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Recommended: History of ebola essay
The Ebola virus originated in the depths of the Democratic Republic of the Congo along the Ebola River. Little else is known about its origin but researchers believe that it was first transmitted from a non-human primate or bat. The virus can be contracted several ways including direct contact and contact with infected blood or bodily fluid. It is easy as accidently touching infected saliva or changing a Band-Aid on an infected person. Symptoms of the virus can range greatly but fever, headache, diarrhea, vomiting, and unexplained hemorrhaging are some of the most common. The Ebola virus attacks the body through the immune system, eventually breaking down everything in its path starting with the immune cells. The virus could ultimately …show more content…
The Washington Post created a pictorial breakdown on how the virus runs its course throughout the body. It is summarized by the following paragraph. As the virus is transmitted from one human to another the virus starts its journey in the human body by attacking the immune cells that are located in the blood stream. These affected cells make their way to the liver, spleen, and lymph nodes. Then the affected cells move from these organs to other tissue and organs. Proteins are then released from the cells which cause inflammation. The inflammation begins to cause damage in the tissue that is lining the blood vessels. The damaged vessels then begin to leak. Microphages then release the proteins from the affected immune cells which starts causing blood to start clotting. These clots in the vessels block blood from getting to the organs. Red blood cells (RBCs) then begin to break down because they are moving in the vessels that are lined with clots. The spleen becomes overwhelmed with the broken vessels and the cells in the liver begin to be devastated. Then the blood starts to lose its clotting agent causing internal and external hemorrhaging characterized by blood flowing out of body orifices and into the body cavity. The adrenal glands begin to shut down and this is followed by dangerously low blood pressure and the ability to make the steroid hormone is diminished. Next the organs and the rest of the body begins to shut down simultaneously. Convulsions, caused by fluid that accumulates in the brain, could possible cause the spread of the virus to those in range of the projectile blood and bodily fluid if not properly protected. This could possibly result in death by hypotensive shock and/or multiple organ failure.
This virus is similar to Ebola, because it started in the same place. Lab workers in Germany, in 1967, contracted the new virus while working with African Green Monkeys, which had the virus. The virus is described as a hemorrhagic fever. It has a fatality rate up to 90% and spreads through human to human contact. The first symptoms can be as simple as a fever and a headache, then can progress to organ failure, and fatal internal bleeding.
This virus searches for a new vulnerable host in order to survive and carry the disease to the next victim. The critical aspect around the spread of a virus is how drastically the reproduction process occurs. Without being controlled, the contamination throughout any species causes the spread to take place in a toxic way, “On day one, there were two people. And then, four, and then, sixteen. In three months, it’s a billion.
It has not taken human to human transmission yet, that we know of. So far all cases of the virus result from people coming into close contact with bird blood or droppings. If the transmission of the virus does take human to human form, it could unleash a global pandemic. This is the first time in history that humans have been able to prepare themselves for an epidemic. The bird flu virus travels with migrating birds.
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
It began with infection mainly in the blood vessels of the human skin and mouth, resulting in different kinds of symptoms that turn into serious stages. It was spread by physical contact with human skin and mostly affected children and adults. This disease was so outrageous that it led to a vast number of deaths in New England colonies. Also, smallpox virus is transmitted through airborne infection from the oral, nasal mucus of the infected person. But mostly was spread from close contact or contaminated material of the infected person.
The HBV virus is transmitted through contact with contaminated blood or other body fluids such as serum, semen and salvia. The condition following the infection can either be classified as acute or chronic HBV.
Ebola Zaire, a type of strain of Ebola, attacks every organ and tissue in the human body except skeletal muscle and bone. Small blood clots begin to appear in the bloodstream. The blood then thickens and slows, and the clots fit together in a mosaic. The mosaic thickens and throws more clots and the clots drift through the bloodstream into the small capillaries, where they get stuck. This shuts off the blood supply to various parts of the body, causing dead spots to appear in the brain, liver, kidneys, lings, intestines, and all through the skin.
