Hrm/531 Week 4

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As a QA Manager I would ensure that the following steps are followed in accordance with the ICH, GCP, HIPAA and FDA regulations and guidelines for clinical trial documentation management. a) Data Management System (DMS): Regulate the clinical data by enforcing stringent data management practices and mitigate the deviation in data collection and recording. The study protocol will define the source of data collection with Case Report Forms (CRFs), method of storage paper/ electronic and information retained for data archiving. Each subject will be identified with unique ID and Subject Identification Log will be maintained separately from trail analysis documents. The DMS prevents unblinding of specific documents, which protect the privacy and confidentiality of the subject, unless required by the study protocol. Identifiable documents and records will be maintained in accordance with the data retention period as specified in the protocol and the requirement of the regulations and IRB. Any update or changes implemented will be recorded in the revision history of the respective documents. The clinical trial team will be trained on clinical documentation and …show more content…

The data utilized for trial analysis are maintained anonymous, however the trial management data carry personal identifiers for conduct of study and to ensure patient safety. The patient source data is encrypted and password protected allowing access to authorized personnel and prevents transfer to electronic media device. The list of authorized personnel will be maintained in the Trial Master File. The audit trails captures all activities pertaining to conduct of clinical trials and tracks changes performed to data. The date and time stamp used impede chances of misuse. On completion of the trial, the data will be locked using DMS file locking facility to prevent tampering of

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