Azithromycin Essay

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Azithromycin is an antibiotic that targets gram-positive bacteria, and it inhibits growth by binding to the 50s ribosomal RNA to prevent protein synthesis. Through the Kirby-Bauer test, it was found that the gram-negative enteric bacteria were susceptible to Azithromycin. Azithromycin is a hydrophobic antibiotic, which means that the outer membrane of the enteric bacteria is capable of resisting the detrimental affects of Azithromycin (Vaara, 1993). The susceptibility of our isolate A bacteria may be due to a mutation that affects the outer membrane of the gram-negative bacteria; consequently, the antibiotic is able to penetrate the bacteria and bind to the ribosome. Mutant strains of the enteric bacteria Escherichia coli and Salmonella typhimurium that are unable to synthesize lipid A and lipopolysaccharide, components of the outer membrane, were found to be more susceptible to Azithromycin since the antibiotic was able to diffuse through the outer membrane (Vaara, 1993).
Penicillin G targets gram-positive and gram-negative, cocci bacteria and is expected to kill Isolate A by...

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