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Analysis of commercially synthesized aspirin
Observation of synthesis of aspirin
Observation of synthesis of aspirin
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Recommended: Analysis of commercially synthesized aspirin
Aspirin (C9H804)
Most people know Aspirin as a pill to take when they have a headache or some other ailment. There’s much more to Aspirin than most people know about. This report will explain the chemical properties of Aspirin as well as what the uses are, the history of the chemical, and the discovery of the molecule.
Aspirin is also known as Acetylsalicylic acid. It is composed of nine Carbon atoms, eight Hydrogen atoms, and four Oxygen atoms. There are many chemical properties to it. The melting point of aspirin is about one hundred and thirty-five degrees Celsius and the boiling point is one hundred and forty degrees Celsius. It has a density of 1.35 grams per milliliter and the molar mass is 180,160 g/mol (1). This means that the molecule is relatively dense. There is more weight than there is volume. Aspirin is described as odorless and colorless to where the color is white. It looks like a crystal-line powder at room temperature. It is a relatively stable molecule that should be stored at room temperature (2).
Aspirin is 3.3 g/L soluble in water (3). Aspirin can be soluble in ethanol, DMSO, or water (2). Aspirin has polar groups that when put with polar water molecules can form hydrogen bonds. Aspirin is an asymmetrical molecule. When drawing the Lewis Dot Structure, a person can see that the bonds are polar. There are also dipole moments making the molecule polar. Dipole molecules are composed of a higher electronegative atom pulling electrons towards it (11). It is more soluble in basic solutions than water and acidic solutions (4). The Lewis Structure also reveals that there are many double bonds between the carbons and two double bonds between oxygen and carbon.
Aspirin is most known as a pill to take to get rid of a ...
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Aspirin has grown so much in popularity that about 35,000 metric tons of it is produced and consumed each year to meet the consumer’s demand. 35,000 metric tons is equivalent to 100 billion standard aspirin tablets (10). That many tablets means that the market for aspirin is very good. Today, Aspirin is known as the leading non-prescription medicine of all time. It is the most common pill taken for pain, inflammation and fever. It has grown all over the world, being made available in eighty countries (9). It would not be surprising if one day, all the countries would have aspirin available to them.
Aspirin is much more than just a pill to take for aches, it has changed life for the better. It is used for medical purposes as well as everyday household needs. If people did not know about this simple yet life-changing molecule, the world would not be the same.
The purpose of this experiment was to learn and preform an acid-base extraction technique to separate organic compounds successfully and obtaining amounts of each component in the mixture. In this experiment, the separation will be done by separatory funnel preforming on two liquids that are immiscible from two layers when added together. The individual components of Phensuprin (Acetylsalicylic acid, Acetanilide, and Sucrose as a filler) was separated based upon their solubility and reactivity, and the amount of each component in the mixture was obtained. Also, the purity of each component will be determined by the melting point of the component.
The varieties of pharmaceutical and prescription drugs that are available to the public provide many different consequences, which could lead to other health problems among users. Opioids, for example, are typical...
In 2015, Doweiko’s research found that ”It is impossible for drugs to travel throughout the body without possible side effects“ (Doweiko, 2015, p.16). ”Prime affects versus side effects have been studied in order to find out how drugs harm but are contributing to healing“ (Doweiko, 2015, p. 16). The primary concern appears to be whether harm has to be the lesser concern in order to heal. Aspirin was used as an example of the healing component versus the side
Today, Johnson & Johnson is a pharmaceutical giant worth $71 billion. The company is listed on NYSE as JNJ with 2.83 billion shares outstanding with the value of $92.7 per share.
1-Butanol with intermediate polarity was soluble in both highly polar water and non polar hexane as 1-butanol can be either polar or non polar compound. 1-Butanol was polar based on the general rule of thumb stated that each polar group will allow up to 4 carbons to be soluble in water. Also, 1-butanol can be non polar due to their carbon chains, which are attracted to the non polarity of the hexane.
Doctors work under intense pressure, and if a pill could fix a patient’s problems than many saw nothing wrong with that. What exacerbated the problem was that many hospitals also changed their modus operandi with regards to treatment. In some hospitals, “doctors were told they could be sued if they did not treat pain aggressively, which meant with opiates (95). However once the patient became addicted and could no longer get their prescription legally refilled, the drug dealers saw their chance. What is surprising is the fact that pharmaceutical companies acted in the same manner as drug dealers. Both sides did not care about the end user, and the problems they would have to deal with after using what was given to them. Their motive was purely to profit as much as possible, and they did not care about who would get hurt as a result of their
Sam Surf had suspicions about the illegal knockoffs and inaccurate measurements of the active and inactive ingredients in San Diego drug store purchased Panacetin. The purpose of the experiment was to respond to the message from a drug watchdog agency, the Association for Safe Pharmaceuticals (ASP). The experiment was carried out in order to determine the percentage of aspirin, sucrose, and the unknown component by analyzing the drug preparation of “Panacetin,” and in the final stage, to identify the unknown component as acetanilide or phenacetin through purification. The purification of the unknown product was performed by boiling and allowing recrystallization of the product, then drying it to be further analyzed. The melting point ranges were measured in order to complete the analysis of the unknown product to determine its actual identity as either phenacetin or acetanilide.
In the business of drug production over the years, there have been astronomical gains in the technology of pharmaceutical drugs. More and more drugs are being made for diseases and viruses each day, and there are many more drugs still undergoing research and testing. These "miracle" drugs are expensive, however, and many Americans cannot afford these prices.
