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Autoimmune diseases and pathology
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One of the many wonders of a perfectly functioning and healthy human body is its immune system, which may be considered as a powerful set of tools developed for resisting any sudden invasion of microorganisms or, any foreign particle as such. The striking feature of the immune system is self-tolerance, i.e. the body recognizes its own molecules and does not mount an immune response against them. Yet, there are some instances when this defence mechanism reverses and attacks the human body itself. This process, known as autoimmunity, is highly complex and is defined by loss of self-tolerance and the presence of autoantibodies or T-lymphocytes reactive with host antigens. Autoimmunity, although present in everyone to some extent, is the cause of a broad spectrum of human illnesses, called autoimmune diseases. Multiple factors are involved and the disease progression is determined by both genetic and environmental triggers. Pathogenesis of autoimmune diseases is governed by chronic excess reactivity of B and T cells against autoantigens, evidence of lymphocytic infiltrates in target organs and associated tissue damage.
Type 1 Diabetes mellitus (T1DM) is a multisystem disease with both biochemical and anatomical consequences. It is a chronic disease of carbohydrate, fat and protein metabolism, caused by the progressive autoimmune destruction of insulin-producing beta islet cells of the pancreas. This results in decreased production of insulin and consequently increased levels of blood glucose. The disease is hence, also, termed as Insulin-dependent Diabetes mellitus (IDDM) since the affected individuals are dependent on an external source of insulin, lifelong.
Insulin is produced in the pancreas by beta cells of the islets of Langerh...
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...f eTACs are loaded with our molecule of choice that we want to induce tolerance to, the autoreactive T-cells can be arrested. Such a strategy could help selectively shut down unwanted immune responses as occurs in autoimmunity.
Autoimmunity might be both the cause and consequence of beta-cell dysfunction. The identification of more autoantigens in the course of studies would be the focus point of treatment of autoimmunity. They can be exploited in much more diverse clinical attempts: such as tools to understand pathogenesis, to form the basis of biomarkers, and most importantly, to treat and prevent autoimmunity. It would also be imperative to carefully monitor the efficacy of autoantigen-dependent treatment procedures in future endeavours. Novel advances in this field of study are ever essential to further widen our horizon and contribute to this motif of research.
La autora Alfonsina Storni se presenta con su feminismo indirecto en su ensayo titulado “Autodemolición;” no escribe sus opiniones directamente, los describe sarcásticos, con ironía, y lo opuesto a la realidad. Storni era muy inteligente y sabia mostrar una visión feminista. Esto se ve muchísimo en carta de Sor Juana en la “Carta a Sor Filotea.”
The immune system is made up of a network of cells, tissues, and organs that work together to protect the body, and it defends the body from “foreign invaders.” Immunity can be divided in two three different defenses, and these are defined as first, second and third lines of defense. The first line of defense for the immune system is the primary defense against pathogens entering the body from the surface in order to prevent the start of disease and infection. Some examples of the first line of defense is the skin, protecting the external boundaries of the body, and the mucous membranes, protecting the internal boundaries of the body. Although the skin and mucous membranes work on the internal and external boundaries, they both release chemicals
Type 1 diabetes develops when the beta-cells are killed off by the immune system. This is because an inflammation is caused which the immune system fights off, ultimately destroying all/majority of beta cells. The role of the beta cells is to produce insulin within the pancreas. The beta cells are signalled when to release insulin’s to certain parts of the body. A person with type 1 diabetes is likely to have lost 70-80%1 of their beta-cells mass which is why they must manually inject insulin into themselves to maintain a healthy blood glucose level. When the blood glucose level falls (hypoglycaemia) you begin to lose energy.
According WebMD 2014. Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes. Type 1 diabetes mellitus, type 2 diabetes mellitus and gestational diabetes. It is a hormonal disorder of the pancreas either decrease in insulin level also known as hypoinsulinism or increase in insulin level also known as hyperinsulinism. Lowered amounts, insufficient of, or ineffective use of insulin leads to the disorder of diabetes mellitus. It is common chronic disease requiring lifelong behavioral and lifestyle changes. According to Peakman (2012). The development of type 1 diabetes mellitus is a genetic and an autoimmune process that results in destruction of the beta cells of the pancreas, leading to absolute insulin deficiency. There is usually a pre-diabetic phase where autoimmunity has already developed but with no clinically apparent insulin dependency. Insulin autoantibodies can be detected in genetically predisposed individuals as early as 6-12 months of age. In persons genetically susceptible to type 1 diabetes, a triggering event, possibly a viral infection the leads to production of autoantibodies that kill the beta cells and results in decline and a lack of insulin secretion. According to Wherrett. It is caused by impaired insulin secretion and insulin resistance and has a gradual onset. Those with type 2 diabetes may eventually need insulin treatment. Gestational diabetes mellitus is glucose intolerance during pregnancy in a woman not previously diagnosed with diabetes, this may occur if placental hormones counteract insulin, causing insulin intolerance. Complications in diabetes mellitus includes: Hypoglycemia it is ca...
