Acute Tacrolimus Toxicity Successfully Treated with Phenytoin
Tacrolimus is an integral part of immunosuppression following solid organ transplantation. We present a case of acute tacrolimus toxicity in a renal transplant recipient successfully treated with phenytoin.
A 55-year old male with history of end-stage renal disease due to tuberous sclerosis and polycystic kidney disease who had undergone a living related renal transplant 17 years ago was transferred to our facility for evaluation of acute kidney injury (AKI). The patient was admitted to a psychiatric facility for suicidal ideations and had recently been initiated on multiple psychotropic drugs including haloperidol, quetiapine, benztropine, hydroxyzine, citalopram and fluoxetine.
I support the diagnostic conclusions associated with Disco Di because the symptomatology matched the research regarding MDD and BPD. Gunderson (2011) found that 6% of the population are diagnosed with BPD and of that 75% are females. He further states that most of these patients receive treatment after a suicide attempt. To be diagnosed with BPD the patient needs to display a minimum of five symptoms (Gunderson, 2011). Seven symptoms that Disco Di experienced are consistent with the clinical diagnosis of BPD which in Disco Di’s case includes: impulsive behaviour around substance use and sex, recurrent suicidal behaviours, feeling of abandonment, identity disturb...
“Immune Response: MedlinePlus Medical Encyclopedia.” National Library of Medicine - National Institutes of Health. Web. 18 Dec. 2011. .
Mortaz Hejri, S., Faizi, M., & Babaeian, M. (2013). Zolpidem-induced suicide attempt: a case report. Daru: Journal Of Faculty Of Pharmacy, Tehran University Of Medical Sciences, 21(1), 77.
While this writer had some rudimentary knowledge of the impact serotonin had on the brain, "Why? The Neuroscience of Suicide" by Carol Ezzell piqued my curiosity on the role levels of serotonin and the process by which it is absorbed in the brain affect suicidal patients. This article was recently posted on the Neurology and Behavior website as supplemental reading for neurology and behavior's spring semester 2003 class. In this article the writer Carol Ezzell weaves her own personal experience with informative reporting of groundbreaking neuroscience research on suicide. Through further research I discovered various articles on a group of scientists from Columbia University doing research on the difference in people's brains whom have attempted suicide and or succeeded.
Although suicide or attempted suicide is legal in every state, assisting in a suicide is considered illegal in every state except Oregon. Additionally, the Code of Medical Ethics section 2.211 declares that physician assisted suicide is "fundamentally incompatible with the physician's role as healer, would be difficult or impossible to control, and would pose serious societal risks." There are too many risks associated with physician assisted suicide that managing such a factor would be impossible to control. Even the best medical professionals are human beings with the potential for error. An undiagnosed or untreated mental illness can add to a patients desire to die, which in the case of ph...
Waters, Rob. “Antidepressants May Cause Suicide and Violent Behavior in Children and Teenagers.” Treating the Mentally Ill. Ed. Kyla Stinnett, San Diego: Greenhaven Press, 2004. Web. 28 Jan. 2014
Simon G.E, Savarino J, Operkalski B, Wang P S, (2006), Suicide risk during antidepressant treatment. ,Am. J. Psychiatry.,163, pp 41-47.
The kidneys can be permanently damaged if you continuously take the drug over a long period of time. You can get all kinds of cancers such as heart, liver , kidney. 40 % increase !!There are no nutrient supplements known to protect against kidney damage, but some amino acids such as Taurine powder and lots of Vitamin E might help.
...ected over another because it has less chance of damaging a diseased liver, worsening a heart condition, or affecting a patient’s high blood pressure. For all the benefits that anti-psychotic drugs provide, clearly they are far from ideal. Some patients will show marked improvement with drugs, while others might be helped only a little, if at all. Ideally, drugs soon will be developed to treat successfully the whole range os schizophrenia symptoms. Roughly one third of schizophrenic patients make a complete recovery and have no further recurrence, one third have recurrent episodes of the illness, and one third deteriorate into chronic schizophrenia with severe disability (Kass, 206).
...t that could be because the patient doesn’t take the correct mandatory health percautions or the body rejects the transplant. Jonathoan Finger was a transplant patient, with his first transplanted kidney failing, “The fact he hadn’t taken care of the kidney he’d recieved less than two years earlier caused emotional pain,”(Storch 44). Jonathan learned the hard what you have to care for your body especially after organ donation. Because not everyone is given an second chance and it could mean your life.
One consequence of untreated mental illness could be suicide, often a constant struggle for people who battle with a mental health problem. According a study, “In 2004, the FDA looked at published and unpublished data trials of antidepressants that involved nearly 4,400 children and adolescents...four percent of those thought or tried suicide (“Mental Health Medications”). In otherwards antidepressant are usually prescribed to overcome depression however, for others it can increase the thoughts of suicide greatly. Suicide is number 10 for the leading cause of
American Heart Association. (2000). Clinical training in serious mental illness (DHHS Publication No. ADM 90-1679). Washington, DC: U.S. Government Printing Office
According to the National Institute of Mental Health, scientific evidence has shown that almost all people who take their own lives have a diagnosable mental or substance abuse disorder, and the majority have more than one disorder. In other words, the feelings that often lead to suicide are highly treatable. That’s why it is imperative that we better understand the symptoms of the disorders and the behaviors that often accompany thoughts of suicide. With more knowledge, we can often prevent the devastation of losing a loved one.
Treatment of suicidal tendencies at any age, involves reducing risk factors for those tendencies. Maris (2010) listed some common single predictors of suicide. Some of the ...
The regular instances of criminal activities which involves harming or killing someone else (Homicide) or killing oneself (Suicide) is a common occurrence which at many instances can be attributed to some sort of mental disorder. Not all patients having one or another form of mental disorder displays aggressiveness enough that can lead to homicide, or at the other end of spectrum is so overwhelmed with hopelessness that the patient eventually comes to end his/her life. But, there is evidences which indicate that there is increased probability of these occurrences among individuals suffering from a mental disorder.