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The danger that antibiotic resistance poses in today’s society
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Superbugs:
Overcoming the Resistance
Bio 1M03 PBL Project
March 11, 2014
This report has been edited and approved by all contributing group members before submission.
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
Resistance arises from mutations that are not under the control of humans, but the evolution of bacteria has been sped along by the overexposure of antibiotics to both people and animals. The number of antibiotic-resistant strains of bacteria in an area is closely related to the frequency that antibiotics that are prescribed (Todar, 2012). Patients often unnecessarily demand antibiotics to treat common colds or simple illnesses that are not caused by bacteria. Instead, these infections are caused by viruses which, unlike bacteria, are unaffected by antibiotics. Incorrect diagnosis can also lead patients to using unnecessary antibiotics, which can sometimes be even more dangerous than otherwise left untreated. Besides the fact that antibiotics kill off beneficial bacteria in the intestines, misuse of antibiotics provides an opportunity ...
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... antibiotic resistance has quickly become an increasing concern in recent times due to the growing use of antibiotics. To combat this problem, we propose that healthy intestinal floras be maintained after antibiotic resistance using fecal bacteriotherapy, and that processes of lateral gene transfer be disrupted before antibiotic resistance through the use of copper surfaces and after antibiotic resistance through synthesized CSPs. Continuing research in these solutions as well as implementing these strategies into mainstream medicine will certainly reduce the frequency of antibiotic resistance along with incidences of serious disease outbreaks in hospitals. With a better understanding of the causes of antibiotic resistance and the role that patients and doctors play in these causes, it is time to move forward and attempt to eradicate this problem once and for all.
In the last decade, the number of prescriptions for antibiotics has increases. Even though, antibiotics are helpful, an excess amount of antibiotics can be dangerous. Quite often antibiotics are wrongly prescribed to cure viruses when they are meant to target bacteria. Antibiotics are a type of medicine that is prone to kill microorganisms, or bacteria. By examining the PBS documentary Hunting the Nightmare Bacteria and the article “U.S. government taps GlaxoSmithKline for New Antibiotics” by Ben Hirschler as well as a few other articles can help depict the problem that is of doctors prescribing antibiotics wrongly or excessively, which can led to becoming harmful to the body.
Antibiotic-resistant bacteria are created when mutations in the pathogen's genetic code occurs, changing the protein in the bacteria that the antibiotics normally go after into a shape that the antibiotic can not recognize. The average bacteria divides every twenty minutes, so if a contaminated spot has one single bacteria in the morning, there could be trillions on that same spot at the end of the day. That means that when counting all the possibilities of mutations, the amount of mutated offspring that the bacteria might have formed during those replications could be as high as in the millions. Fortunately though, this does not happen so frequently that it is normally an issue. The amount of non-mutated bacteria vastly outnumbers the mutated ones and many of the mutations occurring in the bacteria usually have either a harmful effect, or not effect at all on its function. That means that the pathogen is still relatively less harmful than it c...
According to USA Today, U.S. doctors are prescribing enough antibiotics to give to 4 out of 5 Americans every year, an alarming pace that suggests they are being excruciatingly overused. In fact, Dr. Aunna Pourang from MD states, “to give you an idea of how high the pressure is to prescribe antibiotics, I didn’t get a job once because during the interview I told the lead physician that I only prescribe antibiotic prescriptions when they are warranted.” The development and widespread obsession of antibiotics, or drugs that kill bacteria and thereby reduce infection, has helped billions of people live longer, healthier lives. Unfortunately, the more we rely on and abuse antibiotics, the more bacteria develop resistance to them, which makes treating infections that much more challenging and leads to the growth of drug-resistant strains of bacteria. Research from the Center of Disease Control found that two million people in the United States become infected with antibiotic resistant bacteria, while 23,000 people die from such infections each year. Americans often aren’t informed on the power of the human body and rush to assumptions when perfection isn’t present. In a nutshell, the obsession of antibiotics is quite deadly and needs to be addressed before it’s too
Opiates are a class of drugs that are used for chronic pain. Opioids are substances that are used to relieve pain by binding opiate receptors throughout the body, and in the brain. These areas in the brain control pain and also emotions, producing a feeling of excitement or happiness. As the brain gets used to these feelings, and the body builds a tolerance to the opioids, there is a need for more opioids and then the possibility of addiction.
Hansen’s Disease also known as Leprosy dates back to at least 4000b.c. Evidence of the disease’s presents in ancient times was found on an Egyptian papyrus dating from around 1500bc. These earlier cultures believed it was a curse or punishment from the gods. During the middle ages, the afflicted wore special clothing and rang bells to alert the uninfected of their presence. The first known origin of this disease is Egypt from here Roman Crusaders contracted the disease and brought it back to Europe and from Europe to America.
