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Conclusion on gene therapy
Gene therapy medical implications essay
Gene therapy medical implications essay
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Gene Therapy is a modern treatment which uses genes to treat or prevent genetic diseases. It is a process of which DNA is used as a drug to treat a disease by delivering therapeutic DNA into a patients cell. The mutated gene is replaced by a healthier, functional/therapeutic gene which corrects and converts the cells lacking in protein or faultiness. Our future is based behind our genes in the body and scientists are trying to move away from drugs as a solution. Gene therapy is revolutionising the world of medicine and it could be the biggest and most helpful treatment created.
Gene Therapy is designed to insert genetic material into abnormal genes. When a gene is inserted direct to cell it will not function so a carrier 'The Vector'- a genetically engineered DNA molecule is used to deliver and welcome the new type of gene into the body to fight the disease. A mutated gene can cause the protein that is needed to be missing or faulty, Gene Therapy can introduce a healthier and brand new copy of the gene to reset the function of protein. A virus is used as a vector, delivering the gene by being inserted directly into the specific tissue in the body, where it is taken up by individual cells. Alternatively, a sample of the patients cell can be removed and exposed to the vector in a laboratory. If treatment it successful, new gene delivered by the vector will make a functioning protein. Researchers and scientists have many technical trials before treating a patient. However through the whole process the body must stay in control. This type of treatment should be further developed as doctors can treat diseases by inserting a gene into a persons cell. This prevents having surgery or using drugs. Gene Therapy treats many diseases such a...
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... clinical trials in the US. Gene Therapy is still under development however does have the potential to cure genetic conditions. It is currently an experimental discipline and much research remains to be done before it becomes a common issue. Between 1989 and 2010, 1698 clinical gene therapy trials were approved worldwide and less than 1% of these have shown clinical benefit.
The rise of Gene Therapy will create a new era where companies will compete with each other for the development of cheaper and more efficient gene therapy technologies.
More jobs from these companies upgrading technology for gene therapy will be employing more workers for development and competition.
Technology of Gene Therapy will get cheaper so more middle class people can afford treatment.
Insurance companies may start to cover Gene Therapy treatment costs however fees could increase.
In the late twentieth century, the field of biotechnology and genetic engineering has positioned itself to become one of the great technological revolutions of human history. Yet, things changed when Herber Boyer, a biochemist at the University of California, founded the company Genentech in 1976 to exploit the commercial potential of his research. Since then the field has exploded into a global amalgam of private research firms developing frivolous, profit-hungry products, such as square trees tailor-made for lumber, without any sort of government regulation.
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
In this paper, I will argue that genetic therapies should be allowed for diseases and disabilities that cause individuals pain, shorter life spans, and noticeable disadvantages in life. I believe this because everyone deserves to have the most even starting place in life as possible. That is no being should be limited in their life due to diseases and disabilities that can be cured with genetic therapies. I will be basing my argument off the article by “Gene Therapies and the Pursuit of a Better Human” by Sara Goering. One objection to genetic therapies is that removing disabilities and diseases might cause humans to lose sympathy towards others and their fragility (332). However, I do not believe this because there are many other events and conditions in society that spark human compassion and sympathy towards others.
Gene therapy is reinserting certain genes that helps deal with genetic diseases. There are three basic forms of this gene therapy. The first is Gene Inactivation Therapy in which the transferred gene neutralizes the proteins and evens out the amount or rids of the defective proteins. Another type is Gene Augmentation Therapy where the original form of the gene or the normal form of the gene is inserted into one of the cell’s chromosomes. This procedure is used normally when a gene with little activity or a deleted gene is the cause for the genetic disease. The third type of gene therapy is Gene Replacement Therapy. This form is used when the genetic disease involved specific genes that are necessary for proper functioning. The normal gene being put in place of the mutant gene accomplishes this form of gene therapy.
Just as there are different types of people who look at one glass of water and describe it as half full or half empty, the public has many different views on the future of our society. Gene therapy is also a glass that can be viewed in different angles – different perspectives. Some say it has great potential to shape the ideals of our future, while others believe it signifies intolerance for disabilities, imperfections that supposedly deplete from a person’s interests, opportunities and welfare (quoted by Peter Singer, xviii). This global issue has brought people with different opinions in the open, arguing their views using history, morality and foresight.
