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Lymphatic System and Immunity Review
The Immune System: Innate and Adaptive Body Defenses
Lymphatic System and Immunity Review
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Adaptive Response We are amazing human beings. Our bodies have been carefully constructed to protect ourselves from injury and harm. The protection of our body begins with the brilliant intervention of one small cell. According to Huether and McCance (2012), adaptive immunity is considered the third line of defense within our bodies. Adaptive immunity is summoned after the frontline or “external barriers” are compromised (Huether & McCance, 2012, p. 142). The process of inflammation arrives at the scene of invasion; next adaptive immunity is organized. Adaptive responses help our bodies fight disease at the scene. Additionally, adaptive responses maintain a unique memory to protect the body from future invasions. This paper will explore examples of the specific pathophysiology and associated alterations caused by adaptive responses. Scenario 1: Tonsillitis Jennifer presents with the clinical signs and symptoms of tonsillitis. The clinical presentation of swollen tonsils, pain while swallowing, presence of exudates, associated temperature for three days, positive palpable anterior cervical nodes, and sore throat lead the clinician to believe Jennifer has tonsillitis. Tonsils are considered lymph tissue. The tonsils react to a microorganism that has come in contact via air droplet with the mouth, nose, or eyes. The resulting cytokine induced inflammation occurs in order to protect the body from infectious invasion. When this occurs inflammation mediators are activated and will lead to fever. Many lymphocytes and antigens get activated and start to fight the illness. The lymph nodes are enlarged because they are working harder to filter and clean the lymph fluid. Jennifer’s adaptive responses include inflammation, f... ... middle of paper ... ... her physical and emotional conditions. Her demands for energy are higher. Her body can compensate for the extra pressure she is experiencing. The added tension has led to decreased appetite and sleeplessness. Summary There are several types of adaptive responses in our body. Many of these pathways are intended to protect our body from illness, harm, or injury. It is important to understand the processes that occur at the cellular level in order to develop a treatment plan. Many of the adaptive pathways that are activated need to be either assisted with added protection or suppressed. According to Henry (2013), clinicians will guide interventions based on the knowledge of the body’s responses to harmful agents. Decisions will need to be determined by using the detail of the specific underlying pathophysiology of the clinical presentation and diagnosis.
The immunologic events that are happening at the local level during Carlton's acute inflammatory response would be:
(3) The stress from her work is another external factor that may have brought upon the irritability and feeling of not wanting to return to work. According to Thompson, Mata, Jaeggi, Buschkuehl, Jonides & Gotlib’s study they state “several factors may contribute to the high levels of instability of negative affect in depressed individuals… that depression status continued to be associated with instability of negative affect even after taking into account average levels of negative affect.”(3) This simply means that a personality variable such as anger, contempt, disgust, guilt, fear or nervousness can cause suicidal tendencies. Again, they, “… expect that group differences in emotional instability will be fully explained by the frequency or intensity of experienced significant events,”(3) which in Gracie’s case was her Ovarian surgery. Since menopause has previously been reported to cause psychological symptoms, this ovarian failure must be the first suspect. The patient had no pre-existing psychiatric illness preoperatively, but again given a more thorough exam we can provide her with a better clinical
The immune system is made up of a network of cells, tissues, and organs that work together to protect the body, and it defends the body from “foreign invaders.” Immunity can be divided in two three different defenses, and these are defined as first, second and third lines of defense. The first line of defense for the immune system is the primary defense against pathogens entering the body from the surface in order to prevent the start of disease and infection. Some examples of the first line of defense is the skin, protecting the external boundaries of the body, and the mucous membranes, protecting the internal boundaries of the body. Although the skin and mucous membranes work on the internal and external boundaries, they both release chemicals
Pharmaceuticals have examined and found to ”work by changing the biological functions of the target cells in the body through chemical agents“ (Doweiko, 2015, p. 16). ”Many people in the past have thought that drugs that
Kellermann, A., & Peleg, K. (2013, May 29). The New England journal of medicine. Retrieved from http://www.nejm.org/doi/full/10.1056/NEJMp1305304
“Immune Response: MedlinePlus Medical Encyclopedia.” National Library of Medicine - National Institutes of Health. Web. 18 Dec. 2011. .
The human immune system is an amazing system that is constantly on the alert protecting us from
Engel, G. L. (1977). The need for a new medical model: a challenge for biomedicine. Science, 196(4286), 129–136.
Seattle Education Project. (2013, November). STEP: The Immune System - An Overview, [Online]. Available: http://www.thebody.com/step/immune.html [11/12/14].
Stress does not directly causes infections or ill-health to a person. Instead, the products produced in the process of stress interfere with the usual operations of the immune system. Numerous studies have proved that stress has an immunosuppressive effect, which means the functions of the immune system is reduced when an individual is experience stress (Gross et al., 2008). Corticosteroids are initially produced during the alarm stage of the General Adaptation Syndrome (GAS), they do not usually cause any harm to the immune system. However, if the presence of corticosteroids is prolonged in the blood due to chronic stress, they can interfere with the production of the antibodies leaving the body vulnerable to harmful virus and bacteria (Gross et al., 2008). As described in the G.A.S model by Selye, individuals might experience drastic changes in their body such as high blood pressures and heart rates in order to cope during the stressful situations. If these changes are prolonged, this could lead to permanent damage to the body (Bailey et al, 2008).
The inflammatory response is a nonspecific response to cellular injury and bacterial invasion. Inflammation is the primary defense in early gingivitis. Biofilm can initiate an inflammatory response if it is left undisturbed for as little as seventy two hours. Redness and swelling are two of the cardinal signs of inflammation and can be observed clinically in gingivitis. Histamine is released by mast cells and responsible for the redness and swelling of tissues. Histamine causes both an increase in vascularity and permeability of blood vessels at the site of injury. Swelling may occur in response to the accumulation of fluid at a specific site. The inflammatory response includes cellular components of the immune system polymorphonuclear leukocytes and macrophages. Polymorphonuclear leukocytes are crucial to the cellular immune response. Polyporphonuclear leukocytes are the first cells that arrive at an inflammatory site. Polymorphonuclear leukocytes arrive at the site via chemotaxis, and begin to phagocytize bacteria. As the disease continues and the inflammatory reaction is not strong enough to subside the bacterial infection the immune response is further
Additionally, Isabella appears to be particularly stressed, as she appears to have a lack of support.
IN CONCLUSION, we can say that stress produces hormones (particularly glucocorticoids) which have a negative impact on the immune system when our bodies are exposed to them for a long period of time. However, when our immune system is exposed to particular stressors for a shorter period of time it may actually have a positive effect on our immune system and actually give it a “boost”. Stress in general has a major effect on our cytokines, natural killer cells and our T-lymphocytes, as they are most sensitive to the anti-inflammatory glucocorticoids. The Macrophage migratory inhibitory factor is one of the main reasons why our immune systems become hypersensitive to any allergens, when our bodies produce glucocorticoids. Stress therefore does have quite a large effect on our immune system and our body’s ability to fight disease.
DeVeale, B., Brummel, T., & Seroude, L. (2004). Immunity and aging: the enemy within?. Aging Cell, 3(4), 195-208.
more energetic, and in need of less food and sleep. When in this state of