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Case study of neuroblastoma
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Neuroblastoma is one of the third most common of childhood cancers. There are about six hundred and fifty cases a year in the United States or about six percent of childhood cancers. It often is diagnosed in infancy and rarely in children who have reached the age of ten. Neuroblastoma is an adrenal cancer that most often develops in the adrenal glands atop of the kidneys of a fetus or in infants. Neuroblastoma can also develop anywhere along the sympathetic nervous system chain from the neck to the pelvis. The sympathetic nervous system controls heartbeat, blood pressure and reactions to stress. However, these tumors can begin in any part of the body. The chest, neck, pelvis and spinal cord are other common places for them. Cancerous cells
Stage 1 neuroblastoma applies to children who have a tumor in only one place. Surgeons can remove all of it that they can see. Stage 2 neuroblastoma is divided into 2A and 2B. 2A applies to children who have a tumor in only one place. Surgeons cannot remove all of it that they can see. 2B applies to children who have a tumor in only one place and cancer cells in nearby lymph nodes. Doctors may or may not be able to remove all of the tumor.
Stage 3 neuroblastoma applies to children who have any one of these. A tumor that doctors cannot remove all the way. The tumor has spread to the other side of the body and maybe to nearby lymph nodes. A tumor that doctors cannot remove all the way and that is in the middle of the body. It has spread to both sides of the body (in lymph nodes or other structures). A tumor in one place on one side of the body. Cancer also is found in lymph nodes on the other side of the
Children with high-risk neuroblastoma may receive radiation therapy after chemotherapy and surgery, to prevent cancer from recurring. Radiation therapy primarily affects the area where it's aimed, but some healthy cells may be damaged by the radiation. What side effects your child experiences depends on where the radiation is directed and how much radiation is administered.
Children with high-risk neuroblastoma may receive a transplant using their own blood stem cells (autologous stem cell transplant). Before the stem cell transplant, your child undergoes a procedure that filters and collects stem cells from his or her blood. The stems cells are stored for later use. Then high doses of chemotherapy are used to kill any remaining cancer cells in your child's body. Your child's stem cells are then injected into your child's body, where they can form new, healthy blood cells.
Immunotherapy uses drugs that work by signaling your body's immune system to help fight cancer cells. Children with high-risk neuroblastoma may receive immunotherapy drugs that stimulate the immune system to kill the neuroblastoma
but they are often more aggressive in adults than children. In adults, tumors in the hypothalamus are more likely to be metastatic (resulting form the spread of cancer form another organ to the hypothalamus) than they are when they occur in children. Peter Heage, of Colorado, was diagnosed with a hypothalamic brain tumor. He said that he was having headaches too often,
Glioblastoma Multiforme (GMB) is the most common form of primary malignant brain tumor in adults. With the current standard therapy, median survival time hovers just over 12 months. This incurable disease is devastating with a median survival time of 6-8 months from time of recurrence (J10). The current standard of therapy at first diagnosis consists of surgery followed by radiotherapy with concommittant and adjuvant chemotherapy using the agent temozolamide (TMZ) (Multiple sources). In 2003, the United States Food and Drug administration approved the Gliadel Wafer (GW) for treatment of newly diagnosed GBM (C3). The monoclonal antibody Bevacizumab (BEV) was first used to treat recurrent GBM in 2005 and has a significant survival benefit for patients with grade IV glioma (E5). Many more promising avenues for new treatment have been and are currently being studied. Such areas include the use of antiepileptic drugs, using Convection-Enhanced Delivery of chemotherapeutic agents, and targeting specific molecular markers and pathways such as the epidermal growth factor receptor (EGFR), O6-methylguanine-DNA-methyltransferase (MGMT), and the PI3K/Akt/mTOR pathway.
As the healthcare field continues to grow and evolve at an accelerated rate, new and advanced technologies are sprouting up everyday and becoming increasingly commonplace. A technology that has garnered both positive and negative attention is transplanting stem cells. Hematopoietic stem cells refer to the body's blood forming blood cells (American Cancer Society, 2013). Here is some background information on these types of stem cells. These cells are young and immature.