Gene therapy works in three ways; it works to replace a missing or defective gene with a normal one, replace a faulty gene so that it will function properly and it works to activate and deactivate a gene, allowing it to “switch” on and off. Gene therapy is done by the deliverance of a gene to a cell via a carrier, or vector, such as a virus. Scientists lean more towards using a virus because they can seek out particular cells and transfer pieces of deoxyribonucleic acid into them. Scientists also take advantage by deactivating their harmful characterizes and modifying them to carry particular gene into designated cells. After gene therapy is done, the genes can then stimulate the production needed for standard functioning, allowing that gene to return to its previous normal state. Therefore, if a patient were to be in the beginning stages of cancer, gene therapy would seek out the cancerous gene and replace it with a healthy one and minimizes the disease from
Gene therapy gives people who suffer from genetic diseases a chance to lead a normal life. Dangerous diseases, such as AIDS, SCID, Thalassemia and ADA can be cured successfully. In September 5, 2006, two people with advanced melanoma received Gene therapy and they got recovery soon. This is a breakthrough in cancer gene therapy. Gene therapy uses patients own cells to cure diseases, and, therefore, no rejection to their bodies. Furthermore, patients could get permanent cure from gene therapy without recurrence.
Gene therapy is a provisional technique that is the insertion of normal genes into the cells where there is a missing or miscoded gene to fix a genetic disorder. In the 1960s and early 1970s,
Michael Crichton in “Patenting Life”and John E. Calfee in “Decoding The Use Of Gene Patents” discuss Gene Patent. Although the authors agree that the test for cancer is too expensive, the authors have different views about how much each patient should pay for medical expenses and who should get the better treatment by the cancer they have. Gene patents is very dangerous, but also very expensive to care for unfortunately. Test for breast cancer now costs $3,000 “Crichton”(441). Now because of it costing so much, they have had six lawsuits by 2008 “Calfee” (445).
Gene therapy focuses on the replacement of defective genes with modified functioning genes. Many diseases are caused by a defective gene meaning the body is incapable of producing essential proteins or enzymes. In its simplest form, gene therapy aims to identify the defective gene and fix this gene with the replacement of a normal gene (Senn).
"The aim is to decrease the fear of a brave new world and to encourage people to be more proactive about their health. It [Gene therapy] will help humans become better physically and even mentally and extend human life. It is the future” (Hulbert). Dr. Hulbert, a genetic engineer, couldn’t be anymore right; more time, money, and research needs to be put into gene therapy and genetic engineering, since it can cure certain illness and diseases that are incurable with modern medicine, has fewer side-effects than conventional drugs or surgery, and allows humans to be stronger physically and mentally at birth. Gene therapy or genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population (NIH). It essentially means that we can change DNA to make an organism better. Genetic engineering is used with animals and plants every day; for example with genetic...
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Gene therapy enables patients to survive incurable diseases. In the field of genetic diseases, ADA-SCID, CGD and hemophilia are three main ones. ADA-SCID is known as the bubble boy disease. CGD is related to immune system that would lead to fungal infections which are fatal. Patients with Hemophilia are not able to induce bold bleeding (Gene therapy for diseases, 2011). Gene therapy also has good effects on cancer treatment and neurodegenerative diseases, which include Parkinson’s disease and Huntington’s disease. Viral infections, including influenza, HIV and hepatitis can also be treats by it (Gene therapy for diseases, 2011). According to the Science Daily in 2011, gene therapy now can apply to heart failures and neurologic diseases as well.
The purpose of this document is to learn about the new and exciting developments in the biotech industry. Besides lives being effected, the companies and the markets in which they reside will be as well. It’s vitally important to learn about the new technologies since there is a very good chance that million’s of others, and mostly likely yours truly will ingest a new drug, or have a new procedure preformed.
Position Paper: Gene Therapy in Humans. Advancements in science and medicine are usually accompanied by a myriad of ethical and moral implications. The fairly recent advancement in genetics, called gene therapy, is no exception to the baggage of polarizing views that come with new technology. Gene therapy is an extremely hot topic in both the scientific world and everyday life. New technology, discoveries, and breakthroughs are rapidly occurring in the field every day.