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Medical advancement of penicillin essay
Antibiotic resistance
Medical advancement of penicillin essay
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Environmental pressures can change a species over time, based on Darwin’s theory of natural selection and “survival of the fittest”. If a pressure affects a large number of the same species, two outcomes are possible. The species will either become extinct, or more commonly, a small percentage of the original population will outlast the pressure (generally due to a mutation in its genes, making it resistant to a specific occurrence). The remainder of the species will reproduce the population, passing on their mutation to some of their offspring, until all organisms carry that mutation (often after several generations.
The above occurrence has lead to some bacteria becoming resistant to some forms of antibiotics (aka antibiotic resistant bacteria).
Antibiotics were first discovered by Professor Alexander Fleming in 1928 by accident when cleaning up his laboratory. This coincidental discovery lead to Fleming and many other scientists changing society and medicine and the way people looked at what we now see as simple to treat. Prior to the discovery, surgery was almost impossible to perform due to the risk of infection, and nothing to counteract the bacteria. With the introduction of antibiotics, infections now being treated were before considered to be dangerous and even deadly. Antibiotics have saved millions of lives in the approximate 100 years since it has been discovered.
However, as antibiotics have been overused, underused and misused in treating bacteria as well as viruses (which antibiotics do not have an effect on), bacteria have begun to fight back and some have altered their DNA to become harder to treat with antibiotics. When this happens, bacteria are no longer sensitive to this medication that would have on...
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...sk. Available: http://www.mayoclinic.org/healthy-living/consumer-health/in-depth/antibiotics/art-20045720?pg=1 . Last accessed 27/04/14.
Mayo Clinics are all over the United States and the staff aim to contribute to health and well being. Mayo Clinic is an educational facility, as well as providing health care and researching important medical issues and trying to aid in finding a cure for many threatening things. It provides information similar to those previously mentioned, plus more and is aimed at the preventions individuals can carry out themselves.
The above sources contain very similar information, leading me to believe that the information is reliable and valid on all sites, based on what health professionals know of these advanced bacteria so far. They are also well used sites with good reputations and are mostly government or medical organisations sites.
Penicillin, derived from the mold Penicillium, is the first antibiotic to successfully treat bacterial infections on humans. It was accidentally discovered by scientist, Alexander Fleming. While Fleming was growing Staphylococcus, a serious and often deadly infection, in a dish, he noticed the bacteria had stopped growing after a mold found its way
In the last decade, the number of prescriptions for antibiotics has increases. Even though, antibiotics are helpful, an excess amount of antibiotics can be dangerous. Quite often antibiotics are wrongly prescribed to cure viruses when they are meant to target bacteria. Antibiotics are a type of medicine that is prone to kill microorganisms, or bacteria. By examining the PBS documentary Hunting the Nightmare Bacteria and the article “U.S. government taps GlaxoSmithKline for New Antibiotics” by Ben Hirschler as well as a few other articles can help depict the problem that is of doctors prescribing antibiotics wrongly or excessively, which can led to becoming harmful to the body.
Resistance arises from mutations that are not under the control of humans, but the evolution of bacteria has been sped along by the overexposure of antibiotics to both people and animals. The number of antibiotic-resistant strains of bacteria in an area is closely related to the frequency that antibiotics that are prescribed (Todar, 2012). Patients often unnecessarily demand antibiotics to treat common colds or simple illnesses that are not caused by bacteria. Instead, these infections are caused by viruses which, unlike bacteria, are unaffected by antibiotics. Incorrect diagnosis can also lead patients to using unnecessary antibiotics, which can sometimes be even more dangerous than otherwise left untreated. Besides the fact that antibiotics kill off beneficial bacteria in the intestines, misuse of antibiotics provides an opportunity ...
Acquired antimicrobial resistance generally can be ascribed to one of five mechanisms. These are production of drug-inactivating enzymes, modification of an existing target, acquisition of a target by-pass system, reduced cell permeability and drug removal from the cell. (Sefton) Also a bacterium that was once prone to an antibiotic can gain resistance through alt...
