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Addiction changes the brain chemistry
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The effects of opioids essay
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Opiates And The Law
Illicit drug use and the debate surrounding the various legal options available to the government in an effort to curtail it is nothing new to America. Since the enactment of the Harrison Narcotic Act in 1914 (Erowid) the public has struggled with how to effectively deal with this phenomena, from catching individual users to deciding what to do with those who are convicted (DEA). Complicating the issue further is the ever-expanding list of substances available for abuse. Some are concocted in basements or bathtubs by drug addicts themselves, some in the labs of multinational pharmaceutical companies, and still others are just old compounds waiting for society to discover them.
Almost overnight one such venerable substance (or class of substances) has been catapulted into the national spotlight: prescription painkillers, namely those derived from the opium poppy. This class of analgesic encompasses everything from the codeine in prescription cough syrup to the morphine used in the management of sever pain. These compounds are commonly referred to as opiates and are produced naturally by the poppy. The sub-class of this type that has gotten all of the attention recently is the opioids, which are semi-synthetic compounds derived from the opiates (Wade 846). Opioids were developed for a variety of reasons, such as reducing the cost of production (morphine is expensive to synthesize) and attempting to reduce the addictiveness of the drugs.
And addictive they are. Heroin is perhaps the best-known opioid around, and arguably one of the most addictive substances known to man. Opiates and opioids (hereafter generically referred to as opioids) function by attaching to receptor sites in the body called mu-receptors, which are primarily located in the brain and the digestive system. When these receptors are activated in the brain they produce a rush of euphoria and a groggy state of well being (it is interesting to note that studies have shown that this action does not eliminate the pain one is feeling, but merely changes ones’ perception of it) (Kalb). The body quickly becomes tolerant of this, however, and abuse frequently follows a steep dosage curve requiring that more and more of the drug be taken to produce the same effect. Long-term abusers develop...
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...keep them from indulging their habit. The truth of the matter is no one change or modification to existing policy will have much effect if any, on the current state of affairs. It isn’t enough to ban drugs, we must work to understand their allure and the intricate mechanisms in our brains and in our psychology that make some of us too weak to resist the temptation. Only with this sort of concentrated effort will we see any progress.
Works Cited
Erowid Psychoactive Vaults. Home Page. 6 April 2001.
Almost one hundred years ago, prescription drugs like morphine were available at almost any general store. Women carried bottles of very addictive potent opiate based pain killers in their purse. Many individuals like Edgar Allen Poe died from such addictions. Since that time through various federal, state and local laws, drugs like morphine are now prescription drugs; however, this has not stopped the addiction to opiate based pain killers. Today’s society combats an ever increasing number of very deadly addictive drugs from designer drugs to narcotics to the less potent but equally destructive alcohol and marijuana. With all of these new and old drugs going in and out of vogue with addicts, it appears that the increase of misuse and abuse is founded greater in the prescription opiate based painkillers.
A “drug-free society” has never existed, and probably will never exist, regardless of the many drug laws in place. Over the past 100 years, the government has made numerous efforts to control access to certain drugs that are too dangerous or too likely to produce dependence. Many refer to the development of drug laws as a “war on drugs,” because of the vast growth of expenditures and wide range of drugs now controlled. The concept of a “war on drugs” reflects the perspective that some drugs are evil and war must be conducted against the substances
Granted, opioid based Pain killers like OxyContin have been invented and used for centuries. It was Hippocrates who first used opioids as a form of medicine. He used opium to stop the pain of internal illnesses, like "women’s diseases" (Blachford and Krapp). But as time went on chemists were able to actually separate and isolate more compounds from the opium plant, such as the chemical Thebaine, the main substance used to make Oxycodone (Meier 57). Oxycodone is the chemical in OxyContin that gives it the pain killing effects, it was developed in Germany circa 1916, and they labeled it under the name Eukodal (Blachford and Krapp). From there, the FDA first approved the use of Oxycodone in 1976 (Blachford and Krapp). Then In 1996 a drug manufacturer by the name of Purdue Frederick started the sale of Oxycodone under the brand name OxyContin, in order to sell the drug he opened a special unit known as Purdue Pharma (Meier 12). Following the release in 1996, it became highly sou...
