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Endocarditis case study
Endocarditis case study
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Endocarditis (IE) is an infectious disease affects the inner parts of the heart especially the heart valves. In spite of fungi can rarely cause IE, bacteria are considered the main cause of IE particularly Staphylococci, Streptococci, and Enterococci. IE is associated with fever, night sweats, weight and appetite loss, and cardiac and pulmonary illness. The diagnostic method is not complicated but it can not be obtained immediately with possibility of presence of negative results which effect on the final decision of the clinical team and the rate of recovering. Antimicrobial and surgery are the optimal treatment methods for IE. The difficulties of the treatment are being in IE cases with specific complications. Despite the use of antibiotic prophylaxis is recommended, its benefits are still uncertain.
Introduction Endocarditis
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Infectious agents are considered the most reason that causes IE by sticking to interior parts of the heart such as cardiac valves to damage the valves and make vegetations which including of bacteria, inflammatory mediators, and cells 9. Despite there are several microorganisms can cause IE, Staphylococcus aureus (S. aureus ) is the most common isolated pathogen in IE 8. The difficulties connected with IE become greater than the past. IE's patients are older and sicker, virulent staphylococci became the common reason of IE instead of penicillin-sensitive streptococci in developed countries, drug resistance is growing which is the most subject that worries scientists in treating IE. Additionally, quick and accurate diagnosis and decision from specialists are required, and providing high-level care is not simple for patients with IE
Addie acquired Stenotrophomonas bacterial infection in the hospital. She acquired it from the tubes of the lung bypass machine ECMO which doctors used to try and support her respiration after her
The patient is a 30 year old male with an active bacterial infection on his right leg attacking his Integumentary system. The patient is from Tanzania, Africa but came back to work in a factory that produces plastic. If he has Cellulitis, it can get bad enough to travel to other organs like the Liver and Kidney and cause failure. If this happens, Edema can form, usually on one half of the body; this is the Urinary system being attacked. The main system being attacked is the Lymphatic system because Cellulitis attacks the lymphatic draining system. For Cellulitis to travel to organs, it had to go through the blood, so the cardiovascular system is also in effect.
Cardiomyopathy, by definition, means the weakening of the heart muscle. The heart is operated by a striated muscle that relies on the autonomic nervous system to function. Cardiomyopathy is diagnosed in four different ways based on what caused the illness and exactly what part of the heart is weakened. The four main types of cardiomyopathy are dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and arrhythmogenic right ventricular dysplasia. One other category of cardiomyopathy that is diagnosed is “unclassified cardiomyopathy.” Unclassified cardiomyopathy is the weakening of the heart that does not fit into the main four categories.
Dental practitioners take action to minimize the risk of a disease from certain procedures that may allow bacteria from the mouth to enter the bloodstream. Antibiotic premedication therapy is a prophylactic measure that prevents bacteria from being released into the blood stream. The bacteria can infect the heart lining, as well as the valves or blood vessels, causing them to become inflamed. Infective endocarditis (IE), the name for the inflammation, has the potential to be fatal or debilitating. The risk of developing IE can happen from a combi¬nation of high-risk patients and dental procedures. While this is not an issue for most patients, some do require protection. The American Heart Association recommends antibiotic premedication therapy before dental procedures. But only for those whose cardiac conditions as well as a few other conditions are associated with the highest risk of adverse outcome.3
These causes will change the heart significantly. The pathophysiology of heart failure is described differently as: (1) an oedematous disorder, by means of which the deviations in renal hemodynamics and excretory ability lead to salt and water holding; (2) a hemodynamic disorder, considered by peripheral vasoconstriction and decreased cardiac output; (3) a neurohormonal disorder, mainly by stimulation of the renin-angiotensin-aldosterone system and adrenergic nervous system; (4) an inflammatory syndrome, related with amplified local and circulation pro-inflammatory cytokines; (5) a myocardial disease, started with an damage to the heart trailed by pathological ventricular transformation. In heart failure, the heart sustains either a sudden or longstanding structural injury. When damage occurs, sequences of firstly compensatory but consequently maladaptive mechanisms follow (Henry & Abraham, ).
In conclusion, endothelial cells in atherosclerosis causes the increased expression of surface adhesion molecules which results in the increased amount of leukocytes attracted to the site and thus causing more inflammation than usual. In infective endocarditis, NBTE allows bacterial adhesion of the heart valves, mediated by ClfA and then FnbpA. These causes a range of reactions spanning of vegetative growth to inflammation.
