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Issues surrounding gene therapy
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Gene Therapy
Gene therapy is a method used by doctors that ‘uses genes as medicine’. It repairs faulty or damaged gene copies by transferring a therapeutic or working gene into specific parts of faulty gene copy. This means that gene therapy can be used to replace a faulty gene or to introduce a new gene whose function is to modify the clinical course of a condition or to cure a problem in the gene (Refer to image 2). Image 1 shows how gene therapy is completed using an adenovirus vector while image 2 explains the method of gene therapy and shows how cells are removed, altered and injected back into the patient. Gene therapy has potential to treat and cure many medical conditions such as various types of cancer, degenerative diseases and viral infections such as AIDS. Research into gene therapy still needs to be done before this approach to the treatment of certain conditions will realise its full potential. Trials are being conducted in the United States and Europe and a modest number initiated in other countries, including Australia. The majority of these trials are focussing on treating acquired conditions such as cancer (European Society of Gene & Cell therapy, 2011).
A genome is the make up of all the genetic material in an organism. It is the entire hereditary instructions for building, running and maintaining an organism and also transferring DNA onto offspring (Refer to image 3). The genome in most organisms is made up of a chemical called Deoxyribonucleic acid (DNA). Genes are a set of instructions that determine what the organism is like, in its environment . Genes are found in the genome. The genome is made up of three components; chromosomes, which contain genes, which are m...
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...the little things wrong with them; try and become super humans.
In future times, gene therapy will become more popular and companies will be competing with each other for the development of the cheaper, more trust worthy and more efficient gene therapy technologies. Future technology that performs the gene therapy treatment will most likely become gradually cheaper overtime so that the average middle class person will be able to afford gene therapy. Insurance companies may also start allowing their services to cover for the cost of gene therapy (Issues and Impacts, 2014).
In summary, gene therapy clearly has benefits if it successfully treats diseases and allows people to lead normal and productive lives. There are still some problems associated with gene therapy but hopefully research can overcome these problems and make gene therapy more reliable and cheaper.
DNA is the genetic material found in cells of all living organisms. Human beings contain approximately one trillion cells (Aronson 9). DNA is a long strand in the shape of a double helix made up of small building blocks (Riley). The repeat segments are cut out of the DNA strand by a restrictive enzyme that acts like scissors and the resulting fragments are sorted out by electrophoresis (Saferstein 391).
DNA (Deoxyribonucleic acid) is a molecule found in in the nucleus of all cells in the body which carries our genetic information. DNA is found in the form of chromosomes, with a total of 23 pairs in the human body1. DNA holds the genetic coding for all our characteristics, i.e. our eye colour, body shape, and how we interact with others on a daily basis.
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
In this paper, I will argue that genetic therapies should be allowed for diseases and disabilities that cause individuals pain, shorter life spans, and noticeable disadvantages in life. I believe this because everyone deserves to have the most even starting place in life as possible. That is no being should be limited in their life due to diseases and disabilities that can be cured with genetic therapies. I will be basing my argument off the article by “Gene Therapies and the Pursuit of a Better Human” by Sara Goering. One objection to genetic therapies is that removing disabilities and diseases might cause humans to lose sympathy towards others and their fragility (332). However, I do not believe this because there are many other events and conditions in society that spark human compassion and sympathy towards others.
A gene is a sequence of DNA that is used by cells to create protein. It has all of the information needed to make a protein. It knows when to make these protein and where to begin and end. The functions of a cell are then carried out by the proteins.
There have been four somewhat recent successful gene therapy treatments. The four deal with correcting hemophilia, bone marrow transplants, skin cancer, and vessel growth. In the success with the bone marrow transplants, French researchers collected bone marrow cells from patients, used gene therapy to correct the bone marrow, and then returned the bone marrow to the patient. This was 80% successful as reports 16 months after the transplants showed. Squamous cell carcinoma, skin cancer of the head and neck, was treated using gene therapy as well. The fourth trial was where DNA was used to carry a substance that stimulates blood vessel growth to damaged heart tissue and in this trial there was much success noted.