In medical school/pharmacology school, medical professionals are taught to treat severe pain with opioids. However, opioids should be prescribed with the possibility of future dependency in mind. Physicians often struggle with whether they should prescribe opioids or seek alternative methodologies. This ethical impasse has led may medical professionals to prescribe opioids out of sympathy, without regard for the possibility of addiction (Clarke). As previously stated, a way to address this is use alternative methods so that physicians will become more acquainted to not not treating pain by means of opioid
The pain-killing and pleasurable effects of morphine, the narcotic drug derived from the opium poppy, is widely known. Endorphins are surprising similarity to morphine. It was termed “endorphin” from endogenous (meaning within) and morphine (morphine being a pain killer). It was wondered why morphine and other opiate drugs should produce such powerful effects on the nervous system. Thus, the discovery of endorphins followed the realization that certain regions of the brain bound opiate drugs with high affinity. Endorphins were discovered nearly on accident in the 1970s by scientists doing research on drug addiction. It was found that the brain produces its own set of neurochemicals far more powerful than morphine but share the same receptors.
The abuse of and addiction to opioids and the current epidemic in America. Opioids are a class of drugs which have been used since ancient times to reduce pain. Although opiates are derived from opium and opioids refer to synthetic drugs created to emulate opium, nowadays the term opioid is used for the entire family of drugs including natural, synthetic and semi-synthetic. Opium is an extract of the exudate derived from seedpods of the poppy plant, Papaver somniferum. The opium poppy is native to the Middle East and was cultivated in lower Mesopotamia.
We claim that we need to "set a good example," but the government's every effort to impress fear upon our youth, to stigmatize drugs and drug users, has failed to have any effect.... ... middle of paper ... ... Ideally, I would not have to persuade my readers with facts.
A few common opioid pain killers are called hydrocodone and oxycodone. They are chemically very similar to opiates derived directly from the opium poppy
There are many biological factors that are involved with the addicted brain. "The addicted brain is distinctly different from the nonaddicted brain, as manifested by changes in brain metabolic activity, receptor availability, gene expression, and responsiveness to environmental cues." (2) In the brain, there are many changes that take place when drugs enter a person's blood stream. The pathway in the brain that the drugs take is first to the ventral tegmentum to the nucleus accumbens, and the drugs also go to the limbic system and the orbitofrontal cortex, which is called the mesolimbic reward system. The activation of this reward system seems to be the common element in what hooks drug users on drugs (2).
Opioid overprescribing is becoming major epidemic in the united state. Epidemiologic data from 2012 National Survey on Drug use and health states that 12.5 million American reported opioids abuse (3). Medications such as prescribed opioids have the ability to generate physical and psychoactive effects, which can alter consciousness and the ability to feel pain. Almost all civilizations have individuals who choose to use these drugs and often become dependent on the substance they are using. It is important to recognize though that these drugs do create some harmful effects such as altering natural functioning areas of the brain. They also help aids acute and chronic pain. From a historical prescriptive, opioid prescription shows that opioids
Opiate pills are astonishingly easy to find. Disturbingly, prescription opiate abusers are more likely to eventually develop a heroin addiction than a non-opiate abuser, as heroin will offer a parallel high at an inexpensive fee. While opiate painkillers do vary in how powerful they are, opiates are numbing painkillers that weaken the central nervous system, slow down body functioning, and reduce physical and psychological pain. Although countless prescription opioid narcotics are used in the way they were intended for the extent prescribed without complications, certain people become addicted to the way in which the drugs make them
Opioids are one of the most common recreational drugs. Some of the most common opioids are heroin, codeine, oxycodone, fentanyl, methadone, and morphine. Their legal uses are for cancer related pain and their recreational use is to produce feelings of euphoria. Opioids produce feelings similar to heroin, which makes opioids a gateway drug to heroin because they are much cheaper. In 2016, 42,000 people lost their lives to opioids and an average of 210 million prescriptions for opioids are written yearly. Women are more likely to have chronic pain, which in turn, makes them more likely to become dependent on opioids. Although forty-nine states have a drug monitoring program, drugs still get into the wrong hands. Opioids have had a huge impact
The opioid crisis which is also known as opioid epidemic refers to the rapid increase in the use of non-presription and prescription opioids in the U.S. Opiates are analgesic drugs which include those that are naturally derived from opium, like heroinee, morphine, and opioids. Synthetic and semi-synthetic drugs such as Vicodin, Percocet, fentanyl, and OxyContin also fall under opioids.
Opioid usage has been prominent in the past couple of years, but studies from the National Drug and Alcohol Research Centre have become more impotent to inform about the increased addiction across the globe. The mortality rate in opioids are higher than other drugs due to its addictive properties, thus leading to overdose. Overdosing on opioids isn’t just common in adolescents as once thought, yet it is frequent in adults as well. This information will provide proper education for the purpose of hindering this epidemic.
An opioid is a recommended medicine from the medication opium, an engineered tranquilize, which influences the focal sensory system and essentially it is misused. At the point when an opioid is mishandled there are higher dangers to a man's wellbeing, so the opioid is portrayed to be opiate (McCoy, 2015). The power of opioid mishandle is unsafe and exorbitant to society, and it will