Inflammation, Tissue Repair, and Wound Healing Case Study Carlton, a 6-year-old boy, was playing on a sandy beach with his mother. He began to run along the shoreline when he stepped on the sharp edge of a shell, giving himself a deep cut on his foot. His mother washed his foot in the lake and put on his running shoe to take him home. One day later, Carlton’s foot looked worse. The gash was red and painful. The foot was warm to touch and appeared swollen. Carlton’s mom put some gauze over the wound and prepared to take him to the local community health clinic. What is the physiologic mechanism causing the wound to become red, hot, swollen, and painful?How is this different than the inflammatory response that might occur in an internal organ? Carlton suffered an acute tissue injury on his foot after stepping on a sharp edge shell, which disrupted the layers of the skin. Immediately after an injury occurs, an inflammatory response begins, which serves to control and eliminate altered tissue/cells, microorganism, and antigens. This takes place in two phases. 1) The vascular phase, in which small vessels(arterioles, venules) at the site of injury undergo changes. Beginning, with …show more content…
The immunologic events that are happening at the local level during Carlton's acute inflammatory response would be: Margination and adhesion to the endothelium, in which accumulation of leukocytes occurs along the endothelial wall for adhesion. Afterward, these adhesions cause the separation of endothelial cells, allowing the leukocytes to extend and Transmigrate through the vessel walls. Followed by the response of chemical mediators(chemotaxis) that influence cell migration via an energy directed process which triggers the activation of Phagocytosis, in which monocytes, neutrophils, and tissue macrophages are activated to engulf and degrade cellular debris and
Inflammation: the response to injured tissue that stops bleeding and causes swelling and warmth as the tissue prepares to repair itself
“Immune Response: MedlinePlus Medical Encyclopedia.” National Library of Medicine - National Institutes of Health. Web. 18 Dec. 2011. .
There are many causes of accidental death in the United States, one of the most commonly seen are burn injuries. Burn injuries can effect a victim both internally (lungs) and externally (skin), they are so serious that many major hospitals have a burn unit area solely for the treatment of burn victims. In this research paper we will discuss the important issues dealing with the injuries of a burn victim such as the etiology, epidemiology, pathophysiology, complications and treatment.
Besides regulating hemostasis, endothelial cells also possess important functions like permeability, regulation of vascular tone, immunity, leukocyte trafficking, inflammation and angiogenesis among others.[1][2][3].
Wounds is a broad term that includes many other types. It is very important to know the proper and scientific method to care for wounds as well as knowing the types of them. Moreover, nurses must familiar with each type of wound, risk factors, prevention, and treatment. However, wounds may have a different range in skin breaks such as trauma, injury, cut, incision, and laceration. Skin prevention is the first step of preventing any break to occur in the skin. The various types of wounds, method of treatment and healing are mainly depending on their conditions. This assignment will include chronic wounds, which are diabetic ulcer, venous ulcer, and pressure ulcers.
Fig1. This is a picture of a leg with full blown necrotizing fasciitis, just prior to surgery. Note the discoloration. The skin feels crepitant and the area is extremely tender. A larger picture with detail is available by clicking this thumbnail print.
Due to the fact that people with chronic wounds are generally seen on a weekly basis in a clinic, the
Some cells cause inflammation of the tissue, which raises the temperature of the injured area and is adaptive because it prevents pathogens from entering and spreading into the host. The area of injured tissue also remains very sensitive to pain in order to avoid any type of stimuli
There are three main categories of burns, which are named for the depth of tissue affected by the burn. The first, and most common, type of burn is known as a superficial burn. This type of burn was formerly known as a first degree burn and it only effects the outermost layer of skin which is called the epidermis. Superficial burns are the least harmful and they usually heal in a week or less. The burn area is usually dry, red, and painful with no blisters present (“Classification,” 2013). The most common example of a superficial burn is a mild sunburn.
...-1 (PAI-1) from the endothelial cells and monocytes, activating the extrinsic coagulation pathway. This also leads to activation of factor X and fibrin production.
The inflammatory response is a nonspecific response to cellular injury and bacterial invasion. Inflammation is the primary defense in early gingivitis. Biofilm can initiate an inflammatory response if it is left undisturbed for as little as seventy two hours. Redness and swelling are two of the cardinal signs of inflammation and can be observed clinically in gingivitis. Histamine is released by mast cells and responsible for the redness and swelling of tissues. Histamine causes both an increase in vascularity and permeability of blood vessels at the site of injury. Swelling may occur in response to the accumulation of fluid at a specific site. The inflammatory response includes cellular components of the immune system polymorphonuclear leukocytes and macrophages. Polymorphonuclear leukocytes are crucial to the cellular immune response. Polyporphonuclear leukocytes are the first cells that arrive at an inflammatory site. Polymorphonuclear leukocytes arrive at the site via chemotaxis, and begin to phagocytize bacteria. As the disease continues and the inflammatory reaction is not strong enough to subside the bacterial infection the immune response is further
A wound is an injury to living tissue caused by a cut, blow, or other impact, typically one in which the skin is cut or broken. The skin is the body’s largest organ, making up 15% of the human body. It is responsible for temperature and protection of the body from various external influences. Wound healing is the normal body response to injury, either surgical or traumatic, causing disruption of the integrity of tissues. Surgical wounds are classified according to their degree of microbiology (2014 Advanced Tissues).
When a wound is determined as non-healable, as described by Sibbald et al (1), it should not be treated with a moist treatment and should be kept dry in order to reduce the risk of infection that would compromise the limb. It is also important to consider the patient 's preferences and try to control his pain, his discomfort in activities of daily living and the odour that their wound may produce. In this case, special attention must be given to infection prevention and control. Some charcoal dressing would be interesting in the care of our non-healable wounds at St. Mary 's Hospital.
The white blood cells destroy any unfamiliar pathogens in the bloodstream and can cause inflammation. Therefore, the inflammation causes a surplus of white blood cells to clot the wound for healing.
Loss of the protective sensation increases the risk of foot ulceration. Skin damage following any minor trauma will lead to foot infection and abscess formation that eventually leads to ulceration.