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Insulin research paper
A reflection on insulins
A reflection on insulins
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Introduction (20%)
-Information is used to make an insightful and convincing argument for the hypothesis
-Detailed and complete for specific treatment, measurable outcome, and context.
Introductory paragraph about the broad field of the research.
Each subsequent paragraph becomes more specific, so together they provide all the relevant background information that is needed to understand the hypothesis.
Finally, at the end of the section, you should state the scope of the experiment you performed and your hypothesis.
Glucose metabolism is primordial for the correct functioning of the body, an equilibrium in its levels could lead to diseases and ultimately death. Glucose is used as energy source for muscle contraction as its breakdown produce ATP (Chen et al., 2010). Blood glucose levels (BGL) are regulated by hormones produced in the pancreas; Insulin (Perelis et al., 2015) and Glucagon (Tirosh, 2014), which work together to maintain healthy levels in the body.
Insulin promote glucose uptake from the blood into muscle and fat to be converted into glycogen and used as energy reservoir. Insulin therefore, lowers BGL in its presence. Glucagon, in the other hand promote glycogen breakdown to ensure glucose release, that then will be used as ATP source to allow energy expenditure by the body (Chen et al., 2010).
Exercise post ingestion of a meal decrease glucose levels and block endogenous glucose production, as glucose is used as ATP source to allow muscle contraction. BGL decrease faster in individuals that experience exercise compared to individuals who don’t (Jeukendrup et al., 1999).
In the present experiment the effect of exercise on blood glucose levels after a meal will be investigated. It is expected that after the ...
... middle of paper ...
...l glucose metabolism among men and women in all age groups (Basu et al., 2006). Dietary habits may also play an important role in glucose homeostasis. A regular diet that is rich in protein could affect the secretion of insulin and glucagon, and could affect gluconeogenesis and blood glucose levels(Linn et al., 2000).
In conclusion, we have presented data that supports that exercise post-ingestion of a high glucose loaded meal decrease the blood glucose levels compared to the glucose levels of the individuals who rested as seen in figure 1. This could be basis for further research regarding glucose homeostasis. Future studies are need to elucidate the mechanism by which glucose is metabolized in recovery time and how insulin and glucagon hormones control this.
but augments its utilization during subsequent exercise. Journal of Applied Physiology, 99, 707-714.
We then took 1ml of the 1% solution from test tube 1 using the glucose pipette and added it to test tube 2, we then used the H2O pipette and added 9ml of H2O into test tube 2 creating 10ml of 0.1% solution
According WebMD 2014. Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes. Type 1 diabetes mellitus, type 2 diabetes mellitus and gestational diabetes. It is a hormonal disorder of the pancreas either decrease in insulin level also known as hypoinsulinism or increase in insulin level also known as hyperinsulinism. Lowered amounts, insufficient of, or ineffective use of insulin leads to the disorder of diabetes mellitus. It is common chronic disease requiring lifelong behavioral and lifestyle changes. According to Peakman (2012). The development of type 1 diabetes mellitus is a genetic and an autoimmune process that results in destruction of the beta cells of the pancreas, leading to absolute insulin deficiency. There is usually a pre-diabetic phase where autoimmunity has already developed but with no clinically apparent insulin dependency. Insulin autoantibodies can be detected in genetically predisposed individuals as early as 6-12 months of age. In persons genetically susceptible to type 1 diabetes, a triggering event, possibly a viral infection the leads to production of autoantibodies that kill the beta cells and results in decline and a lack of insulin secretion. According to Wherrett. It is caused by impaired insulin secretion and insulin resistance and has a gradual onset. Those with type 2 diabetes may eventually need insulin treatment. Gestational diabetes mellitus is glucose intolerance during pregnancy in a woman not previously diagnosed with diabetes, this may occur if placental hormones counteract insulin, causing insulin intolerance. Complications in diabetes mellitus includes: Hypoglycemia it is ca...
This happens either through the removal of carbohydrates or by substituting low glycemic index carbohydrates for higher ones. In doing this the higher level of insulin will be reduced, for example high blood cholesterol levels will go down. To test the insulin and glycemic levels the energy bars contain the study had 20 healthy adult participants. They were split into groups receiving 1 of 5 test meals; 1 being low carbohydrates, 2) moderate carbohydrates, 3) high carbohydrates, 4) white bread, and 5) chicken breast. Chicken breast was the negative control since it contains no carbohydrates, whereas white bread was the positive control.
The purpose of a homeostatic system is to maintain steady/stable internal environment at a set point. Glucose is used as a major energy source by most cells in the human body. Cells break down glucose in order to produce ATP (energy), to carry out their cellular processes. Blood glucose concentration is maintained between 3.9-5.6 mmol/L-1. The reason behind this range is due to the fact that people of different ages and genders require different amounts of glucose in their blood to carry out different metabolic processes. For example, a growing teenage boy would require a higher blood glucose concentration in comparison to a middle aged women. Blood glucose concentration must be maintained between this set point range because anything above or below this can cause severe problems. If blood glucose concentration becomes too low the tissues in the body that solely rely on glucose as an energy source are greatly affected, as they need a constant supply of glucose in order to function adequately. These
Our body obtains the energy by digesting the carbohydrates into glucose. Volumes of glucose are required by the body to create ATP. ATP is short for 'Adenosine Triphosphate ' and is an energy carrier. When we consume too many carbohydrates our body produces a lot of glucose and as a result blood glucose levels rise and sometimes they may rise over the normal range of blood glucose concentration. To bring it back within the healthy range, the homeostatic system of blood glucose regulation is used. The blood flows through the pancreas where the beta cells, receptors, detect the high blood glucose level. To counteract this stimuli beta cells alert the control centre, which are also the beta cells located in the islets of Langerhans in the pancreas. The secretion of insulin has to be done quickly but can only be carried out when insulin gene is switched on. Turning on the insulin gene switch can take 30 minutes to an hour therefore, the production of insulin by beta cells are done in advance and are packaged in vesicles right until blood glucose rises. Glucose comes into the beta cell to trigger the vesicle that contains the insulin to move towards the plasma membrane and fuse. This releases the insulin into the bloodstream where they are distributed throughout the body and only affect specific target cells. The receptor, a protein, on the target cell’s plasma membrane recognises and connects
9. Zaharieva, D. P., & Riddell, M. C. (2013). Caffeine and glucose homeostasis during rest and exercise in diabetes mellitus. Applied Physiology, Nutrition & Metabolism, 38(8), 813-822.