Type 1 Diabetes Mellitus is also referred to as insulin-dependent as the secretion of the hormone insulin by the pancreas is reduced to minor levels due to the destruction of the pancreatic beta cells by immune system of the body. Therefore, Type 1 Diabetes is an autoimmune condition due to the fact that the body is harming the pancreas with antibodies so beta cells cannot make any insulin for bloodstream to take in glucose. The fact that the cells in the body cannot take in glucose means that it builds up in the blood and hyperglycaemia occurs. This abnormally high level of blood glucose is able to harm the nervous system, tiny blood vessels in the kidneys, heart and the eyes. Type 1 Diabetes is fatal when left untreated as it then causes heart disease, kidney disease, damage to the nerves, stroke and
1. Type 1 diabetes is a result from the body’s failure to produce insulin, which requires the individual to inject insulin in other ways (RCT).
...h factor VIII replacement therapy is best for them. Inhibitors are proteins called antibodies that are made by our immune system to defend us from harmful disease. When our immune system identifies a foreign substance, it makes antibodies that will specifically recognize that substance and destroy it.
Rheumatoid arthritis is a chronic inflammatory and an autoimmune disease that occurs when the immune system mistakenly attacks the body’s tissue (Rheumatoid arthritis, 2017). This disease affects the entire body, which is called a systemic (means entire body) disease. Arthritis is derived from the word part arthr-, which means “joint,” and -itis, which means “inflammation,” so altogether it means “inflammation of the joints.” It creates inflammation that causes the tissue that lines the inside of joints (synovium) to thicken. About 1.5 million people in the U.S. are affected. It affects all races, but it affects three times as many women than men (What is Rheumatoid Arthritis, n.d.). Overtime, rheumatoid arthritis causes painful swelling that can potentially result in bone erosion or joint deformity, which leads up to physical disabilities. RA can affect more than just your joints, but can spread to body systems, skin, eyes, lungs, heart, blood vessels, e.t.c (Rheumatoid arthritis, 2017).
“Immune Response: MedlinePlus Medical Encyclopedia.” National Library of Medicine - National Institutes of Health. Web. 18 Dec. 2011. .
Rheumatoid Arthritis is when the joints are chronically inflamed, which happens because it is an autoimmune disease which means that the immune system attacks the body tissues. Although Rheumatoid Arthritis mainly affects the joints, it can also affect other organs.
The immune system has the important job of protecting the body from foreign invaders. It is made up of a network of cells (including white blood cells), tissue and organs. The foreign invaders the immune system fight include viruses, bacteria, microbes and pathogens. In order to stop these foreign invaders, there is a process known as immune response that attacks in three different lines of defence. Without this immune response, the body would be constantly under invasion by pathogens trying to attack and induce illness.
The list of IB traits involve terms that a successful student should learn to adapt throughout their school years. Traits such as caring, risk-taker, open-minded, and balanced relate more to one’s personal life than traits like knowledgeable, thinker, reflective, principled, inquirer, and communicator which are more focused on the academic portion of one’s life. Although not everyone will begin the program with all these traits in their pocket, all students should grow and adapt towards new possibilities and a new personality than originally.
We are amazing human beings. Our bodies have been carefully constructed to protect ourselves from injury and harm. The protection of our body begins with the brilliant intervention of one small cell. According to Huether and McCance (2012), adaptive immunity is considered the third line of defense within our bodies. Adaptive immunity is summoned after the frontline or “external barriers” are compromised (Huether & McCance, 2012, p. 142). The process of inflammation arrives at the scene of invasion; next adaptive immunity is organized. Adaptive responses help our bodies fight disease at the scene. Additionally, adaptive responses maintain a unique memory to protect the body from future invasions. This paper will explore examples of the specific pathophysiology and associated alterations caused by adaptive responses.
One of the most common mysteries in the world is the development of autoimmune diseases. An autoimmune disease is when the immune system, which usually keeps your body healthy thinks that your healthy cells are antigens and attacks them. This is irony right? It is against properties of evolution for an immune system to attack itself causing sickness and possibly death if untreated. There are about 80 different types of autoimmune diseases, which usually have periods of little to no symptoms and worsening symptoms. What particularly creates confusion in the world is the autoimmune disease, inflammatory bowel disease, which affects almost about five million people worldwide.
... the case of autoimmunity, allergies, rheumatoid arthritis are but a few that the immune system failed to operate. When the immune system doesn’t work then modern medicine has to step in to help our body’s heel.