In the late 1800’s it was discovered that papa-amino-phenol, could reduce fever, but the drug was too toxic to use. A less toxic extract called phenacetin was later found to be just as effective but also had pain-relieving properties. In 1949, it was learned that phenacetin was metabolized into an active but also less toxic drug, acetaminophen. Since then, acetaminophen has been sold under many over the counter brand names, most popular being Tylenol.
The percentage of crude acetaminophen was 77.78%. The infrared spectrum of synthesised acetaminophen was similar to the USP grade acetaminophen. The functional groups and type of bonds in acetaminophen were identified. The NH bond stretching at wavenumber 3325.81 cm-1 and 3325.44 cm-1 in USP grade acetaminophen and synthesised acetaminophen. The bending of NH bond formed a band around 1610 cm-1. The presence of carbonyl group in both synthesised and USP grade acetaminophen gave a peak at wavenumber 1663.50 cm-1 and 1664.71 cm-1. Acetaminophen is para-disubstitution, it formed a peak around wavenumber 837cm-1. There were two small broad peaks found in both spectrum around wavenumber 3160 cm-1 to 3210 cm-1, this indicated the presence of OH group in the solutions. The melting point of synthesised and USP grade acetaminophen were 160 ℃-170 ℃ and 160 ℃-173 ℃. Both of these acetaminophen do not comply with the USP monograph melting point which is 168 ℃ to 172 ℃. This indicated there are some impurity presence in both of the synthesised and USP grade acetaminophen. The maximum wavelength of synthesised acetaminophen was 244.0 nm which was close to the wavelength of USP grade acetaminophen. The retention factor of synthesised and USP grade acetaminophen were 0.93 and 0.94. This showed that the purity of synthesised acetaminophen was similar to the USP grade acetaminophen. The absorbance value of synthesised and USP grade
Almost overnight one such venerable substance (or class of substances) has been catapulted into the national spotlight: prescription painkillers, namely those derived from the opium poppy. This class of analgesic encompasses everything from the codeine in prescription cough syrup to the morphine used in the management of sever pain. These compounds are commonly referred to as opiates and are produced naturally by the poppy. The sub-class of this type that has gotten all of the attention recently is the opioids, which are semi-synthetic compounds derived from the opiates (Wade 846). Opioids were developed for a variety of reasons, such as reducing the cost of production (morphine is expensive to synthesize) and attempting to reduce the addictiveness of the drugs.
Aspirin (acetylsalicylic acid) is a type of acid categorized as a salicylate, this acid works as a pain reliever in the body because once digested it lowers the amount of substances already in the body that cause pains, fevers and flare ups. Also, this chemical is administered to people for prevention of heart attacks, strokes, and angina which is also known as severe chest pains. Aspirin is created by chemically synthesizing salicylic acid through the acetylation with acetic anhydride, synthesizing aspirin comprises of three steps, synthesis of it, isolation and purification of it, and testing the purity of the aspirin made. Synthesizing aspirin is done by reacting salicylic acid and acetic anhydride with a catalyst, in which phosphoric acid (H3PO4) is used. After the aspirin has been prepared (synthesized), it must be isolated and purified. Aspirin is insoluble in cold water, therefore it can be isolated by filtering the cold solution product of the reaction. In order to remove the unreacted salicylic acid, acetic anhydride, acetic acid product and phosphoric acid the solution must be purified, the acetic anhydride is decomposed simply through the use of adding water after the reaction has finished (C4H602 + H20 2C2H402). Acetic acid and phosphoric acid can be removed from the solution by soaking the aspirin in cold water since they are soluble in water. The final ending step of purifying the aspirin is through a process referred to as recrystallization. This is when the aspirin is placed in warm ethanol, the solution is cooled, and the aspirin crystallizes leaving the salicylic acid and other impurities inside the solution. Lastly testing the purity of the finished product is achieved mainly from a melting point test a common...
Prescription drugs become America's new legal drug abuse problem. 1.) The U.S. Makes up 5% if the world's population, yet consumes more than 75% of the own world's prescription drugs, and more people thought that since it is pre-scripted by doctors, it won't be as harmful to take as much as they want a day. 2.) 50 Million people in the U.S. age of 12 and over, have used prescription drugs non-medically in their lifetime. 3.) According to pharmaceutical industries, it rakes about billions of dollars per year producing drugs to treat symptoms, like how the pharmacy, Big Pharma, raked $711 billion. This article is important because it talks about different people's experience with prescription drugs and how pharmacies are getting paid chunks
·Aspirin (salicylic acid acetate) is an anti-inflammatory (decreases swelling and inflammation), anti-pyretic (fever reducing), and anti-platelet (decreases platelets in the body to thin blood). Many heart treatment patients take an aspirin a day to prevent blood clotting. However, if aspirin is taken in large quantities over long periods of time, it may cause gastric ulcers or other internal damage. The molecular formula of aspirin is C9H8O4. Some examples of Aspirin are Bayer, Ecotrin, and Aspergum.
The synthesis of aspirin was remodeled and revised for a small scale experiment. An esterification reaction from the combination of salicylic acid and acetic anhydride with the presence of an acid catalyst produced acetylsalicylic acid (aspirin) and acetate. Purification of the crude aspirin was done through a technique called crystallization, wherein both the single solvent and mixed solvent