Insulin is a key player in the control of intermediary metabolism. It has profound effects
When the blood glucose is higher than the normal levels, this is known as diabetes disease. The body turns the food we eat into glucose or sugar and use it for energy. The insulin is a hormone created by the pancreas to help the glucose get into the cells. The sugar builds up in the blood because either the body doesn’t make enough insulin or can’t well use its own insulin (CDC, 2015). In the United States diabetes is known as the seventh leading cause of death. There are different types of diabetes. However, there are two main types of diabetes and these are; Diabetes type 1 and Diabetes type 2 (CDC, 2015).
Other hormones (glucagons, epinephrine, growth hormone, and cortisol) work to oppose the effects of insulin and are often referred to as counterregulatory hormones. These hormones work to increase blood glucose levels by stimulating glucose production and output by the liver and by decreasing the movement of glucose into the cells. Insulin and the these counterregulatory hormones provide a sustained but regulated release of glucose for energy during food intake and periods of fasting and usually maintain blood glucose levels within the normal range. An abnormal production of any or all of these hormones may be present in diabetes.
In order for the body to maintain homeostatic levels of energy, blood glucose regulation is essential. Glucose is one of the body’s principal fuels. It is an energy-rich monosaccharide sugar that is broken down in our cells to produce adenosine triphosphate. In the small intestine, glucose is absorbed into the blood and travels to the liver via the hepatic portal vein. The hepatocytes absorb much of the glucose and convert it into glycogen, an insoluble polymer of glucose. Glycogen, which is stored in the liver and skeletal muscles, can easily be reconverted into glucose when blood-glucose levels fall. All of the body’s cells need to make energy but most can use other fuels such as lipids. Neurons; however, rely almost exclusively on glucose for their energy. This is why the maintenance of blood-glucose levels is essential for the proper functioning of the nervous system.
...ll cause your blood sugars to lower (Mayo Clinic Staff). While working out you will notice that your blood sugar levels will be all over the place so its important to have things such as glucose pills just in case your levels drop too low. Exercise may not be the cure for diabetes but it could be the thing that prevents you from getting it.
The postabsorptive state is the period when the GI tract is empty and energy comes from the breakdpwn of our body’s reserves. The importance of the postabsorptive state is to maintain blood glucose levels. The brain fuels itself using glucose as its energy source. We can get glucose from stored glycogen, tissue proteins, and some from fats. The first available store of glucose is in the liver’s stores of glycogen. These stores can maintain blood sugar levels for around four hours. When the liver stores begin to get small, glycogenolysis begins to take place in skeletal muscles. The glucose in the skeletal muscles is converted to pyruvic acid, which enters the blood and is converted back to glucose by the liver and again reenters the blood.
Blood glucose levels are the measurement of glucose in an individual’s blood. This is important because glucose is the body’s main source of fuel and the brains only source of fuel. Without energy from glucose the cells would die. Glucose homeostasis is primarily controlled in the liver, muscle, and fat where it stored as glycogen. The pancreas is also a significant organ that deals with glucose. The pancreas helps regulate blood glucose levels. Alpha-islet and beta-islet pancreatic cells measure blood glucose levels and they also regulate hormone release. Alpha cells produce glucagon and beta cells produce insulin. The body releases insulin in response to elevated blood glucose levels to allow the glucose inside of cells and
The pancreas uses these two hormones in order to monitor blood glucose levels. After a meal, blood glucose usually rises. This is when insulin secretion will start (Nussey S, Whitehead S. “Endocrinology: An Integrated Approach”). Consequently, blood glucose decrease to the normal range. This is how insulin maintains blood levels when is high. However, when blood level falls below normal range, glucagon comes into play. Low blood glucose occurs usually when hungry and during exercise. This will then triggers glucagon secretion. When blood level falls, the body goes into imbalance. Hence is why in order to maintain homeostasis glucagon is crucial. The body will tell the pancreas to increase more glucose and the pancreas will secrete glucagon by taking glycogen from the liver to produce glucose. The glucose will produce energy and will make blood glucose concentration increase (Homeostasis of Insulin and Glucose, Abpischools.org). When the pancreas cannot maintain homeostasis, many problems will arise in the body. When the pancreas fails to produce insulin, type 1 and 2 diabetes can occur. For those with type 1 diabetes, insulin injections will be needed in order to regulate blood glucose level, otherwise, glucose levels will be out of control. For type 2 diabetes, they are not insulin dependent like type 1, however, the body does not create enough in the body. When blood glucose
The pancreas, in addition to its digestive process has two important hormones, Insulin and Glucagon which are important for the maintenance of blood glucose level at a narrow range. Not only glucose, but also they are important for protein and lipid metabolism. Glucagon is secreted by the alpha cells of the islet of Langerhans and Insulin is secreted by the beta cells of Langerhans. Both are secreted to portal vein. (8)