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Mycobacteriology
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Recommended: Mycobacteriology
My interest in medicine began the first time I (intentionally) held lethal bacteria. Mycobacterium marinum causes incurable granulomas in zebrafish. To me, however, this microbe also represents a vital step in my career path. Prior to studying M. marinum, I captured phages without testing their therapeutic potential. M. marinum thus provides my first chance to treat a disease in vivo. Pathogenic bacteria initially intrigued me last year, when I created an award-winning analysis on phage-host specificity. Exploring antibiotic resistance inspired me to harness phages as antidotes to bacterial infections. I became curious about drug resistance in mycobacteria while annotating the genome of a phage that may infect M. tuberculosis. To that end, I aspire to develop novel treatments for infectious diseases throughout my academic and professional careers. My desire to become a biomedical scientist has empowered me to apply for the Wadsworth Center Research Experience for Undergraduates (REU) program. …show more content…
The Wadsworth Center scientists’ research parallels my interests and aspirations. Dr. Anil Ojha’s research is of particular interest to me, since I intend to understand, prevent, and reverse biofilm proliferation throughout my career. My experience in suppressing pathogenic mycobacteria with phages makes Dr. Ghosh and Dr. Gray’s research intriguing as well. My proficiency in utilizing computational and microbiological techniques in experimentation will enable me to create an insightful REU project. Indeed, the REU program provides the most conducive environment for facilitating my growth as a researcher of infectious
After I complete my undergraduate study, I would like to continue my education by joining MD/PhD program, and get the necessary training leading to the career as Medical Scientist. Being a doctor specialized in infectious diseases can give me in-depth knowledge and experience as well as understanding how the human body works, and the relationships between the diseases. In addition, I would like to be active doing research on infectious diseases, and antibiotic resistant bacteria. Recently Clostrodium difficile and Carbapenem-Resistant Enterobacteriaceae became imminent threat to our
our everyday lives bacteria is constantly surrounding us, some of the bacterium that we encounter are beneficial to us but then there are the ones that are severely detrimental to our health. The way that they effect a persons body can differ from person to person. Many of the “microscopic foes” are very resilient and have a very fast reproduction rate. Not only do they reproduce quickly they sometimes seem to outsmart our immune system and not allow our bodies to fight the infection making it almost impossible to stop them. One thing that a lot if people rely on is the assistance of prescription drugs to get them better but even the drugs are not being effective and we can’t stop the pathogens from invading our personal places such as work, home, school, or anywhere. Even though modern medicine is advancing the pathogens could still get the get the best of us. The scary thing is we never know when the next pandemic or epidemic is going to arise. All it needs is some ordinary microbe to swap genes with a deadly germ to produce a “super pathogen” and it could happen to anyone, anywhere, as it did to Jeannie Brown who is from “our neck of the woods”.
Bacterial resistance to antibiotics has presented many problems in our society, including an increased chance of fatality due to infections that could have otherwise been treated with success. Antibiotics are used to treat bacterial infections, but overexposure to these drugs give the bacteria more opportunities to mutate, forming resistant strains. Through natural selection, those few mutated bacteria are able to survive treatments of antibiotics and then pass on their genes to other bacterial cells through lateral gene transfer (Zhaxybayeva, 2011). Once resistance builds in one patient, it is possible for the strain to be transmitted to others through improper hygiene and failure to isolate patients in hospitals.
The resistance to many antibiotics is a well-known property of bacterial biofilms. Biofilms are dense...
It was a shock. The pediatric psychiatrist diagnosed me with a novel maladaptive behavior syndrome known as attention deficit disorder (ADD). My condition has notably hindered my ability to concentrate, organize, and execute both in the classroom and within social spheres. However, I have tried to meet the challenges posed by this mysterious syndrome through a number of approaches. Although they have been arduous, I have improved my control over the consequences of this disorder.
Others will escape from this protective mechanism to travel and settle down at alveoli (Porth, 2011). Local inflammatory reaction occurs and macrophages are cells that act as next line defense mechanism to fight with mycobacteria. First they engulf micobacteria, try to reduce their strength and ability, and kill them. In the same way they send antigen to helper T lymphocytes to initiate a cell-mediated immune response (Knechel, 2009). The infected macrophages will send produced cytokines and enzymes to breakdown mycobacteria’s protein.
