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Soft bones resulting from a deficiency of vitamin d in adulthood is known as
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Rickets Disease
Rickets is a bone disorder found in children that causes the bones to soften and weaken before the fusion of the growth plate. The adult version of this disease is called osteomalacia. In both adults and children it is caused by a long term and extreme vitamin D deficiency. Vitamin D allows for calcium and phosphorous to be absorbed from the gastrointestinal tract which is necessary for bones to have their mechanical properties. In children Rickets can result in bone pain, slow growth, increase risk of fractures and bone deformities, such as scoliosis, bowed legs, and thickening of the ankles, wrists, and knees.
The main cause of Rickets is lack of vitamin D resulting from the child not getting enough or not being able to absorb it properly. Two main sources of vitamin D are from the sun and food. The ultraviolet light from the sun interacts with the skin cells and synthesizes vitamin D. The populations of children most at risk for developing Rickets from lack of sun exposure are children with dark skin because their
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These children can experience pain in their bones that makes them reluctant to walk, fatigue easily, and waddle as they walk. Skeletal deformities are also common such as thickening of the ankles, wrists, and knees, bowed legs, soft skull bones, and scoliosis. Weak teeth are also common that are prone to cavities and are delayed in coming in. Another common symptom of Rickets is fragile bones that are prone to fractures and delayed bone growth and development. The lack of vitamin D also can cause low calcium levels in the blood that can result in muscle cramps, twitching, and tingling in the extremities. Rickets is diagnosed by a physical exam where the doctor gently presses on the bones checking for these abnormalities. X-rays can also be done to check for deformities and urine and blood tests can be performed to confirm the diagnosis and monitor
In order to study the gene mutation that is supposed to cause Paget’s Bone Disease researchers had to have viable candidates to host the gene mutation. They found the best candidate to host the gene mutation in mice so they implanted the gene mutation in embryos of mice offspring. The researchers hypothesized that p62P394L is sufficient to induce PDB, especially since the p62 gene is responsible for encoding 62 kDa protein which functions in signaling osteoclast precursors. Results were found by fixing the first through fifth lumbar vertebra of four, eight, and twelve month old homozygote, heterozygote and WT littermates in 10% buffered formalin for 24- 48 hours. The first through fourth vertebra were then completely decalcified while the fifth was not. Longitudinal sections of both decalcified and undecalcified vertebra were cut, mounted on glass slides and stained to analyze. The mice with p62P394L had histologically normal bones, indicating that p62 mutation is not enough to induce Paget’s disease of the bone in vivo, there are additional factors necessary. Knowing osteitis deformas is due to hyper responsive multinucleated osteoclasts, it seemed a sensible suggestion. However, there are many other variables that should be factored when considering possible causes for osteoclast hyperformation. If p62P349L is present, doesn’t necessarily mean a person will get PDB, though an environmental factor such as measles could easily open up transduction pathways that could eventually lead to pagetic bone lesions. We find this study to be a stepping stone for future researchers to use in order to actually identify what causes Paget’s bone disease. (Hiruma, Kurihara, Subler, Zhou, Boykin, Zhang, Ishizuka, Dempster, Roodman & Wi...
Osteogenesis Imperfecta (OI), also called fragile bone ailment or Lobstein disorder, is an inherent bone issue portrayed by weak bones that are inclined to break effortlessly with practically zero cause. A arrangement of various sorts of OI is regularly used to depict how seriously a man with OI is affected.OI is brought on by hereditary deformities that influence the body's capacity to make solid bones. In predominant established OI, a man has too little sort I collagen or a low quality of sort I collagen because of a transformation in one of the sort I collagen qualities which makes the bones
Physiological Basis of disease: DMD is the commonest and most serious form of the dystrophies. The gene responsible for dystrophin which, when absent, causes DMD. Amount of dystrophin correlates with the severity of the disease (i.e., the less dystrophin present, the more severe the phenotype). Since the gene is on the X chromosome, it primarily affects males, and females who are carriers have milder symptoms ( www.nlm.nih.gov/medlineplus/ency/article/000705.htm).
But after the early stage, your bones may become weak. These signs include: back pain, shortness of breath, shrinkage in height and bad, irregular posture. Many people don’t start showing signs until they have broken a bone, such as a wrist bone or a hip bone. There are two different types of Osteoporosis. There is Juvenile Osteoporosis (which is very rare), it occurs in children that is due to medication or medical conditions. Premenopausal Osteoporosis which happens to older women before menopause. There are three different ways to check for Osteoporosis. The first one is a painless bone density scan called a dual energy X-ray absorptiometry (DXA) (Stang, 2016). The second one is a digital x-ray radiogrammetry (DXR), it is like the DXA but uses less technology. And the last one is ultrasounds. Ultrasound scans are also used to screen for osteoporosis but it is not able to get a good reading like the others, so this method isn’t used as often. If you break a bone the doctor will try these types of x-ray to see if it was caused by
These include diseases such as rickets which is caused by a lack of vitamin D. A lack of calcium leads to poor growth in children. At this tender life stage this is a very negative thing because children are still at the peak of their physical development. The malnutrition could have caused stunting which is because the malnutrition hinders growth in their height and weight. Sometimes stunted growth can be permanent and a child may never be able to return to a normal height or weight.
