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Pancreas Anatomy
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The pancreas is one of the essential organs in the human body and belongs in the Digestive system. Out of all the internal organs, the pancreas is unique because the pancreas plays a role in both the endocrine gland and the exocrine gland. This means that the pancreas is a dual function gland in which is the reason why the pancreas is such a vital part of the digestive system. This research paper will talk about the anatomy, physiology, and the important functions the pancreas play to maintain homeostasis. The pancreas is Located in the upper abdomen posteriorly to the stomach and next to the small intestines. In the average adult, the pancreas is approximately 6-10 inches long and 2 inches wide. The pancreas has three regions: the head, the …show more content…
The exocrine function of the pancreas is that it produces enzymes that aids in the digestion of food. There are three important enzymes that are crucial in helping with digestion. The first digestive enzyme is amylase. Amylase function is to break down carbohydrates. The amylase enzyme is made in two places: the cells in the digestive tract that produces saliva and the main one specifically found in the pancreas that are called the pancreatic amylase (Marie, Joanne; Media Demand, “What Are the Functions of Amylase, Protease and Lipase Digestive Enzymes”). The amylase in the pancreas passes through the pancreatic duct to the small intestines. This amylase in the pancreas completes the process of digestion of carbohydrates. Consequently, this leads to the production of glucose that gets absorbed into the bloodstream and gets carried throughout the body. The next enzyme that aids in digestion of food is protease. While amylase breaks down carbohydrates, protease breaks down protein. Protease breaks down protein into the building block form of amino acids. The three main proteases that it produces are: pepsin, trypsin and chymotrypsin (Marie, Joanne; Media Demand, “What Are the Functions of Amylase, Protease and Lipase Digestive Enzymes”). Pepsin does not occur in the pancreas but it is the catalysis in starting the digestion of proteins. Trypsin and chymotrypsin are the two proteases that occur in …show more content…
The pancreas uses these two hormones in order to monitor blood glucose levels. After a meal, blood glucose usually rises. This is when insulin secretion will start (Nussey S, Whitehead S. “Endocrinology: An Integrated Approach”). Consequently, blood glucose decrease to the normal range. This is how insulin maintains blood levels when is high. However, when blood level falls below normal range, glucagon comes into play. Low blood glucose occurs usually when hungry and during exercise. This will then triggers glucagon secretion. When blood level falls, the body goes into imbalance. Hence is why in order to maintain homeostasis glucagon is crucial. The body will tell the pancreas to increase more glucose and the pancreas will secrete glucagon by taking glycogen from the liver to produce glucose. The glucose will produce energy and will make blood glucose concentration increase (Homeostasis of Insulin and Glucose, Abpischools.org). When the pancreas cannot maintain homeostasis, many problems will arise in the body. When the pancreas fails to produce insulin, type 1 and 2 diabetes can occur. For those with type 1 diabetes, insulin injections will be needed in order to regulate blood glucose level, otherwise, glucose levels will be out of control. For type 2 diabetes, they are not insulin dependent like type 1, however, the body does not create enough in the body. When blood glucose
This is monitored by the cells within the Islets of Langerhans, which is located in the control (the pancreas). After skipping a meal or tough physical exercise blood glucose concentration decreases. Alpha cells in the islets detect this drop and are stimulated to secrete glucagon. Glucagon is a polypeptide hormone which influences an increase in blood glucose concentration. Glucagon travels through the bloodstream until it reaches glucagon receptors which are predominantly found in the liver, as well as, the kidneys. Glucagon stimulates the breakdown of stored glycogen to be released into the bloodstream as glucose. It also stimulates the conversion of amino acids into glucose and the breakdown of fat into fatty acids. These effectors cause an increase in blood glucose levels back towards the normal. This increase in blood glucose concentration is detected by the alpha cells which then stop the secretion of
Homeostasis is the biological process that maintains a stable internal environment despite what occurs in the external environment. Chemicals and bodily functions are maintained in a balanced state so the body may function optimally. There are various systems in the human body that require maintenance through the processes of biochemical checks and balances so they may function properly. One of these systems includes the rise and fall of blood glucose and is under the control of the homeostatic regulation process. Homeostasis is essential in blood glucose regulation as high blood glucose levels (hyperglycaemia) and low blood glucose levels (hypoglycaemia) are dangerous and can affect the human body in many ways and can also lead
The pathophysiology of diabetes mellitus in is related to the insulin hormone. Insulin is secreted by cells in the pancreas and is responsible for regulating the level of glucose in the bloodstream. It also aids the body in breaking down the glucose to be used as energy. When someone suffers from diabetes, however, the body does not break down the glucose in the blood as a result of abnormal insulin metabolism. When there are elevated levels of glucose in the blood, it is known as hyperglycemia. If the levels continue to remain high over an extended period of time, damage can be done to the kidneys, cardiovascular systems; you can get eye disorders, or even cause nerve damage. When the glucose levels are low in one’s body, it is called hypoglycemia. A person begins to feel very jittery, and possibly dizzy. If that occurs over a period of time, the person can possibly faint. Diabetes mellitus occurs in three different forms - type 1, type 2, and gestational.
