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Control mechanisms for blood glucose
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Essay 1: Indirect Calorimetry Indirect Calorimetry estimates the energy expenditure of the human body through measurements of expelled gases. Indirect calorimetry is not quite as accurate as direct calorimetry, which takes measurements of heat dissipated from the human body using heavy equipment, but it is less expensive to conduct experimentally, and provides one with the ability to measure oxygen consumption and carbon dioxide production. With these measurements, one gets a look into the overall aerobic physical fitness of the individual and their maximum oxygen uptake. Indirect calorimetry can also determine the primary source of energy being used using the Respiratory Exchange Ratio (RER). RER is non-invasive and provides information regarding the metabolic contribution of fat or carbohydrates. The idea is that one is constantly consuming and expelling air, so the difference between the oxygen inspired and expired over a given time frame would yield the total volume of oxygen consumed, VO2, because the expired air will contain less oxygen than the inspired air, the opposite being true with the air's carbon dioxide concentration. Most exercise physiology laboratories feel it is more cost-effective to only have one ventilation system, so while the oxygen …show more content…
Insulin is stimulated by an increase in plasma glucose concentration. It's role pertains to decreasing those blood glucose levels by increasing the use of glucose as fuel or the storage of fat in adipose tissue. Whereas insulin targets most cells of the body, glucagon primarily targets the liver in particular. It comes into play when low glucose concentrations are detected by the sympathetic nervous system. Glucagon is responsible for the stimulation of glucose production from non-sugar substrates and the breakdown of glycogen into glucose so it can be further metabolized for energy production, or gluconeogenesis and glycogenolysis
The respiratory system is responsible in regulating gas exchange between the body and the external environment. Differences in respiration rate indirectly influence basal metabolic rate (BMR) by providing the necessary components for adenosine triphosphate (ATP) formation (Williams et al., 2011). Observation of gas exchange were measured and recorded for two mice (mus musculus) weighing 25 g and 27 g under the conditions of room temperature, cold temperature (8°C), and room temperature after fasting using a volumeter. The rates of oxygen consumption and carbon dioxide production were measured and used to calculate BMR, respiratory quotient (RQ) and oxidation rate. The mouse at room temperature was calculated to have a BMR of 2361.6 mm3/g/hr. Under conditions of cold temperature and fasting, the BMR values decreased to 2246.4 mm3/g/hr and 2053.2 mm3/g/hr respectively. Rates of glucose oxidation increased under these treatments while rates of fat oxidation decreased. Respiratory quotient (RQ) values were calculated to determine the fuel source for metabolic activity. On a relative scale, protein or fat appeared to be the primary fuel source for all three treatments although the mouse at 8°C had the highest RQ and may have relatively used the most glucose. It was also concluded that BMR in mice are greater than in humans.
•While exercising your lungs tries to increase the intake of oxygen as well as release the carbon dioxide.
In this lab, we explored the theory of maximal oxygen consumption. “Maximal oxygen uptake (VO2max) is defined as the highest rate at which oxygen can be taken up and utilized by the body during severe exercise” (Bassett and Howley, 2000). VO2max is measured in millimeters of O2 consumed per kilogram of body weight per min (ml/kg/min). It is commonly known as a good way to determine a subject’s cardio-respiratory endurance and aerobic fitness level. Two people whom are given the same aerobic task (can both be considered “fit”) however, the more fit individual can consume more oxygen to produce enough energy to sustain higher, intense work loads during exercise. The purpose of this lab experiment was performed to determine the VO2max results of a trained vs. an untrained participant to see who was more fit.
Animal metabolism consists of the utilization of nutrients absorbed from the digestive tract and their catabolism as fuel for energy or their conversion into substances of the body. Metabolism is a continuous process because the molecules and even most cells of the body have brief lifetimes and are constantly replaced, while tissue as a whole maintains its characteristic structure. This constant rebuilding process without a net change in the amount of a cell constituent is known as dynamic equilibrium (Grolier1996). In the combustion of food, oxygen is used and carbon dioxide is given off. The rate of oxygen consumption indicates the energy expenditure of an organism, or its metabolic rate (Grolier1996).
