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Misuse and consequences of antibiotics essay
Discovery of penicillin
Alexander Fleming's words when he invented penicillin
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Antibiotics
Throughout history disease has run rampant taking many lives with every passing day. Finding a cure or even just a tool in the battle has been the main focus of scientist throughout time. This focus is what brought us the discovery of antibiotics. Over the years antibiotics have been misused by patients, over prescribed by physicians and have led to resistant strains of bacteria.
Resistant strains are no joke, for years my mother has been dealing with MRSA (methicillin-resistant staphylococcus aureus). My mother has had MRSA so bad that at one time she was covered in MRSA sores much like when a person breaks out in hives. Watching her suffer the way she has worries me as I am also a healthcare worker and know what these resistant strains are capable of. I know these strains exist because of a lack of proper patient education. Proper patient education is key to the use of antibiotics and prevention of resistance-bacteria strains.
A Brief History
To provide proper patient education there first needs to be an understanding of the history of antibiotics. “Alexander Fleming identified the mold Pecicilium notatum, which inhibited the growth in certain bacteria. Examples of these bacteria re Staphylococcus aureus, haemolytic streptococcus, pneumococci, and meneingococci. In 1929, he published his findings suggesting that penicillin could be used for treatment but he made no further progress.”(141-142)
Ernest Chain and Howard Florey with the knowledge of Flemings work were able to successfully purify an extract of penicillin for testing. The tested it in 1940 on mice, they concluded that those who were given the penicillin lived whereas the others did not. Later in 1945 all three men received the Nobel Prize for their contr...
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...ntibiotics are used for. Antibiotics are used to fight bacterial infection not viral. That means antibiotics don’t work on the common cold or flu. Some patients pressure their physician into prescribing antibiotics for those viral infections. “This pressure can include explicit requests, appeals to non-medical circumstances, accounts of previous consultations and self-diagnosis” (292)
Conclusion
“The World Health Organization projects that as drug effectiveness decreases and antibiotic resistance increases, public education becomes more and more crucial” (476) Antibiotics were discovered in 1940 and since have been abused and misused. Between bad practices and lack of proper education antibiotic resistance has been allowed to occur. The only way to combat bacterial infections is with strong patient education and following the correct schedule in taking antibiotics.
Nurses should take a leading role in reducing the impact of disease on patients and influence the expansion of evidence based infection prevention practice. Antimicrobial resistance prevention must remain a huge priority. In times of opposing priorities concerning patient safety, progress has been made in undertaking these bacteria’s and infections. The outlook of a near future without helpful antibiotics should not be dismissed, and all us in positions of influence should encourage and educate the conscientious use of antimicrobials seriously and do what we can to stop the situation from spreading.
Staphylococcus aureus is a bacteria that is abundant in many places. It can even be found in some of our bodies. These bacteria are harmless as long as none of them are Methicillin resistant Staphylococcus aureus (MRSA). Methicillin is the name of a family of antibiotics that includes penicillin. This MRSA is the deadly superbug that has developed resistant to antibiotics. Statistics show that MRSA contributes to more US deaths than does HIV. It has become a huge threat to every country as the outbreaks can be a surprising one. This threat is caused by the evolution of the bacteria. These superbugs have evolved a resistance of antibiotics which makes them extremely difficult to treat. One article states, “In the early 1940s, when penicillin was first used to treat bacterial infections, penicillin-resistant strains of S. aureus were unknown — but by the 1950s, they were common in hospitals. Methicillin was introduced in 1961 to treat these resistant strains, and within one year, doctors had encountered methicillin-resistant S. aureus. Today, we have strains of MRSA that simultaneously resist a laundry list of different antibiotics, including vancomycin — often considered our last line of antibacterial defense.” [1]
Carroll. Even with widespread controversy over antibiotic resistance, Carroll remained neutral with his writing, pointing out facts that fit both sides of the argument. One of the most important issues addressed in the article was the lack of education when it comes to the proper use of antibiotics. The health of the public would benefit greatly from education about viruses and bacterial infections. Carroll’s article is a good resource for the basis of the topic’s education. The article informs readers about the importance of antibiotics and the development of antibiotic resistance as well as future prevention and research for antibiotic
The common cold is one of the most prevalent illnesses worldwide. It is caused by a virus that inflames the membranes in the lining of the nose and throat, colds can be the result of more than 200 different viruses [10].The antibiotics don't work against any infections caused by viruses [11]. They are a powerful medicines that fight bacterial infections [12]. Antibiotics were first used to treat serious infections in the 1940s. Since then, antibiotics have saved millions of lives and transformed modern medicine. During the last 70 years, however, bacteria have shown the ability to become resistant to every antibiotic that has been developed [13].Taking unnecessary antibiotic can be dangerous to the health and can increase the risk of antibiotic resistance [14]. World Health Organization (WHO) define the Antimicrobial resistance (AMR) as the resistance of a microorganism to an antimicrobial agent to which it was originally sensitive. [3] Antibiotics were prescribed in 68% of acute respiratory tract visits and of those, 80% were unnecessary according to disease control center (CDC) guidelines. $1.1 billion is spent annually on unnecessary adult upper respiratory infection antibiotic prescriptions. When antibiotics fail to work, the consequences are longer-lasting illnesses, more doctor visits or extended hospital stays, and the need for more expensive and toxic medications. Some resistant infections can even cause death [2].The judicious prescription of antibiotics has become a central focus of professional and public health measures to combat the spread of resistant organisms. [15]
...lance and monitoring systems, inadequate systems to ensure quality and uninterrupted supply of medicines, inappropriate use of antibiotic medicines, poor infection prevention and control practices, insufficient diagnostic, prevention and therapeutic tools. WHO is guiding the response to antibiotic resistance through; fostering coordinated actions by all stakeholders; creating policy guidance, support for surveillance, technical assistance, knowledge generation and partnerships; fostering innovation, research and development. WHO calls on all key stakeholders, including policy-makers and planners, the public and patients, practitioners and prescribers, pharmacist and dispensers, and the pharmaceutical industry, to act and take responsibility for combating antibiotic resistance.