Insulin is a hormone that is produced by specialized cells on the surface of the pancreas called pancreatic islets or Islets of Langerhans. It causes changes to occur in the plasma membrane of the cell that cause the cell to pull in glucose from the blood stream. The hormonal counterpart of insulin is glycogon, which serves to promote the rele...
The pancreas is an elongated and flattened gland located within the abdomen. Not only is it a vital part of the digestive system, but it is also a key controller of blood sugar levels. (The Pancreas). The pancreas has been divided into four regions which are the head, neck, body, and tail. Being the widest part of the pancreas, the head is twenty-three millimeters. The part of the head that hooks towards the back of the abdomen is the uncinate (Chronic Pancreatitis Imaging). Between the head and body of the pancreas is the neck, which is about nineteen millimeters. The body of the pancreas is twenty millimeters, between the neck and the tail. The tail is the smallest part of the pancreas, measuring at only fifteen millimeters. (Parts of the Pancreas). The length of the pancreas in total ranges from four point seven to seven point one inches. The pancreas also weighs from seventy to one-hundred grams (How does the Pancreas Work?).
Throughout the whole of the United Kingdom, between 2 and 3 of every 100 people have a known form of diabetes (DTC, 2004). What is diabetes? Explained simply, it is a disease in which the body does not produce or properly use insulin. In the normal state of glucose function, there is a stable release and uptake of glucose, regulated by two hormones produced in the pancreas, glucagon and insulin. There are two distinct mechanisms which give rise to the abnormal blood glucose levels seen in patients with type I and type II diabetes. In type I diabetes, a deficiency in insulin production at the pancreas results in elevated blood glucose levels due to the lack of hormonal regulation. In type II diabetes, although the pancreas produces regular levels of insulin, the body resists the effect of insulin, inhibiting the ability of insulin to break down glucose in the blood. Because of the inherent differences in the biochemical mechanisms of these two diseases, the characteristics associated with type I and type II diabetes are very different. The typical onset of type I diabetes is usually ...
The pancreas can be divided into two sections when studying the histology. The pancreas has exocrine and endocrine functions, each with unique cell types. The exocrine pancreas serves to secrete digestive enzymes into the duodenum. Some of the specific enzymes and secreted substances are Proteases, lipase, amylase, bicarbonate, and water (Bowen, “Exocrine Secretions”). These enzymes are used to break down protein, fat, and carbohydrates respectively. The bicarbonate simply act as an acid buffer to prevent damage of the small intestine as the stomach acid must be neutralized. The enzymes are created in acinar cells and the bicarbonate is synthesized in epithelial cells surrounding pancreatic ducts (Bowen “Exocrine
The pancreas is a 6-inch long organ in the body, located behind the stomach in the abdomen. The pancreas contains exocrine and endocrine glands that produce pancreatic juices, insulin, and hormones. Pancreatic juices, also called pancreatic enzymes, are made by the exocrine glands and released into the intestines to help with digestion. Around 95% of the pancreas is exocrine glands and ducts. The endocrine part of the pancreas are arranged in small clusters of cells called islets of Langerhans. Islets of Langerhans release insulin and glucagon into the bloodstream and those two hormones manage the level of sugar in the blood. When these two hormones are not working like they are supposed to, it often results in diabetes.