Urinary tract Infections are commonly treated with sulfamethoxazole - trimethoprim and fluoroquinolones[7,10,12]. However, due to the frequency of antibiotic use, recurrent or chronic UTI and inappropriate use of antibiotics leads to the resistance of the common uropathogens specifically Enterobacteriaceae[13]. Other factors that lead to the acquisition resistance such as adaptation, transduction, conjugation, transformation, transposons, and efflux are also one of the reasons that render the commonly used antibiotic less effective. According to the WHO[14], antimicrobial resistance is of global concerns because of the following reasons: it hampers the control of infectious diseases, threatens a return to the pre-antibiotic era, increases costs of health care, jeopardizes health-care gains to society and threatens health security, damages trade and economy.
...lance and monitoring systems, inadequate systems to ensure quality and uninterrupted supply of medicines, inappropriate use of antibiotic medicines, poor infection prevention and control practices, insufficient diagnostic, prevention and therapeutic tools. WHO is guiding the response to antibiotic resistance through; fostering coordinated actions by all stakeholders; creating policy guidance, support for surveillance, technical assistance, knowledge generation and partnerships; fostering innovation, research and development. WHO calls on all key stakeholders, including policy-makers and planners, the public and patients, practitioners and prescribers, pharmacist and dispensers, and the pharmaceutical industry, to act and take responsibility for combating antibiotic resistance.
The controversy regarding the sub-therapeutic use of antibiotics in animal feeds is that “super-bugs” are able to evolve. This is a threat to both the health of the animals and humans. What a “super-bug” refers to is a strain of bacteria that has evolved to be resistant to bacteria and lethal to the host organism. These super-bugs account for the death of roughly 48,000 Americans each year (Adams, 2013). These superbugs proliferate in the digestive tracts of hosts. Each dose of antibiotics in the animals’ diets at sub-therapeutic levels increases the likelihood of antibiotic resistance bacteria to evolve. The antibiotics kill the antibiotic sensitive bacteria, but bacteria that are resistant proliferate in the gut of the animals. When these antibiotic resistant bacteria are left to grow in the gut, they can cause infection to the animal or people that consume the animal as food (Falco, 2013, Amachawadl et. al. 2013). Antibiotic-resistance can also be conferred through horizontal gene transfer and other methods, making the mere existence of such bacteria a threat that should not be taken lightly.
This turn of events presents us with an alarming problem. Strains of bacteria that are resistant to all prescribed antibiotics are beginning to appear. As a result, diseases such as tuberculosis and penicillin-resistant gonorrhea are reemerging on a worldwide scale (1). Resistance first appears in a population of bacteria through conditions that favor its selection. When an antibiotic attacks a group of bacteria, cells that are highly susceptible to the medicine will die.
Antibiotics have been vital tools in the fight against bacterial infections, however their effectiveness has waned in recent times due to the advent of antibiotic resistant strains of bacteria. According to a review by P, the uses of antibiotics, as well as influences from the environment have allowed such bacterial strains to respond to changes in their environment rapidly, and so develop resistance. This acquired ability can have serious and broad implications in the medical field, evident in a study by O into the resistance of intestinal Staphylococcus aureus.
The most effective way to combat pathogenic bacteria which invade the body is the use of antibiotics. Overexposure to antibiotics can easily lead to resistant strains of bacteria. Resistance is dangerous because bacteria can easily spread from person to person. Simple methods for preventing excessive bacterial spread are often overlooked. Not all preventative measures are even adequate. Doctors and patients often use antibiotics unnecessarily or incorrectly, leading to greater resistance. Antibiotics are used heavily in livestock and this excessive antibiotic use can create resistant bacteria and transfer them to humans. In order to reduce resistant bacteria,
Every year, antibiotic-resistant bacteria are threatening more and more people. As much of a problem as it is, many people are not educated on the term drug resistance. Since it is such a growing concern, it becomes confusing as to why drug resistance is occurring and what can be done to prevent it. Because drug resistance is such a health problem, determining what it is, how these bacteria can acquire the antimicrobial agents, and the possible solutions to the resistance are the types of actions that need to be taken in order to have a better understanding of how truly powerful these drug resistant bacteria are.
Syphilis is a sexually transmitting infection caused by Treonema pallidum, a gram negative, and anaerobic spirochete bacteria 1. Syphilis is thought to have been brought to Europe by Columbus and his sailors in the 1500’s 1. The disease is characterized by four different stages with varying symptoms depending on the stage that the disease is in1. Often syphilis is presented with another sexually transmitted infection such as chlamydia. Public education regarding safe sex is important for the prevention of this sexually transmitted infection.
Exposure to antimicrobials fundamentally alters microbial ecosystems of humans, animals and the environment, which may lead to the development of antimicrobial resistance.
There are many medical professionals who believe that the rise of antibiotic resistance is a result of the overuse and misuse of antibiotics. Dr. Jim Wilde, a paediatric emergency medicine physician at the Medical College of Georgia believes that the medical profession is losing the war against resistance...