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Compare and contrast proto-oncogenes and tumor suppressor genes
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Cancer is a disorder where the body cells lose the ability to control growth. The cell cycle is a series of stages that happen within a cell that leads to division and duplication of DNA, that eventually produces two daughter cells. The development of this life changing disease occurs in the cell cycle, when checkpoints or regulations are ignored and the cell continues through the cycle. When a cell become damaged, it can lead to major problems.
The cell cycle begins with a phase called interphase, which includes G1, G0, and S, which are smaller stages within. G1 is the first gap phase where the cell increases in size, synthesize proteins, and produce RNA. At the end of this phase, there is a checkpoint, or internal regulator, that makes sure
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Cancer is related to the cell cycle because if a cell does not meant the checkpoint requirements and still continues through the cycle, it will become uncontrollable. During the synthesis stage of interphase, while the DNA should be replicating, an error can occur, which will lead to a mutated cell. Proteins that control transcription are often the cause because of the changed sequence. This one mutation can lead to an army of mutated cells. These cells can lead to tumor development and cancer. The P53 is a gene that codes for a protein that suppresses tumors. A tumor suppressor is a gene that protects a cell from one step on the path to cancer. It is extremely important in helping kill cells that could become cancerous. If there is a mutation to this gene, it will stop protecting you from cancer. Proto-oncogenes code for positive cell cycle regulators, but when mutated, turn into oncogenes, or genes that have the potential to become cancerous. Cancerous cells lose their specialized functions and produce more quickly. They ignore signals that tell them when to start and stop dividing. Eventually, they can take over tissues and grow without being regulated. Cancer cells have insufficient internal regulators and also cannot program cell death among mutated cells, this process is called apoptosis. When cancer cells don’t die, they keep dividing instead which can produce tumors, masses of rapidly dividing cells that can damage surrounding tissues. When cancer moves into other parts of the body and forms secondary tumors, it is called metastasis. Tumors that develop can be malignant, cancerous and invade and destroy healthy tissue, or benign, noncancerous and does not invade any other part of the body. Sometimes, cancerous cells can break away from a tumor and enter the bloodstream, which allows them to travel throughout the
Cell cycle events portray some differences between different living things. In all the three living things, their cells divide, a process referred to as mitosis. The mitosis stage differs and it encompasses four phases. During development, the cell cycle functions endlessly with newly created daughter cells directly embarking on their path to mitosis. Bacteria cells separate forming two cells after every thirty minutes under favorable conditions. However, the eukaryotic cells take quite longer compared to bacteria cells to develop and divide. Nevertheless, in both animals and plants, cell cycle is usually highly regulated to prevent imbalanced and excessive growth. Both animals and plants are known as eukaryotes meaning that their DNA exists inside their cells’ nuclei. Therefore, their cells as well as mitotic processes are similar in various ways (Eckardt, 2012).
..., while a cell undergoes cell cycle, when a cell comes in contact with another cell, it stops reproducing. However, cancer cells continue to duplicate repeatedly until there is a mass of cells or a tumor to form (see figure 9). Lastly, in cell division when there is a mutation or abnormality in the DNA, a normal cell stops dividing. However, a cancerous cell will continue to duplicate and form mutations (“Cell Biology and Cancer”). Also, cancer cells are harmful because they grow and duplicate with complete disregard to the functions and limitations of the body (see figure 10). Also, cancerous cells have the ability to spread through metastasis throughout parts of the body through the bloodstream. In terms of similar behavior to that of normal cells, cancerous cells also duplicate, but at a very different rate ("Cancer Cells vs. Normal Cells: What's Different?").
All organisms are made of cells that grow by cell division. An adult human being consists of about 100000 billion cells. Dying cells are replaced by a large number of unceasingly dividing cells. A cell duplicates its chromosomes, segregates the chromosomes, and divides into two. These ordered sequences of events are called a cell cycle. 2001 Nobel Prize in Physiology or Medicine to Hartwell, Hunt, Nurse and 1998 Lasker Prizes in Basic Medical Research to Hartwell, Masui, Nurse have made important discoveries about the regulation of a cell cycle. Understanding the regulation of a cell cycle is seminal to understanding why and how cancer cells are formed. In this review, I focus on how these crucial discoveries made progress in understanding cell cycle regulation and leading to understanding cancer cell and cancer therapy.
Healthy cells grow and divide in a way to keep your body functioning properly. But when a cell is damaged and becomes cancerous, cells continue to divide, even when new cells aren't...