There are many symptoms such as: high fever, delirium, vomiting, muscle pain, bleeding from the lungs, mental confusion, being tired, weakness, and heavily sweating. When victims start to get these symptoms, it is most likely that they have the disease. After catching the disease people on average only survived for two to four more days. It was rare that the disease spread from person to person. Most cases it is when a human gets bit by an infected flea containing the disease. (The Black Death 245)
Human Immunodeficiency Virus (HIV) leads to the life threatening Acquired Immunodeficiency Syndrome (AIDS). HIV only lives in the blood and other bodily fluids. Concentrations of HIV are small in vomit, sweat, tears, and saliva and cannot be transmitted by those fluids. The main transmission is through fluids like semen, vaginal fluids, and rectal mucous during sexual contact, breast milk and amniotic fluid passing to children, and blood during transfusions and exposure. Beginning stages of HIV start with the acute infection. During the first 2 weeks to a month after exposure to the HIV infection, most infected individuals with display symptoms of a severe flu. The symptoms include fever, swollen glands, sore throat, rash, muscle and joint aches and pains, fatigue, and headache. The early period of infection is known as the “acute retroviral syndrome” (Stages, 2013). Once the virus is out of the acute stage it enters into the latency stage where it continues to replicate but no symptoms are shown. As the infection progresses and the immune system beco...
The virus attacks the lymph nodes and lungs. The buboes formed from the virus are usually formed in the groin or armpit depending on the closest lymph node. The plague is highly contagious, spread by speaking, coughing, and sneezing. There are two types of plague, the septimic and the pneumonic.
In 1976 the first two Ebola outbreaks were recorded. In Zaire and western Sudan five hundred and fifty people reported the horrible disease. Of the five hundred and fifty reported three hundred and forty innocent people died. Again in 1995 Ebola reportedly broke out in Zaire, this time infecting over two hundred and killing one hundred and sixty. (Bib4, Musilam, 1)
According to the World Health Organization (2014) “Ebola first took place in 1976 in 2 simultaneous outbreaks, one in Nzara, Sudan.., in Yambuku, Democratic Republic of Congo. [and the] latter occurred in a village near the Ebola River, from which the disease takes its name”. The disease has also started spreading through countries such as Guinea, Sierra Leone, and Liberia (which are West African countries). The United States of America had their first case of Ebola on September 30, 2014, when a man traveling back from Liberia was diagnosed with the disease in Dallas, Texas (CDC 2014). The man did not show symptoms until he reached the United States.
Human Immunodeficiency Virus, also known as HIV, is a virus that attacks the immune system. It invades our T cells and then makes more copies of itself. It then destroys them and our immune system can no longer fight of other infections or diseases, which can lead to AIDS. There are three major routes it is transferred by. The first route is sexual intercourse through the vaginal, rectal, or penile tissues. The second route is a direct injection with HIV-contaminated drugs, needles, syringes, blood or blood products. The third major route HIV can be transmitted is from an HIV-infected mother to the fetus in the uterus or even through breast-feeding. Once the virus is transmitted to someone else, it attaches immune system cell called a dendritic cell. These cells are located by the mouth, vagina, rectum, and penis. The cells then transport the virus from the where the infection is to the lymph nodes where it also infects other immune system cells. Once inside the cell, the virus turns RNA into DNA, and then makes its way to the cells nucleus. The HIV weakens the immune system. The infected HIV cells convert into the messenger RNA then it is transferred outside the nucleus and is used to make more HIV infected cells.
A person who is HIV-infected carries the virus in certain body fluids, including blood, semen, vaginal secretions, and breast milk. The virus can be transmitted only if such HIV-infected fluids enter the bloodstream of another person. This kind of direct entry can occur (1) through the linings of the vagina, rectum, mouth, and the opening at the tip of the penis; (2) through intravenous injection with a syringe; or (3) through a break in the skin, such as a cut or sore. Usually, HIV is transmitted through:
At the start of this step B lymphocytes have already become activated and are now beginning to flood the bloodstream with free floating antibodies. However, to destroy the virus the body needs to activate other white blood cells. White blood cell activation can happen a number of ways. Some white blood cells such as macrophages, phagocytes, and B lymphocytes can easily recognize invaders and become activated (Delves). However, killer and helper T cells cannot identify foreign cells unless they receive help from other cells. T cells are activated either by antigen-presenting cells, or from the chemical signals that come from other cells (Delves). This happens when the antigen-presenting cells, give the antigen fragments to T cells after they are broken down, or when free floating antibodies from the B lymphocytes attract the T cells to the virus’s colonizing site (Hendry, et al. 39). The activation of both killer and helper T cells, enables the body’s adaptive immunity response to reach full potential, resulting in the increase of the rate and intensity of the response (Hendry, et al. 40). With the immune system activated and working at its maximum potential, the body can now move on to the third and final step in this process, restraining and eliminating the