There are two types of Malignant Brain Tumors: Primary, and Secondary (Metastatic). Primary Brain Tumors begin in the brain, or in nearby tissues such as the meninges, cranial nerves, pituitary gland, or pineal gland. A Primary Brain Tumor begins from a mutation in the DNA. Metastatic Brain Tumors are more common, and occur from having had cancer in another part of the body, which spread to the brain.
Stage IIB can also be detected in three ways. If there is a tumor between two and five centimeters present with small groups of breast cancer cells sizes varying between .2 millimeters and 2 millimeters found in the lymph nodes. The second way that IIB can be found is if there is a tumor of those same dimensions found, but this time present with cancer cells that have spread to two to three axillary lymph nodes or to lymph nodes near the breastbone. The last way can be described as a tumor larger than five centimeters but has not spread to the axillary lymph nodes.
Due to the brain being protected by the skull, brain tumors have very little room for growth “without pressing on other parts of the brain,” which may cause damage to the nervous system and be life threatening and life altering (Abrahams 120). Some of the possible symptoms to abnormal growths are headaches, intellectual impairment, loss of memory, impaired judgement, confusion, and personality and behavior changes, but on countless occasions the symptoms may go undetected by the carrier (Abrahams
According to SEER Statistics, 23,380 people are estimated to get a brain or nervous system cancer diagnosis. Out of those people, 14,320 people are estimated to die from their brain or nervous system cancer diagnosis (National Cancer Institute). Cancer is a type of dangerous tumor, or a buildup of extra cells that form a mass of tissue, that can be life threatening (National Cancer Institute). The term for a tumor that is cancerous is a malignat tumor, whereas a benign tumor does not contain cancer cells (National Cancer Institute). According to the National Cancer Institute, the causes of brain cancer are unknown, but risk factors include family history and excessive radiaton exposure. Although they are not always due to a brain tumor, comon symptoms include headaches, nausea, speech, hearing, vision, and mood changes, problems with balance and mamories, seizures, and numbness in arms and legs (National Cancer Institute). MRI and CT scans as well as surgical biposies (or the removal of part of the tumor to be examined) are used to diagnose brain cancer (National Cancer Institute). Different types of treatment options include radiation therapy, surgery to remove the tumor, and chemotherapy. According to Charles Davis, MD, PhD and Nitin Tandon, MD of WebMD.com, chemotherapy is “ the use of powerful drugs to kill tumor cells”. There are a few different types of chemotherapy, but all of which bring out the same kinds of side effects. Although the physical side effects of chemotherapy are commonly known, few people know of the emotional toll chemotherapy can take on a patient and his or her family as they go though this process.
Each stage is characterized by an A, B, or C letter, depending on the degree to which the symptoms present themselves. The differences in each stage are as follows: stage 1 is when the cancer is either found in one ovary or both, stage 2 the tumor is found in one or both ovaries and extends to other pelvic structures, stage 3 the cancer has spread beyond the pelvis to the lining of the abdomen or to the lymph nodes and finally in stage 4 the cancer has spread to other organs in the body including the liver or lungs (Ovarian Cancer National Alliance). Cancer is “staged” by taking a sample of the infected tissue surgically and sending it to a lab for examination. Staging is crucial in order for medical professionals to determine which course of treatment would be the most effective for the given patient. If misdiagnosed, an entire area affected by this disease could potentially be missed and left untreated.
Cancer is a deadly disease that affects millions of American families each year. In cancer, cell division isn't controlled. Usually, cells have to go through a set of checks and balances before they divide, in cancer that is nonexistent. The cells just keep duplicating until they eventually form disorganized clumps called tumors. Tumors can either be, benign, meaning that they do not possess the power to metastasize to surrounding areas. If a tumor has the power to metastasize, it is classified as a malignant tumor. In simple terms, a benign tumor is not cancerous, and a malignant tumor is. Cancer cells cannot perform the necessary functions they were created for. Some types of cancers, like pancreatic cancer, cannot be cured. Other cancers such as melanoma and breast cancer have high survival rates when caught early. The four major types of treatments used to treat cancer include, surgery to remove the affected organ, radiation, chemotherapy, or biological treatments.