Diabetes is a disease that causes an abnormally high level of sugar, or glucose, to build up in the blood. Glucose comes from food we consume and also from our liver and muscles. Blood delivers glucose to all the cells in the body. In people without diabetes, the pancreas makes a chemical called insulin which is released into the blood stream. Insulin helps the glucose from the food get into cells. When the pancreas doesn’t make insulin, it can’t get into the cells and the insulin stays in the blood stream. The blood glucose level gets very high, causing the person to have type one diabetes.
Pancreas- The pancreas creates a juice that breaks down carbohydrates, fats, and proteins. "The pancreas delivers digestive juice to the small intestine through small tubes called ducts" (NIH (5).) The pancreas is not considered part of the GI tract, but it is a necessary organ needed for the digestion and absorption of nutrients.
Imagine you are eating a sandwich containing wheat bread, ham, lettuce, and Swiss cheese. Do you ever wonder where the nutrients go from all of the previous listed ingredients? Well, when a bite of this sandwich is taken, the mouth produces a saliva enzyme called amylase. This enzyme immediately goes to work by breaking down the carbohydrates that are in the bread. Once, the bite is completely chewed, the contents then are swallowed and go down the esophagus and begin to head towards the upper esophageal sphincter and the is involuntarily pushed towards the stomach. The next passage for the sandwich is to go through the lower esophageal sphincter; which transports the sandwich into the stomach.
The pancreas is located in the middle of the abdomen. It’s surrounded by the stomach, small intestine, liver and spleen. It’s about six inches long and shaped like a thin pear, wide at one end. It has three sections: wider right end is the head, the middle is the body and the left end is the tail.
Blood glucose levels are the measurement of glucose in an individual’s blood. This is important because glucose is the body’s main source of fuel and the brains only source of fuel. Without energy from glucose the cells would die. Glucose homeostasis is primarily controlled in the liver, muscle, and fat where it stored as glycogen. The pancreas is also a significant organ that deals with glucose. The pancreas helps regulate blood glucose levels. Alpha-islet and beta-islet pancreatic cells measure blood glucose levels and they also regulate hormone release. Alpha cells produce glucagon and beta cells produce insulin. The body releases insulin in response to elevated blood glucose levels to allow the glucose inside of cells and
The pancreas, in addition to its digestive process has two important hormones, Insulin and Glucagon which are important for the maintenance of blood glucose level at a narrow range. Not only glucose, but also they are important for protein and lipid metabolism. Glucagon is secreted by the alpha cells of the islet of Langerhans and Insulin is secreted by the beta cells of Langerhans. Both are secreted to portal vein. (8)
Diabetes Mellitus is a disease in which the pancreas produces little or no insulin. Insulin is a hormone that helps the body’s tissues absorb glucose which is sugar, so it can be used as a source of energy. Glucose levels build up in the blood and urine which causes excessive urination, thirst, hunger, and problems with fat and protein metabolism in a diabetic person. Diabetes is very common in the United States; it is the seventh leading cause of all deaths. Women have been diagnosed with diabetes more than men. There are two forms of diabetes, Type one and Type two diabetes. Type one diabetes is when the body does not produce insulin or produces it in very small quantities. This usually occurs in younger people under twenty years of age, mostly around puberty. Type two diabetes is when the body’s balance between insulin production and the ability of cells to use insulin doesn’t work properly. This is more common than type one; about 90-95% people in the United States have it. There are no cures for diabetes now but there are many researchers investigating factors through new technologies to cure them. Meanwhile, technological advancements are being made to keep glucose at a good level for diabetes.