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An assay on rabies virus
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ETIOLOGY " Rabies is a bullet shaped Lyssavirus (lyssa meaning frenzy)1 " Rabies is from the family Rhabdovirus.2 " The rabies variant is named after the reservoir host. For example, rabies from a bat is called bat rabies, and rabies from a canine would be referred to as canine rabies2 " Viruses may contain either DNA or RNA and utilize live cells to reproduce.1 " The Rabies virus contains RNA. The Rabies virus also mutates abruptly creating mutant strains of the virus.1 " When the virus enters the host, it is initially in numbers far too miniscule to trigger an immune response.1 " The virus remains in the tissue for a while after being introduced into the body. As soon as their numbers increase enough, the virus travels throughout the body …show more content…
1 " An animal with furious rabies exhibits the classic signs of becoming vicious. The animal is restless and will bite anything in its path. o The other form is "furious" rabies (also known as classic rabies).1 " If an animal has the paralytic form of rabies it appears unaware of its surroundings and remains quiet, but they may bite if handled. 1 " Foaming at the mouth and drooling may be present with both forms of the disease.1 " Other clinical signs include:1 o Seizures1 o Paralysis1 o Inability to swallow1 o Nervousness1 " All of these symptoms occur because the virus is basically damaging the animal's nervous system. Paralysis is due to peripheral nerve and spinal cord damage. When the virus reaches the brain, behavioral changes develop due to brain damage and fatal
Rabies is a deadly virus that occurs in the brain. It can affect all mammals but the ones that are most commonly found with the virus are dogs, bats, raccoons, skunks, and coyotes. This means that any non-mammal can not contract the virus, such as fish, birds, and reptiles (2). The virus can be contracted by humans with saliva transfer with broken skin contact from an animal which has the disease. As this is the most common form of transferring the disease it is very believable that Tea Cake contracts the virus from the wild dog that “managed to bite [him] high up on his cheek bone once” (1). The rabies virus works by being a bullet shaped virus that directly attacks th...
Almost 2,000 died the night of the 1928 storm in Florida. Their Eyes Were Watching God by Zora Neale Hurston realistically depicts the Okeechobee hurricane that struck the coast of South Florida. The incredulous, category four storm produced winds as high as 150 mph and flood waters of up to eight feet. Hurston describes their heart wrenching experience throughout the end of the novel when Janie, the protagonist of the story, survives the devastating hurricane with her husband, Tea Cake. The book shows similarities between the overflow of Lake Okeechobee and the specific weather conditions of the hurricane, but differs regarding the aftermath of the storm.
First, it is extremely important that you seek medical attention immediately. As a result of the dog bite, you are susceptible to deadly diseases and serious infection. Second, you should consider seeing a counselor. Being bitten by a dog is a traumatic experience. Often, as a direct result of the trauma of being bitten, a victim might have an irrational fear of animals, suffer from nightmares, or experience other symptoms associated with psychological trauma of being bitten by a dog.
Kopp, Elizabeth, and Medzhitov, Ruslan. “A Plague on Host Defense.” The Journal of Experimental Medicine. .
Rabies virus belongs to Lyssavirus genus, Rhadboviridae family. It is a negative-sense, non-segmented, single-strand RNA and 180 nm long* 75 nm wide bullet-shape virus. All rhabdoviruses have two main structural components: a helical ribonucleoprotein (RNP) complex and a surrounding viral envelope. The rabies virus genome encodes five functional proteins: L (transcriptase), N (nucleoprotein), and NS (transcriptase-associated) protein with viral RNA are composed of the RNP complex. This complex adds up in the cytoplasm of neurons that are infected by rabies virus and makes up Negri body that is an indicator of rabies for histopathologists. Another two proteins are M (matrix) and G (glycoprotein) proteins that are associated with the lipid envelope. The G protein shapes the protrusions that are spikes-shape surface antigen on the virion envelope and induce virus-neutralizing antibody.
Another targeted areas of a cow with mad-cow disease is the spinal cord. The prions will also cause deterioration of the spinal cord. This is what cause paralyzation in some infected cows. The destruction of the spinal cord causes paralyzation because the prions deteriorate some of the nerves necessary for movement and feeling. Also, the spinal cord is linked so if prions devour one of those links, it would be similar to breaking the animal’s back.
