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Effectors on Helicobacter pylori
Research paper on helicobacter pylori
Research paper on helicobacter pylori
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Recommended: Effectors on Helicobacter pylori
Introduction
Helicobacter pylori infect the stomach. It is common in children. (Mayo clinic, 2015). This bacteria is a common cause of peptic ulcers. H. pylori may actually be present in more than half of the world’s population (Mayo clinic, 2015). Most people are unaware they have a H. pylori infection because they rarely get sick from it. If signs of a peptic ulcer are found, doctors will most likely test for an H. pyloric infection.
Most of the population will never have signs or symptoms of this infection, the reason why is unclear, but it is believed that some individuals may be born with a high resistance to the harmful effects of H. pylori (Mayo clinic, 2015). H. pylori were first discovered in the stomachs of patients with gastric
and stomach ulcers nearly twenty five years ago by Dr. Barry J. Marshall and Dr J. Robin Warren of Perth, Western Australia. (Helicobacter foundation, 2014). Helicobacter is a genus of bacteria formerly placed in the genus Campylobacter and including one (H.pylori) associated with gastritis and implicated as a causative agent of gastric and duodenal ulcers (Webster’s, 2006). Gastric and duodenal ulcers at one time were thought to be caused by spicy foods, stomach acid and stress. In 1982, this view was dramatically altered; Dr. Robin Warren swallowed a liquid culture of H.pylori hoping to prove this bacterium causes peptic ulcers. Within weeks he was diagnosed with self-induced gastritis. This proved his hypothesis to be correct. In 1989, the new bacterium formerly called Campylobacter pylori was officially given a new genus due to its ability to take on a helix shape, thus becoming what we know today as Helicobacter (Tenglish, 2013). Conclusion In Pakistan Helicobacter pylori is on the rise because of the inability to properly diagnose and treat this bacterium, because H.pylori is not being treated they fear it may become a chronic disease thus leading to a rise of stomach cancer (Qasim, 2012). "Bacterial virulence factors, host genetic factors, and environmental factors contribute to the risk for developing gastric cancer, and further studies are necessary.” Seiji Shiota is a medical researcher at Oita University in Japan and Yoshio Yamaoka is a medical pathogenesis, they have discussed the eradication of H. pylori. They warn that practitioners need to proceed with caution when treating with antibiotics as a widespread solution, "if all infected persons are to be treated, we should consider the increase in frequency of antibiotic resistance and unexpected consequences such as esophageal adenocarcinoma, asthma and autoimmune disease." (Infection control today, 2010).
In all the cases, some people were hospitalized. To treat the infection, people should rest and take antibiotics promptly. So as you can see, Salmonella typhimurium is a serious microorganism that can create a lot of havoc if it gets inside of a person’s system and although there are many ways to diagnose it, it must be diagnosed quickly or a person could end up in the hospital.
In the article, “An Endangered Species in the Stomach” by Martin J. Blaser, he talks about a 60,000 year old bacterium living in the human stomach, named “Helicobacter pylori”. H. pylori was first isolated for investigation in 1982 by Barry J. Marshall and J. Robin Warren. Later researchers discovered that H. pylori was responsible for developing peptic ulcers, breaks in the lining of the stomach, or could also cause stomach cancer. For the past 100 years, there has been decrease in H. pylori bacteria in humans due to the widespread use of antibiotics and improved hygiene. At the same time, the disappearance of H. pylori caused an unexpected rise in the acid reflux disease and a deadly type of esophageal cancer. Making H pylori a vital microorganism to research in order to expand the study of microbiology and its interaction with humans.
Diagnosis of salmonellosis involves testing a sample of stool, as well as isolation from samples of tissue, blood, or urine. Since it is commonly mistaken for the flu and involves similar symptoms to other illnesses, the method of diagnosis for salmonellosis is pretty hard to come by. Most people with salmonellosis don’t seek treatment, so they’re never aware that they even had it. Since it is a foodborne pathogen, has a common route of infection via oral ingestion, and is found in food products that we consume on a daily
The helicobacter pylori bacterium also commonly known as H. pylori is a spiral shaped bacterium that is often found growing in the digestive tract. H. pylori bacteria are found in more than half of the world’s population. The bacteria normally attack the lining of the stomach and the small intestines. Although they are present in many people the H. pylori bacteria is usually harmless. The bacteria are adapted to live and survive in the acidic environment of the digestive tract. Furthermore, H. pylori reduces the acidity of the environment around it to survive and will penetrate the lining of the stomach and small intestines where the mucus lining protects it from the body’s immune cells. H. pylori sometimes can interfere with the body’s immune response to ensure their survival and this causes stomach problems (Flemin & Alcamo, 2007).
Field EA, Allan RB. Review article: oral ulceration--aetiopathogenesis, clinical diagnosis and management in the gastrointestinal clinic. Aliment Pharmacol Ther. 2003;18:949–62. [PubMed]
In addition to its traditional clinical manifestations, GAS can also cause serious invasive disease such as necrotizing fasciitis, colloquially known as the flesh-eating disease. First broadly reported during the Civil War, when it was known as gangrene, necrotizing fasciitis occurs when an individual’s subcutaneous fat and superficial fascia become rapidly necrotic. Though incidence data is limited, one study estimated that, worldwide, there are approximately 660,000 cases of invasive GAS disease per year, with 97% of those cases occurring in low-income populations (4). Many microorganisms other than GAS have been linked with necrotizing fasciitis, including Staphyloccocus aureus, Escherichica coli, and Klebsiella pneumoniae, and the disease is often caused by a polymicrobial infection. However, the most well known causative agent in necrotizing fasciitis cases is usually Group A streptococci (6). Although risk factors for necrotizing fasciitis include diabetes, old age, and immunosuppression, nearly half of all infections occur i...