Muscular Dystrophy is a genetic disorder in which your muscles drastically weaken over time. Muscles are replaced with “connective tissue,” which is more of a fatty tissue than a muscular one. The connective tissue is the tissue that is commonly found in scars, and that same tissue is incapable of movement. Although Muscular Dystrophy affects muscles in general, other types affect certain groups of muscles, and happen at different periods throughout a lifetime. For example one of the most common types, Duchenne Muscular Dystrophy, targets muscles in the upper thigh and pelvis. The disease is displayed throughout early childhood, usually between ages four and seven. This genetic disorder occurs only in boys. People have difficulty sitting up or standing and lose their ability to walk in their early teens. Sadly most people die by the age of twenty. A second common type, Becker’s Muscular Dystrophy affects the same muscles as Duchenne, but first appears in teenage years. Most people with Becker’s only live into their forties (Fallon 1824-1825).
The symptoms of Duchenne Muscular Dystrophy begin to show at a very young age; usually becoming noticeable around the age of three. The child may seem to have slow motor skills, have difficulty climbing stairs, and their calves may harden and begin to enlarge. Children will often walk on their tip toes as their leg muscles tighten and have difficulty jumping. The affected child may arch the back and stick their stomach forward in an attempt to balance themselves while walking. These changes in the body will become more noticeable throughout the ages of four a...
Osteopenia can be seen as beginning stage of osteoporosis. Osteopenia is classified when bone density is lower than normal but not so low that it can be classified as being osteoporosis. It can be caused by several different diseases, conditions, or may be something that is natural to the person who has it. It can also be caused by eating disorders, and metabolism disorders. Chemotherapy and medicines such as steroids are also known to be causes as well as being exposed to radiation.
Osteogenesis imperfecta (OI), also known as brittle bone disease, is a rare genetic disorder with the main characteristic being that the bones break very easily, usually for no apparent reason. The major cause of osteogenesis imperfecta is a mutation in the genes that produce collagen. Collagen is the main protein that works toward the production of connective tissue. Individuals with this disorder will produce less collagen than needed, which causes the bone development to be endangered. This could result in bone deformities. There are four types of osteogenesis imperfecta, and in all four types you will see bone fragility with multiple fractures and bone deformities.
The syndrome is caused because of Genetic mutation that replaces connective tissues (muscles) with bones when someone gets injured instead of getting cured. This results in a new skeletal structure. Unfortunately this syndrome does not have any cure and the patients are advised to always be careful and not to fall or have any kind of traumas. They can’t engage in any sports in order to prevent any injuries. Surgery for removal of extra bones is not an option because removal of bones will lead to ingrowth of more bones. From previous cases it is seen that most of the patients suffering from this condition do not live more than 40 years and they die of respiratory
The big picture. Where the two schools of medicine differ is in philosophy. Doctors of osteopathy "treat people, not just symptoms," says Karen Nichols, dean of the Chicago College of Osteopathic Medicine. "The course list looks exactly the same, but the M.D.'s focus is on discrete organs. The osteopathic focus is that all of those pieces are interrelated. You can't affect one with out affecting another." That means paying more than simple lip service to the idea of the "whole" patient: It means that diagnosis and treatment rely on an examination of a person's environment and family and general situation as well as his or her body. Not surprisingly, about 65 percent of the nation's 52,000 licensed osteopaths (by comparison, the country boasts at least 900,000 M.D.'s) are primary-care physicians. The American Association of Colleges of Osteopathic Medicine has a description of osteopathic training, as well as short profiles of 20 schools, at www.aacom.org. The D.O. programs and their contact information are listed in the directory section of this book.
Other metabolic bone diseases are osteoporosis, gout, OSTEOARTHRITIS, and PAGET'S DISEASE. Nutritional Disorders Nutritional deficiencies that result in bone damage include RICKETS in children and osteomalacia in adults, caused by a lack of vitamin D. In children, calcium and phosphate are poorly distributed on bones during development, resulting especially in deformity of the legs and arms. In adults, bones of the spine, pelvis, and legs become demineralized and the bones weaken.
Obvious signs include crooked spine while bending over, fatigue, shortness of breath, uneven hemline on shirts, and an asymmetrical waistline. Less obvious signs must be detected by health professionals through early screening, or diagnosed by your physician during a comprehensive physical exam.
Rickets is a disease that occurs in children aged 0-36 months as a result of a serious Vitamin D deficiency, with the majority of the children diagnosed between the age of three and 18 months. This deficiency leads to poor calcium mineralisation and deformation of the skeletal system such as the legs, ribs, wrists and skull. This disease is most commonly found in children from developing countries such as Africa, India and the Middle East, as well as cultures who are not regularly exposed to sunlight.
If the spine is normal then the issue is part of the child growing or a different issue that is causing enough pain to warent a trip to the doctors. If the angle is off however then it will be diagnosed as Scoliosis, Lordosis or Kyphosis respectively.