The virus is primarily spherical shaped and roughly 200nm in size, surrounded by a host-cell derived membrane. Its genome is minus-sense single-stranded RNA 16-18 kb in length. It contains matrix protein inside the envelope, hemagglutinin and neuraminidase, fusion protein, nucleocapsid protein, and L and P proteins to form the RNA polymerase. The host-cell receptors on the outside are hemagglutinin and neuraminidase. The virus is allowed to enter the cell when the hemagglutinin/ neuraminidase glycoproteins fuse with the sialic acid on the surface of the host cell, and the capsid enters the cytoplasm. The infected cells express the fusion protein from the virus, and this links the host cells together to create syncitia.
Rabies does not discriminate against any warm blooded mammal; all that come into contact with the virus are at risk. Those who choose to live, work, and recreation in areas with a larger wildlife population are understandably at higher risk. People should be extremely wary of unknown animals and heed behavior changes in familiar animals. The virus is usually spread from a bite wound when the saliva of an infected animal is introduced to the victim via the bite. The virus travels from the origin of the wound to nerves and onward to ultimately infect the brain.
however, inoculations of mice with the patient's serum resulted in the isolation of a virus
Do bats carry disease or rabies? Yes, there is many diseases they carry. A few of the disease rabies, nipha, hendra, ebola, and marburg are all viruses that bat carries and cause serious diseases in humans. Rabies is a disease that is spread through saliva or tissues from the nervous system. 90% of deaths are disease in the world.
A “vaccine” or otherwise known as a vaccination, is something that stimulates someone’s immune system from a disease. Vaccines can prevent infections and actually cause it to not re-occur again. The invention of the Rabies, and Anthrax vaccines not only saved life’s, but helped scientist conduct and produce more accurate and successful research. Discovered by Louis Pasteur, in 1882, the innovation of the rabies vaccine was invented. Rabies is a critical and sometimes fatal infection that one could get with coming in contact with a “rabid” or wild animal. When this virus enters the body and spreads, it travels slowly through all the nerves and all the way to the brain. Once it reaches the brain, it becomes fatal. The number of deaths due to rabies worldwide each year is approximately 55,000. However, due to the invention of the rabies vaccine, the number of fatalities and illnesses decreased by a substantial amount.
Vaccines have been around for hundreds of years starting in 1796 when Edward Jenner created the first smallpox vaccine. Jenner, an English country doctor noticed cowpox, which were blisters forming on the female cow utters. Jenner then took fluid from the cow blister and scratched it into an eight-year-old boy. A single blister came up were the boy had been scratched but it quickly recovered. After this experiment, Jenner injected the boy with smallpox matter. No disease arose, the vaccine was a success. Doctors all around Europe soon began to proceed in Jenner’s method. Seven different vaccines came from the single experimental smallpox vaccine. Now the questions were on the horizon. Should everyone be getting vaccinations? Where’s the safety limit? How can they be improved? These questions needed answers, and with a couple hundred years later with all the technology, we would have them(ncbi.nlm.nih.gov).
The Ebola virus can easily be transmitted through direct contact of blood, organs, secretions of any kind and semen from any person infected. Another method is that of used needles that have been infected. With all countries considered, the 3rd world and the reuse of needles are a common practice, due to lack of funds and supplies. Though recovered patients pose no serious threat, the virus is present up to 7 weeks after being treated. Vomit and diarrhea contain the infected blood and mucus so any contact with this, e.g. in poor drinking water can cause contraction of the virus. Luckily enough Ebola is not airborne and in some cases due to its self-limiting nature, it has been known to die out within a person before killing the host. In one case when a Swiss researcher found the Ebola Tai virus, she contracted it from a chimpanzee. This was during an investigation into the spur of deaths among them at the time. To this day, there is still no evidence as to what host carried the virus before humans and no location of the virus is known.
The symptoms in humans are flu-like symptoms, anything ranging from fever to headache. After a few days after exposure, the human will experience the symptoms of clinical rabies: anxiety, confusion, agitation, hallucinations, and also insomnia (CDC). These symptoms may last two to ten days. Once the clinical symptoms have appeared the fatality rate is very high. To date, there have only been six cases of survival from the clinical stage of rabies (CDC). Incubation period ranges form ten days to one year, but the average is 20 days. Also bites closer to the brain will progress faster and bites in the lower appendages will take longer to spread (Mayo Clinic Proceedings).