Steen, Grant R. and Joseph Mirro. Childhood Cancer: A Handbook From St.Jude Children's Research Hospital . Cambridge, MA: Perseus Publisher, 2000.
Neurofibromatosis type 2 (NF2) is a disease in which benign tumors develop and grow on various types of nerves along the central nervous system. It is caused by a mutation in the gene neurofibromonin-2. This gene typically acts as a tumor suppressor; a mutation in this gene causes failed suppression of tumors, resulting in the uncontrolled cell division that leads to the formation of tumors. These tumors develop and grow on various nerves along the central nervous system, directly affecting the nerves’ functions and therefore affecting an individual, specifically in the central nervous system. For instance, one vestibular schwannomas are a type of tumor which develop as a result of this disease. They grow on and affect
Kids are meant to be happy, play outside, go to school, and have fun. They aren’t meant to sit in hospitals, losing weight by the pound, carrying around IV poles filled with poison. It’s ridiculous and immature that we don’t have a cure for childhood cancer. The only “treatment” that we have is chemotherapy- a chemical that seems to help fight off cancer. Chemo doesn’t just fight off cancer cells though- it fights off healthy cells in your blood, mouth, digestive system, and hair follicles. The most frustrating thing about childhood cancer is that only 4% of federal funding is exclusively dedicated to childhood cancer research. It is true that more adults get diagnosed with cancer than kids, but does that mean that adults are 96% more important than children? The average age of diagnosis for an adult with cancer is age 67, and the average number of years lost is 15. 15 years are definitely many years, but not that many compared to the average number of years lost for a child- 71. Also, age 67 is a lot older than the average age of diagnoses for a child- age 6. At least the adults get to grow up and have the ability to even have cancer- some of these kids can’t even get through a fifth of their lives.
...urgery, and radiation therapy. Due to the fact that acoustic neuromas grow slowly, immediate treatment may not be necessary so Doctors will monitor the tumor with periodic MRIs and suggest other treatment if the tumor enlarges. Surgery may involve all or part of the tumor. There are three main surgical approaches translabyrinthine, retrosigmoid/sub-occipital, and Middle fossa. There is also a new technique called endoscopic resection which enables surgeons to remove acoustic neuromas using a small camera inserted through a hole in the skull. There are two types of radiation therapy: the first is Single fraction stereotactic radiosurgery (SRS) and Multi-session fractionated stereotactic radiotherapy (FRS), Selecting the right treatment depends on the size of the tumor, whether the tumor is growing. age. other medical conditions you may have and severity of symptoms.
( ). Around three thousand new cases of childhood ALL are reported yearly in the United States (Kanwar, 2013). Out of those diagnosed, white children seemed more often affected than children of other races and males were slightly more affected than females (Kanwar, 2013). The frequency of childhood ALL cases crest at ages 2 to 5 and then decreases as they grow older (Kanwar, 2013). Unfortunately, there are no identifiable causes associated with this cancer.
How does one see the symptoms for childhood cancer? First one must know that there are many different types. There are forty different types of children’s cancer, including: Leukemia, Lymphoma, Sarcomas, cancers of the nervous system, liver cancers, kidney cancer, and more. Out of these cancers, the two most common childhood cancers are Leukemia, and brain tumors. What is leukemia? It is a cancer in which the bone marrow and other organs that produce blood produce and increased amount of immature or abnormal white blood cells. The symptoms of leukemia are paleness, excessive bruising, pain in the joints, and fatigue. Brain tumors are formed when a massive amount of cells are produced on the brain. The symptoms for this are frequent headaches, vomiting, seizures, decreased coordination, weakness, and problems concerning vision.