Cell cycle is a complex mechanism that governs the cell growth and proliferation. Cell proliferation contributes to the continuity of life by producing cells, replenishing cells which undergone to cellular differentiation to acquired specialized phenotypes (function and morphology) to carry out living mechanism and towards the end-point-cell-death. Cell proliferation is determined by both extracellular signals such as cytokines and mitogen, and intrinsic cellular factors. Interactions of extracellular signals with intrinsic cellular factors trigger the biochemical events of cell proliferation. In the case of acquired immunity, proliferation is the important state after lymphocytes encountered to antigen presentation, and then leads to their effectors functions. Cell cycle regulators control the appropriate entry and progression throughout the cell cycle event. Thus, any cell cycle deregulation will potentially lead to tumourigenesis. (Malumbres and Carnero 2003)
The amount of DNA and organelles are doubled. Interphase is divided into three phases. The first stage is known as the growth stage, this follows cell division and is when cell organelles are synthesised. The second stage is known as the synthesis stage, this is when the DNA replicates. The finally the third stage is known as the 2nd Growth stage and this is when the centrioles replicate and energy stores increase.
The East Pennsboro elementary school raised money for a statue at a local park. The statue was a ring of children that were holding hands. There was one child missing; the link was broken. The statue was dedicated to East Pennsboro students that did not make it to their graduation. My sophomore year of high school inspired this piece of artwork.
Mitosis is the division of cells and when they grow uncontrollably, the cells become cancerous. The cells normally spend most of their time in interphase and only divide when they need to, like when the body grows or heals. If cells did not undergo mitosis in which they grow and divide, then we would not grow (Source D). Cells go through certain checkpoints to check if they are growing, and mutating DNA properly. Although, sometimes a cell fails a checkpoint and the
Cancer develops when cells in a part of the body begin to grow out of
Cancer is a disease that affects human somatic cells. It causes the cells to divide uncontrollably and form masses known as tumors. There are two different types of cancer tumors. Some tumors are benign and other tumors are malignant. Benign tumors look similar to the tissues that they came from and develop slowly. The tumor remains in the same area that the tumor originated in. Malignant tumors are formed from cells that do not resemble the tissue that they came from. They vary in shape and size. This enables pieces of the tumor to break off and spread to other places in the body. Over the past few decades cancer has become a very prominent disease. There are many different types of cancer and many different causes for the the disease. Most cancers are because of a genetic mutation. The most common type occur when a cell is dividing. Proto-oncogenes, which are alleles in a normal cells, mutate to form oncogenes. These oncogenes cause cancer because they do not allow the cells to self destruct or become epistatic. There have been several research projects which have been testing epistatis.
interphase is a phase of an cell. the cell spends and performs most of its activity in this phase. there are three stages in interphase called G1, S-phase, G2. G1 is when the cell make proteins that is used for DNA replication. S-phase is when the chromosomes are replicated. during this phase, the proteins and DNA become active. the cells are not visible under light microscope. G2 is when the cell begins to grow and produce new proteins.
Tumors are formed by the alteration of the body’s own cells. This can be caused by environmental factors such as radiation, like UV exposure, chemicals or viruses 1. These can disrupt genes that control growth and cause an increase in cell division and proliferation. Proto-oncogenes are those genes that control normal but essential cell processes that keep cell growth and death in check. Two important categories are apoptosis genes, which regulate cell death, and tumor suppressor genes, which decrease cell propagation 1 . If these genes were mutated to the point where they cannot produce a functioning protein, cell division would continue far past what it was supposed to and unhealthy cells would be allowed to live and continue to multiply. This is what creates a malignant tumor. Certain conditions in the body can also promote the growth of cancer cells. One of these is a deficiency of natural killer (NK) cells, which are able to kill cancer cells by creating a pore in the cell membrane with perforin and releasing granzymes into the cell. Low levels of perforin allow for tumor growth 1. Chronic inflammation can also ...
Biology is the study of life of living organisms, divided into specialized fields that cover the differences in them. In my collage I included a quick, easy and understandable diagram of the Cell Cycle. The Cell Cycle is a major part of biology in my standpoint since almost all of the human anatomy is made from cells. I covered the 4 phases of mitosis, which include: Prophase,Metaphase, Anaphase and Telophase. I will tell a little about each. Prophase is the first phase to mitosis. This is when the nucleolus disappears and the chromatids condense together. During the Metaphase the chromatids attach to the spindle fibers, in which they meet in the middle of the cell. The next stage is Anaphase, during this stage the chromosomes move away from
The cell cycle is an undeniably fundamental part in the journey of a cell. Without it there would be no cell reproduction or growth. Through the process of mitosis and also meiosis which will be shortly discussed about, it will come to be known exactly just how important it actually is.
What is the cell cycle? It’s the way we reproduce. A series of events lead up from the beginning that which gives them life to the splitting of cells, The separate steps make up this very important process. Without the division of cells, we simply would not be here today.