Heart rate is an indicator to demonstrate the intensity and duration of exercise. The aerobic system falls under the aerobic threshold. The aerobic threshold is “the heart rate above which you gain aerobic fitness, at 60% of our MHR.” (Bbc.co.uk, 2018). Towards the end of the Aquathon the aerobic system can no longer keep with the intensity, so the anaerobic threshold begins in the last few minutes of exercise. The anaerobic threshold “is the heart rate above which you gain anaerobic fitness. You cross your anaerobic threshold at 80% of your MHR.” (Bbc.co.uk, 2018). The anaerobic systems function without the use of oxygen. “They burn through ATP and then turn to anaerobic glycolysis, using glucose and glycogen for fuel with a by-product of lactate.” (Verywell Fit, 2018). When working anaerobically it creates oxygen debt and can only continue to keep working for a few minutes. Oxygen Debt is the oxygen consumption post exercise to replenish creatine
This is monitored by the cells within the Islets of Langerhans, which is located in the control (the pancreas). After skipping a meal or tough physical exercise blood glucose concentration decreases. Alpha cells in the islets detect this drop and are stimulated to secrete glucagon. Glucagon is a polypeptide hormone which influences an increase in blood glucose concentration. Glucagon travels through the bloodstream until it reaches glucagon receptors which are predominantly found in the liver, as well as, the kidneys. Glucagon stimulates the breakdown of stored glycogen to be released into the bloodstream as glucose. It also stimulates the conversion of amino acids into glucose and the breakdown of fat into fatty acids. These effectors cause an increase in blood glucose levels back towards the normal. This increase in blood glucose concentration is detected by the alpha cells which then stop the secretion of
Our body obtains the energy by digesting the carbohydrates into glucose. Volumes of glucose are required by the body to create ATP. ATP is short for 'Adenosine Triphosphate ' and is an energy carrier. When we consume too many carbohydrates our body produces a lot of glucose and as a result blood glucose levels rise and sometimes they may rise over the normal range of blood glucose concentration. To bring it back within the healthy range, the homeostatic system of blood glucose regulation is used. The blood flows through the pancreas where the beta cells, receptors, detect the high blood glucose level. To counteract this stimuli beta cells alert the control centre, which are also the beta cells located in the islets of Langerhans in the pancreas. The secretion of insulin has to be done quickly but can only be carried out when insulin gene is switched on. Turning on the insulin gene switch can take 30 minutes to an hour therefore, the production of insulin by beta cells are done in advance and are packaged in vesicles right until blood glucose rises. Glucose comes into the beta cell to trigger the vesicle that contains the insulin to move towards the plasma membrane and fuse. This releases the insulin into the bloodstream where they are distributed throughout the body and only affect specific target cells. The receptor, a protein, on the target cell’s plasma membrane recognises and connects
Insulin: a hormone made by the pancreas that allows your body to use sugar (glucose) from carbohydrates in the food that you eat for energy or to store glucose for future use. Insulin helps keeps your blood sugar level from getting too high (hyperglycemia) or too low (hypoglycemia). Before insulin Diabetes mellitus was a chronic disease that affected thousands of people in Canada and beyond. In the first half of the 20th century, medical professionals understood that diabetes mellitus involved the body’s inability to metabolize food, especially carbohydrates. “Insuline” was already in development as many medical professionals like Joseph Freiherr and Oscar Minkowski, isolated its properties before Banting had his ideas. As well Ancient Greek
McKenzie, D. C. (2012). Respiratory physiology: Adaptations to high-level exercise. British Journal of Sports Medicine, 46(6), 381. doi:10.1136/bjsports-2011-090824
After the water, has been boiling for 10 minutes, and the temperature inside the test tube has been stable for 5 minutes, record the temperature and remove the thermometer.
Blood glucose levels are the measurement of glucose in an individual’s blood. This is important because glucose is the body’s main source of fuel and the brains only source of fuel. Without energy from glucose the cells would die. Glucose homeostasis is primarily controlled in the liver, muscle, and fat where it stored as glycogen. The pancreas is also a significant organ that deals with glucose. The pancreas helps regulate blood glucose levels. Alpha-islet and beta-islet pancreatic cells measure blood glucose levels and they also regulate hormone release. Alpha cells produce glucagon and beta cells produce insulin. The body releases insulin in response to elevated blood glucose levels to allow the glucose inside of cells and
The pancreas uses these two hormones in order to monitor blood glucose levels. After a meal, blood glucose usually rises. This is when insulin secretion will start (Nussey S, Whitehead S. “Endocrinology: An Integrated Approach”). Consequently, blood glucose decrease to the normal range. This is how insulin maintains blood levels when is high. However, when blood level falls below normal range, glucagon comes into play. Low blood glucose occurs usually when hungry and during exercise. This will then triggers glucagon secretion. When blood level falls, the body goes into imbalance. Hence is why in order to maintain homeostasis glucagon is crucial. The body will tell the pancreas to increase more glucose and the pancreas will secrete glucagon by taking glycogen from the liver to produce glucose. The glucose will produce energy and will make blood glucose concentration increase (Homeostasis of Insulin and Glucose, Abpischools.org). When the pancreas cannot maintain homeostasis, many problems will arise in the body. When the pancreas fails to produce insulin, type 1 and 2 diabetes can occur. For those with type 1 diabetes, insulin injections will be needed in order to regulate blood glucose level, otherwise, glucose levels will be out of control. For type 2 diabetes, they are not insulin dependent like type 1, however, the body does not create enough in the body. When blood glucose
Investigating Heat Loss From a Container Planning We are investigating heat loss from a container and how it is affected. We could change: Room temperature Surface area Amount of water Use a lid Insulate around it Colour of tin We could measure / observe: Amount of time Temperature We will change: Surface area We will measure / observe: Temperature (every minute for 5 minutes) Our question is: Does surface area effect the rate of heat loss? We will keep these the same: Colour of tin Room temperature Amount of water Use a lid Insulate around it Preliminary investigation = == ==
Patient will display adequate gas exchange as evidence by SaO2 values and respiratory rate consistent with baseline.
Heat energy is transferred through three ways- conduction, convection and radiation. All three are able to transfer heat from one place to another based off of different principles however, are all three are connected by the physics of heat. Let’s start with heat- what exactly is heat? We can understand heat by knowing that “heat is a thermal energy that flows from the warmer areas to the cooler areas, and the thermal energy is the total of all kinetic energies within a given system.” (Soffar, 2015) Now, we can explore the means to which heat is transferred and how each of them occurs. Heat is transferred through conduction at the molecular level and in simple terms, the transfers occurs through physical contact. In conduction, “the substance