers were washed with water and saturated aqueous NaCl solution, dried on NasSO4. After filtration, the mixture was put on the rotavap and the product crystallized. An NMR was taken to determine if the right product was

Open Document