Mycobacterium is a bacillus –a rod shaped, cord forming, bacteria. The reason the organism creates problems for its host is due to the fact that its cell wall contains large wax like lipids called mycolic acids. Mycolic acids are strong hydrophobic molecules that form a lipid...
My small and humble town did not afford me the opportunities to investigate the many questions I had. It was when I had received acceptance into UCLA, I knew I held a golden key. I saw my first laboratory here at UCLA and it was not long before I applied for the Biomedical Research Minor in an effort to dive headfirst and start working in one. Last year, I worked under Professor Utpal Banerjee in the Department of Molecular, Cell, and Developmental Biology studying and elucidating a novel immunity independent inflammatory...
My passion for research began during the senior year of college when I was awarded the Junior Research Fellowship (~20 out of 500 applicants) to train in Dr. Sriram’s laboratory at the National Center For Biological Sciences in Bangalore, India. During my summer internship, I trained in basic molecular and cell biology techniques to investigate the function of signaling pathways in mitochondrial dynamics. Apart from technical skills, I was exposed to seminars from top scientists in the world, which motivated me to apply for graduate school. To obtain a strong platform in RNA biology, I joined Dr. Peter Baumann’s laboratory at the Howard Hughes Medical Institute & Stowers Institute For Medical Research in 2009.
Biofilms are formed by a six step process. First is a reversible process, when an organic monolayer(made of polysaccharides or glycoproteins) absorbs to the surface, altering the chemical and physical properties of the surface. This makes the surface more conditioned and increase the chance that planktonic bacteria will attach. Secondly, also a reversible step, is when the free-floating or planktonic bacteria encounter the conditioned surface, and some attachment of the bacteria may occur. The third step is when the bacteria is left attached too long, then an irreversible attachment occurs. F...
This turn of events presents us with an alarming problem. Strains of bacteria that are resistant to all prescribed antibiotics are beginning to appear. As a result, diseases such as tuberculosis and penicillin-resistant gonorrhea are reemerging on a worldwide scale (1). Resistance first appears in a population of bacteria through conditions that favor its selection. When an antibiotic attacks a group of bacteria, cells that are highly susceptible to the medicine will die.
To excel in the field of Biology is not merely my dream, but my passion. I have started on this path of never-ending discovery and I want to master this science. It would not be unjustifying to state that the world is a better place today because of the advances in biological sciences. It truly promises to be an ever-advancing profession on this planet where better cures are required for freshly determined diseases on a day-to-day basis. Gene Technology and Biotechnology are a boon to this world. Putting microorganisms to use in the formation of insu...
Bacteria have recently been found to resist a thousand times their normal dose of antibiotics (Baym et al. 2016). This increasing resistance in bacteria has left scientists searching for a more potent replacement to antibiotics, paving the way to increasing research on phage therapy. However, because the therapeutic use of bacteriophages is a novel discovery, its effectiveness and safety need to be further researched. In this essay, I will explore the safety, the advantages, and the disadvantages of phage therapy.
The scientists I will be discussing in this essay are Robert Koch, Louis Pasteur, and Ross & Grassi. These scientists are important because of their major contributions to the field of science and have saved many lives from very infectious diseases. They provided explanations to previously unexplainable causes of people’s death by studying microorganisms. These scientists contributed to everyone’s knowledge of contamination, germs, and dangerous microorganisms.
“Pathogens are infectious agents, such as a bacterium, virus, fungus or parasite, that cause disease when they colonize a host organism” (Pathogens). Pathogens have plagued societies time and time again. In the past people never had a way to fight them. But now the research into these deadly pathogens has brought many cures and vaccines to societies to protect them against these pathogens. Although the research into these diseases is not just to find cures and vaccines anymore, companies and organizations have recently started researching into GOF pathogens or gain-of-function pathogens. These pathogens have been modified to be transmitted faster, transmitted easier, or to be more lethal. The process of researching and enhancing pathogens has