Prozac: Fluoxetine

1756 Words4 Pages

Prozac: Fluoxetine

Many people, both those who have experienced the illness

and families and friends that have helped loved ones cope

with it, are familiar with the far reaching effects of

depression. Depression is one of the most common medical

conditions in United States and around the world. At some

point in their lives one in four, approx 18 million,

Americans will experience some episode of depression. For

people struggling with depression there is help available.

Antidepressant medications and other treatments can often

make an astonishing difference in depressive symptoms within

a few weeks. With the right treatment eight out of ten people

improve. Before the 20th century, most people experiencing

depression went without diagnosis and treatment. Early, crude

forms of sedatives were given to people with severe

agitation, anxiety or psychotic depression. Like many other

aspects of science there has been an evolutionary growth of

the quality and range of availability of help for illnesses

like this. The involvement and evolution of anti-depressant

drugs is an important role in the fight against depression.

In the 1950s the fist generation of anti depressants was

discovered. It was not until the 1980s that a newer class of

antidepressants revolutionized the treatment of depression.

Selective serotonin reuptake inhibitors (SSRIs) were the

first of these medications to be available in the United

States. Fluoxetine (Prozac) was the first of its kind.

(Kramlinger, 2001)

Fluoxetine first appeared in scientific literature as

Lilly 110410 (the hydrochloride form), a selective serotonin

uptake inhibitor, in August 15, 1974 issue of, Life Sciences

(Wong,...

... middle of paper ...

...el A., (2001).Understanding Drug

Interactions. Proffesional Psychology: Research and Practice, Vol.32, No.5,

543-547: American Physiological Association Inc.

Sanchez, Connie, & Hyttel, John, (1999). Comparison of the

Effects of Antidepressants and Their Metabolites on Reuptake of Biogenic

Amines and on Receptor Bindings. Cellular and Molecular Neurobiology,

Vol.19, No.4.Denmark: Plenum Publishing Co.

Science Direct, (2003).Fluoxetine inhibits A-type Potassium

Currents in Primary Cultured Rat Hippocampal Neurons. Department of

Physiology, Medical Research Center, South Korea.

http://www.sciencedirect.com/science?_ob=ArticleURL.

Wong, David T., (1995).Prozac (Fluoxetine, Lilly 110140), The

First Selective Serotonin Uptake Inhibitor and Antidepressant Drug.

Life Sciences, Vol.57, No.5. Indianapolis, In: Elserver Science Ltd.

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