(Nemours, 1995-2011) The two main bacteria precipitating Impetigo are staphylococcus aureus, the most common cause, and streptococcus pyogenes. If left untreated, streptococcus pyogenes can also cause post-streptococcal glumerulonephritis, or a disease that causes inflammation of the kidney to occur following a strep throat infection. Although this is rare, standard precautions must still be taken to prevent these repercussions. Staphylococcus aureus and streptococcus pyogenes are the main causes of impetigo, but they are not the only.
Acute pericarditis can vary with the regularity of auscultation also known as the classic Pericardial rub. The pericardial rub is when the patient is auscultated covering the left lower sternal frame and corresponds to the movement of the heart against the pericardial sac. When the patient breathes out and leaning forward It has a creaking sound (Tingle, Molina & Calvert, 2007). We can assume that this 57 year old patient was not showing creaking sounds within his chest. This is present in pericarditis patients, on the other hand with AMI it presents as absent. The symptoms the patient presents are also symptoms of AMI such as he was complaining of numbness in the left arm and chest pain (Zuzelo, 2002). Also the reason why this patient must be suffering from AMI is because he has ST- elevation myocardial infarction (STEMI) which is results from thrombotic blockage of epicardial coronary artery. Infarction of a significant part of the left ventricle can result in evidence of low cardiac output such as, sinus tachycardia which is exactly what the patient was showing on the monitor (Ardehali, Perez & Wang, 2011).
A., Gewitz, M., Lockhart, P. B., Baddour, L. M., Levison, M., . . . The Council on Scientific Affairs of the American Dental Association has approved the guideline as it relates to dentistry. In addition, this guideline has been endorsed by the American Academy of Pediatrics, Infectious Diseases Society of America (2007). Prevention of infective endocarditis: Guidelines from the American Heart Association: A guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group". Circulation, 116(15), 1736-1754.
The initial cause of all further problems is the infection. This can occur anywhere in the body. The most common sites of infection that can lead to sepsis include: urinary tract, skin, abdominal, and respiratory. These infections can occur at any time, in any population; however, there are some groups of people who are at a higher risk. These include individuals who have been diagnosed with: diabetes mellitus, renal failure, heart failure, and chronic obstructive pulmonary disease (Leon, Hoyos, Barrera, De La Rosa, Dennis, Duenas, Granados, Londono, Rodriguez, Molina, Ortiz, Jaimes, 2013). The infection is the first step in patients who go into septic shock. Performing cultures and treating this infection e...
bacteria can spread to the heart and arteries causing life threatening problems. It is obvious that
(Slide 2) What is Cardiomyopathy? If we break down the word we can see “Cardio” which means of the heart, “myo” which means muscle, and “pathy” which means disease, therefore cardiomyopathies are diseases of the heart muscle. (Slide 3) There are 3 main types of cardiomyopathies; hypertrophic, dilated, and restrictive. I will only be discussing dilated cardiomyopathy, which is characterized by the enlargement of the hearts chambers with impaired systolic function. It is estimated that as many as 1 of 500 adults may have this condition. Dilated cardiomyopathy is more common in blacks than in whites and in males than in females. It is the most common form of cardiomyopathy in children and it can occur at any age (CDC).
In contrast to the host response, the transcriptional response of S. aureus varied significantly between control and diabetic mice. We observed a significant increase in gene induction associated with translation while decreases in amino acid transport as well as genes of unknown function. This does contrast slightly to a study that examined S. aureus expression in diabetic rats in an endocarditis model, whereby amino acid transport genes were upregulated (66), this just may be reflected of the significantly different infection models. Many of the upregulated genes of S. aureus under diabetic conditions were associated with heat shock and cellular stress, an interesting observation given our host expression data, suggestive the infection site
Hospital acquired infections are one of the most common complications of care in the hospital setting. Hospital acquired infections are infections that patients acquired during the stay in the hospital. These infections can cause an increase number of days the patients stay in the hospital. Hospital acquired infections makes the patients worse or even causes death. “In the USA alone, hospital acquired infections cause about 1.7 million infections and 99,000 deaths per year”(secondary).
The patient has high temperature-sign of fever, a very fast pulse rate (tachycardia), and chest wheezing when listened to using a stethoscope (Harries, Maher, & Graham, 2004, p.