What´s Chronic Traumatic Encephalopathy (CTE)?

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Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease attributed to single, sporadic, or repetitive brain trauma, including concussions and subconcussive hits (Baugh et al., 2012; Wortzel et al., 2013). This disease was originally referred to as dementia pugilistica, and nicknamed “punch drunk,” because individuals suffering from this disorder would present symptoms that were similar to someone’s mannerisms while being intoxicated (Wortzel et al., 2013). This “drunken” behavior is thought to be attributed to the cognitive, mood, and behavioral alterations as a result of the repetitive hits to the brain over an extended period of time. Because individuals suffering from this disease are often exposed to conditions that allow them to sustain blows to the head multiple times, the populations most often examined in these studies are athletes (football, boxing, rugby) and/or individuals in the military (McKee et al., 2009). Individuals can be symptom free for several years (Baugh et al., 2012). The onset of symptoms are sometimes seen about eight to ten years after an individual retires from their sport, which roughly equates to someone aged thirty to fifty yeas old (Baugh et al., 2012; Wortzel et al., 2013; Karantzoulis and Randolph, 2013). As with all diseases, symptoms can range from mild to severe. Researchers have found a positive correlation between the number of brain injuries sustained during a length of time playing a sport and the severity of symptoms (McKee et al., 2009).
The specific brain regions affected by CTE are often debated, but some of the areas most commonly agreed upon to show deterioration are: limbic system (thalamus, hypothalamus, amygdala, mammillary bodies), hippocampus, cerebral cortex, fron...

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...pic is relatively new, there needs to be more reliable, objective, and longitudinal studies conducted so researchers can gain a more concrete understanding of the disease’s natural course and symptoms (Karantzoulis and Randolph, 2013; Wortzel et al., 2013).
Chronic Traumatic Encephalopathy, previously referred to as dementia pugilistica, can be understood as a tauopathic, neurodegenerative and neuropsychiatric disease. While there is no neurobiological or neuropathological explanation as to why CTE occurs, the majority of researchers believe the disease is strongly related to previous head injuries. An individual suffering from CTE will most likely experience changes in their mood, behavior and cognition. Because this is a relatively new area of research, there are still a vast amount of unknowns pertaining to the disease’s symptoms, pathology, and natural course.

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