Gene therapy works in three ways; it works to replace a missing or defective gene with a normal one, replace a faulty gene so that it will function properly and it works to activate and deactivate a gene, allowing it to “switch” on and off. Gene therapy is done by the deliverance of a gene to a cell via a carrier, or vector, such as a virus. Scientists lean more towards using a virus because they can seek out particular cells and transfer pieces of deoxyribonucleic acid into them. Scientists also take advantage by deactivating their harmful characterizes and modifying them to carry particular gene into designated cells. After gene therapy is done, the genes can then stimulate the production needed for standard functioning, allowing that gene to return to its previous normal state. Therefore, if a patient were to be in the beginning stages of cancer, gene therapy would seek out the cancerous gene and replace it with a healthy one and minimizes the disease from
...s of gene therapy is that the mortality rate is very high. This is because Immune system may attack cells and cells may attack vital organs. Furthermore, ethical issues should be dealt in a positive way. The technological institute has to reduce the unnecessary expenses of the treatment. I highly suggest the government investing more money on the development of gene therapy.
Introduction DNA is the molecule that is responsible for the storing and replicating of genetic material for an organism. The genetic material is the thing that gives an organism its identity. DNA is in the shape of a double helix. It consists of a phosphate group, deoxyribose, and a nitrogenous base. The phosphate groups are synthesised together to create an ester.
"The aim is to decrease the fear of a brave new world and to encourage people to be more proactive about their health. It [Gene therapy] will help humans become better physically and even mentally and extend human life. It is the future” (Hulbert). Dr. Hulbert, a genetic engineer, couldn’t be anymore right; more time, money, and research needs to be put into gene therapy and genetic engineering, since it can cure certain illness and diseases that are incurable with modern medicine, has fewer side-effects than conventional drugs or surgery, and allows humans to be stronger physically and mentally at birth. Gene therapy or genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population (NIH). It essentially means that we can change DNA to make an organism better. Genetic engineering is used with animals and plants every day; for example with genetic...
“A gene is a segment of DNA or a sequence of nucleotides in DNA that code for a functional product,” Tortora. Microbiology. p. 575. The syllable of the syllable. These genes not only affect our outlook, but also play a role.
Genes are DNA. DNA stands for deoxyribonucleic acid. Genes help make everybody look and function differently. Genes code for proteins. Genes have many different characteristics. People get their body features from their parents. If a father is tall, and the mother is
"We used to think that our fate was in our stars, but now we know that, in large measure, our fate is in our genes, "quotes James Watson. This fate that Watson is talking about is contained in our genes, and deals with a new technique, gene therapy. Gene therapy is revolutionizing the world of medicine. Many physicians are predicting that in twenty years gene therapy may change the practice of medicine from a treatment-based to a prevention-based practice. Our future is l ocked away inside of our genes. Gene therapy is unlocking these doors. Researchers are starting to move away from developing new drugs, and towards finding an ultimate solution. That solution is to use gene therapy as a treatment for many genetic diseas es. Researchers hope that in the coming years, every genetic disease will have gene therapy as its treatment. Gene therapy could be the last therapy that the human race will ever need.
DNA- A nucleic acid that carries the genetic information in the cell and is capable of self-replication and synthesis of RNA. DNA consists of two long chains of nucleotides twisted into a double helix and joined by hydrogen bonds between the complementary bases adenine and thymine or cytosine and guanine. The sequence of nucleotides determines individual hereditary characteristics.
What are the risks and what are the possible benefits? Currently, gene therapy is one of the only ways to change the genetic makeup of an animal or human. Also, the chance of gene therapy being successful in animals is fifty percent, while in humans it is five percent. Human Genetics Alert believes “Once we begin to consciously design ourselves, we will have entered a completely new era of human history, in which human subjects, rather than being accepted as they are, will become just another kind of object, shaped according to parental whims and market forces”. HGA provides background information on the currently available resources used in Genetic Engineering.