Antibiotics are used worldwide and although their uses have helped many people, it doesn't come without risk. The use of antibiotics treats people and animals alike to cure infection and are easily excusable through physicians. However in recent years, since antibiotics are used so universally, antibiotic- resistant strains have become a growing problem. This suggest that the bacteria is adapting to the antibiotics and through natural selection, the antibiotic- resistant bacteria have grown in numbers. The scientific community worries about future treatment of diseases if the bacteria continues to adapt. For example tuberculosis which hasn't been a problem in some time, has started to reoccur as a much harder to treat strain. Antibiotics are the go to method of treating infection but we need to be careful when we are using them.
Thesis: With the advent of antibiotics in 1929 Fleming said, "The time may come when penicillin can be bought by anyone in the shops.Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant."With the overuse of antibiotics today we have seen this very idea come to be.Over usage is caused most prevalently by a lack of education on the part of the patient.Thus stated, the way to overcome such a circumstance is to educate, not only the patient but also the physician.
The intended audience was National History Day judges, but may include those who are trying to learn the history of antibiotics. This is identifiable from other sources by being a compilation of historical data as well as primary facts. This contributed as a secondary source from which readers can understand how antibiotics were discovered, rather than how they influenced medicine.
The intervention of this study consisted of mailing antibiotic guides to providers along with an antibiotic prescribing profile that targeted infections such as urinary tract infections, lower respiratory tract, and skin infections, and infections of unknown origin. At the end of the study results revealed that non-adherent prescriptions decreased by 20.5% in the experimental group and 5.1% in the controlled group (Monette, et al., 2007). The result of this case showed that education follows with a current antibiotic guide and prescription profile was useful in decreasing the amount of non-adherent prescription of antibiotics in patients that reside in
Acknowledging that the effects of antimicrobial resistance can negatively impact all healthcare settings, proper management over the use of antibiotics is crucial to control the emergence and transmission of antimicrobial-resistant organisms. Requiring every hospital to adopt an antimicrobial stewardship program (ASP) can create an effective way to ensure the appropriate, optimal antibiotic prescribing. The Infectious Diseases Society of America (IDSA) defines the primary purpose of these programs are to enhance clinical outcomes while decreasing unintended consequences of antimicrobial use, including toxicity, the selection of pathogenic organisms, and the emergence of antibiotic resistance (File, Srinivasan, & Bartlett, 2014).
During the pre antibiotic era in the early 1900’s the leading causes of death were tuberculosis, enteritis, and multiple strains of streptococcus, all bacterial infections. Equally terrifying was that some of these simple infections were 80% fatal if contracted. However, a breakthrough happened when Alexander fleming discovered penicillin in 1928, even though it wasn’t mass produced until 1939. Thus, the antibiotic era emerged quickly reaching its golden age (1941-1962) where they had 14 novel classes. Most were very optimistic, saying infections have basically been wiped out in America, but some people had their doubts. Flemming even predicted bacteria will develop resistance, and resistance plasmids were discovered in the 1940s but it didn’t seem to matter. After the 1960’s no new classes were being made, only little changes to the 4 remaining classes. It wasn’t until 1999 when a new class was made, so were not very fast at making antibiotics. In summary, the future for antibiotics seemed bright and limitless. However, bacterial evolutionary adaptation always seems to get the better of us in the
Studies in Canada and the United States show that approximately half of all prescribed antibiotics to ambulatory patients are unnecessary. Even when the prescribed treatment is correct, the patients usually stop taking the medication right after the main symptoms disappear. This increases the risk of drug resisting diseases.
It also had to be produced in practical amounts or only a trivial amount of people would be able to receive this medicine. Howard Florey and Ernst Chain began the effort of devising a way of using penicillin in humans. Part of the reason this drug was needed was to reduce the bacterial infections in soldiers’ wounds from World War II. The nature of the medicine is to stop the growth of bacteria, so in the wound it would prevent any infection from spreading, sparing the life of the soldier. However, to be able to treat the vast number of injured soldiers, a better method of producing penicillin would have to be developed. This method was to pump air into deep vats containing corn steep liquor and adding other key ingredients, which produced penicillin faster and in larger amounts than with the surface-growth method. With a clear purpose for penicillin and a way to produce it in significant amounts completed, the medicine could then be used for treating the wounded soldiers and saving countless
At his Nobel Peace Prize speech in 1945, Alexander Fleming warned against the misuse of antibiotics and the fact that by doing this, one allows the bacteria to ‘become educated’ and therefore become resistant to the antibiotic. It is believed that the first cases of antibiotic resistance were shortly after this speech. (Fleming, 1945)
One of the most important breakthroughs in modern medicine and public health efforts is the discovery of Penicillin by Alexander Fleming in 1928. The effects of this discovery cannot be overstated; antibiotics have saved millions of lives and have significantly reduced morbidity and mortality in the global population (Fauci & Morens, 2012). The 1950s and 1970s saw the discovery of many new antibiotics classes, with no new classes of antibiotics discovered since the late 1980s (Aminov, 2010). While integral to the survival of many people, public health officials and the Centers for Disease Control have warned that the overuse and improper use of antibiotics by humans and industries can limit the effectiveness of antibiotics and create antibiotic resistant strains of diseases (Ventola, 2015).