Evolution in general, is a hard concept to grasp. There are multiple factors that effect the outcome a species, for example: genetics, nurture, nature, and the environment all play an important role. It was once said that species do not survive due to the fact that they are the strongest or the most intelligent, but because that species is the most responsive to change.
Through millions of years of evolution, well-balanced habitats have co-evolved to provide for the wide variety of species and their needs. Trees have adapted to weeds, weeds have adapted to the predation from herbivores, and so on up the food chain. Similar scenarios are seen throughout the world. Through the process of natural selection, specific species or broad species families will go extinct. However, these occurrences have largely been due to the natural flow and evolution of time. It wasn’t until recently that dominant species, such as humans, have taken the course of nature into their own hands.
Long-term survival of a species depends on its ability to adapt to changing environmental conditions (Murphy, 1994). Genetic diversity within a species, which has taken 3.5 billion years to evolve, makes adaptations to these changing environments possible. Unfortunately, the rate of extinction of genetically diverse organisms is rapidly increasing, thus reducing this needed biodiversity, largely due to the human impacts of development and expansion. What was an average of one extinction per year before is now one extinction per hour and extinct species numbers are expected to reach approximately one million by the year 2000 (WWW site, Bio 65). As a result governmental and societal action must be taken immediately!
Throughout history disease has run rampant taking many lives with every passing day. Finding a cure or even just a tool in the battle has been the main focus of scientist throughout time. This focus is what brought us the discovery of antibiotics. Over the years antibiotics have been misused by patients, over prescribed by physicians and have led to resistant strains of bacteria.
Bacteria that is resistant to antibiotics is a major problem not only for the United States, but worldwide. According to the Centers for Disease Control and Prevention (2012) the cause is related to “widespread overuse, as well as inappropriate use, of antibiotics that is fueling antibiotic resistance”. According to World Health Organization (2013) resistance is a global concern for several reasons; it impedes the control of infectious diseases, increases healthcare costs, and the death rate for patients with resistant bacterial infections is twice of those with non-resistant bacterial infections.
This turn of events presents us with an alarming problem. Strains of bacteria that are resistant to all prescribed antibiotics are beginning to appear. As a result, diseases such as tuberculosis and penicillin-resistant gonorrhea are reemerging on a worldwide scale (1). Resistance first appears in a population of bacteria through conditions that favor its selection. When an antibiotic attacks a group of bacteria, cells that are highly susceptible to the medicine will die.
Alexander Fleming started the history of antibiotics in the 1920's with his discovery of penicillin.When penicillin was first discovered and used widely, it was touted as a wonder drug, and consequently was used as one.Though not necessarily harmful to the patient penicillin was used for much more infections than it was able to combat.Today the same practice is observed in the medical profession, however at this point it is due more to the detriment of an uneducated public.Studies have been carried out that show the huge over usage of antibiotics.In the seventies Soyka et al, concluded, "60% of physicians surveyed gave antibiotics for the treatment of the common cold."[3], and by common knowledge the common cold is a virus, something that cannot be treated by an antibiotic.Nyquist
of species due to a variety of causes. Included is out competition, depletion of resources
In many parts of the world, ecosystems’ temperatures begin to rise and fall to extreme levels making it very difficult for animals and plants to adapt in time to survive. Climate has never been stable here on Earth. Climate is an important environmental influence on ecosystems. Climate changes the impacts of climate change, and affects ecosystems in a variety of ways. For instance, warming could force species to migrate to higher latitudes or higher elevations where temperatures are more conducive to their survival. Similarly, as sea level rises, saltwater intrusion into a freshwater sys...
As the following report demonstrates, some species are adapting to climate changes while many others are not. In some cases, laboratory experiments have lead to the conclusion that certain species can or cannot adapt and evolve. This research is not sufficient to make definitive statements regarding what will happen to species if temperatures and sea levels continue to rise.
Exposure to antimicrobials fundamentally alters microbial ecosystems of humans, animals and the environment, which may lead to the development of antimicrobial resistance.