My disease is Streptococcal pneumonia or pneumonia is caused by the pathogen Streptococcus pneumoniae. Streptococcus pneumoniae is present in human’s normal flora, which normally doesn’t cause any problems or diseases. Sometimes though when the numbers get too low it can cause diseases or upper respiratory tract problems or infections (Todar, 2008-2012). Pneumonia caused by this pathogen has four stages. The first one is where the lungs fill with fluid. The second stage causes neutrophils and red blood cells to come to the area which are attracted by the pathogen. The third stage has the neutrophils stuffed into the alveoli in the lungs causing little bacteria to be left over. The fourth stage of this disease the remaining residue in the lungs are take out by the macrophages. Aside from these steps pneumonia follows, if the disease should persist further, it can get into the blood causing a systemic reaction resulting in the whole body being affected (Ballough). Some signs and symptoms of this disease are, “fever, malaise, cough, pleuritic chest pain, purulent or blood-tinged sputum” (Henry, 2013). Streptococcal pneumonia is spread through person-to-person contact through aerosol droplets affecting the respiratory tract causing it to get into the human body (Henry, 2013).
Legionnaires’ disease is an infectious disease caused most often by the bacteria Legionella pneumophila (L. pneumophila). The disease resembles severe pneumonia. Legionnaires’ disease is sometimes called “Legion Fever.” It was first discovered in 1976 when there was a pneumonia outbreak among people attending a convention of the American Legion in Philidelphia. In January of 1977 the bacteria was discovered as the causative agent of the outbreak. While outbreaks receive substantial media attention, thousands of people are exposed to the bacteria each year and never have any serious signs or symptoms of the disease. The elderly, immunocompromised and smokers are the most susceptible. Most outbreaks that do occur are in the summer when water temperatures naturally rise. Fatality rate of the disease ranges from 5 to 30 percent (The Mayo Clinic, 2008).
Alzheimer’s disease considered a risk factor because of impairment of mental status (Berman&Slon, 2012). Due to their mental status, patients are unaware of prevention of pressure ulcers, which makes them more vulnerable to pressure ulcers. However, the dryness of the skin also considers as risk factors for pressure ulcers. Diabetes mellitus is also a risk factor of pressure ulcers as people with diabetes have sensation lost (Scemons&Elston, 2009). Age is an important risk factor because pressure ulcers are more common among older people as a result of the skin becomes more sensitive and fragile (Bedsores, 2014). Moreover, low blood pressure adds to the risk factor of pressure ulcers, incontinence of urine or feces also considered risk factors. Prolonged surgery, anemia, higher body temperature, and vascular disease are all risk factors for pressure
Salmonella is one of the most common causes of food poisoning. It is a gram-negative, aerobic (oxygen requiring), rod-shaped bacterium that can infect humans, birds, reptiles, and other animals. It results in the swelling of the lining of the stomach and intestines. Salmonella food poisoning occurs worldwide, however it is most frequently reported in North America and Europe. In the United States, Salmonella is responsible for about 15% of all cases of food poisoning (Salmonella food poisoning).
Bacteria are one cause of infectious disease. Bacteria are a single-cell microorganism that is very common in our bodies. Less than one percent of bacteria will actually make us sick. Some of the more common infections caused by bacteria include strep throat, salmonella, and e-coli. Strep throat is common in children and causes a painful sore throat. Strep is usually treated with antibiotic medication. Salmonella is spread on food that is contaminated by human or animal...
Ulcerative colitis, or UC, is a chronic gastrointestinal disease that causes inflammation and ulcers in the lining of the large intestine. It causes ulcers in the colon and rectum. Ulcerative colitis is one of two forms of inflammatory bowel disease. In UC, the inflammation from the ulcers breaks down the lining of the colon and causes bleeding and discomfort in the abdomen.
Patients suffering from peptic ulcers experience upper abdominal pain, heart burns, sleep disturbance, hunger, empty feeling in stomach, unable to drink too much fluid, chest pain, nausea and weight loss. But lack of treatment may lead to internal bleeding; seen by patients vomiting blood and therefore may become fatal resulting in death.
Salmonella typhoid bacteria have over 100 strains in the world today. Most cause illness in humans, but only a few of those strains cause the illness Typhoid Fever (Pike, 2014). Typhoid is a bacterium that has been very devastating to the human race for centuries. Typhoid thrives in undeveloped countries and countries with high populations and poor sanitation procedures. But, it is still a relevant disease here in the United States because of its ease of spread once someone is infected (Pollack, 2003). Antibiotic treatment is usually successful when treating Typhoid Fever, but it still has the ability to cause death, even with treatment of advanced medicine and antibiotics. When one thinks of salmonella, they will most commonly think of a food borne illness (food poisoning symptoms) caused by eating raw or undercooked animal products such as undercooked chicken or pork. That is the effect of some strains of the bacteria, but not the one that causes typhoid fever (Pike, 2014).
Health Canada estimates that about two million Canadian suffers foodborne illness per year and CDC (Center for Disease Control) estimates approximately 76 million foodborne illness cases occur in the United States per year. However, many foodborne illness cases are unreported. Some of the most common bacteria and viruses that cause foodborne illness are Salmonella, Campylobacter, Escherichia coli O157:H7, and Hepatitis. In the following report, you will read some of the major foodborne illness outbreaks in Canada and United States.