Cardiorespiidity And Morbidity

673 Words2 Pages

The world is changing with the advancement of technology. People in our society, including teenagers, adults, and elders addicted to computers, television, cell phones, videogames, and cars. This addiction is making them sedentary. Going back in history, the human body is made for hunting, farming, and household work but the advancement of technology is making us sedentary. The sedentary lifestyle is leading increase in chronic health conditions and higher all-cause mortality. Human body is reacting to this change in nature, by being less immune to numerous chronic health conditions. Over the past several decades, numerous studies including observational and experimental, have examined and shown that physical activity significantly decreases morbidity and mortality. Moderate to vigorous physical activity helps in improving the cardiorespiratory fitness of a person which in turn helps in decreasing the risk of chronic health conditions including, cardiovascular disease, hypertension, type-2 diabetes, and cancer. Also numerous studies have shown that, physical activity or cardiorespiratory fitness reduces morbidity and mortality independent of body weight. India, which is known as the capital of diabetes includes a large cohort of people with diabetes, having a normal BMI. Low physical activity or cardiorespiratory fitness could be the major reason for the cause diabetes in this cohort. Physical activity prevent weight gain or help in controlling weight by increasing the energy expenditure. Although most studies have shown that physical activity prevent morbidity and mortality independent of weight, the range of benefits vary for among various groups stratified according to age, sex, race and BMI. Also, different dose of physical ... ... middle of paper ... ...en and elastin. Studies have shown that exercise prevents changes in collagen and elastin which leads to stiffness. Exercise also prevent accumulation of advanced glycation end-product which increases with age and is known to cause stiffness. There is strong evidence that exercise result in collateral growths of artery in the cardiac muscles. The mechanism behind this is attributed to stem cells similar to angiogenesis. Population with atherosclerosis or other similar damages to the vessels can benefit from exercise as it lead to increase in collateral growths. Last but not the least mechanism, which helps in prevention and cure of CVD, are microRNAs. Different microRNAs have different mechanism and consequences. MicroRNAs 21 leads to increase in fibrosis. MicroRNAs 29 helps in promoting angiogenesis. MicroRNAs 126 is involved in improving ventricular compliance.

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