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Medical authorities often describe wound healing in terms of overlapping phases that occur in the days, weeks and months following an injury. These phases are hemostasis, inflammation, proliferation and maturation. Hemostatsis is commonly included as a component of the inflammation phase. It is the body’s attempt to quickly stop bleeding without unnecessarily disrupting blood flow. Injuries are unique and the healing process for those injuries varies depending on a number of factors including the depth, size, type and location of the wound. The presence in duration of infection and the health and age of the person injured. So, generally speaking, when the skin in injured, for example, by a cut or a puncture wound, after the bleeding is stopped, a blood clot is left within the tissue and a scab will usually form over the wound in the first few days.
The beginning of the inflammation phase is marked by the migration of white blood cells into the wound. During the first few days after the injury, the body tries to clean up the wound site. Bacteria, dirt and damaged cells, as well as other types of debris, can be present in the wound. White blood cells called neutrophils migrate from the blood stream, through the tissue and into the wound. These cells begin to engulf and digest the contaminants. This migration of cells from the bloodstream to the wound begins at the capillaries. Capillaries are the tiny vessels that connect the very small arteries to the very small veins. As the blood passes from the small artery through the capillaries and into the small vein, oxygen and nutrients are delivered to the tissue and carbon dioxide and other waste products are absorbed and carried away. The migration of t...
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... end of the maturation phase, the wound is permanently sealed with collagen-rich scar tissue that has little of the vibrant cell activity present at the proliferant phase.
To sum up …I’ve written and touched on the four phases of wound healing and seen how the wound is cleaned during the inflammation phases. How the clot is replaced with granulation tissue and a new covering of the dermal cells in the proliferation phases and how the wound is eventually closed and sealed by the end of the maturation phase.
Works Cited
Library and Information Resources Network, Inc. (n.d.). Retrieved from http://search.proquest.com.ezp-02.lirn.net/docview/195969294/14348A6DC835938A65C/2?accountid=158801
Clifforth, S. R. (2007). ABC of wound healing. edited by keith harding and joseph grey. World Journal of Surgery, 31(6), 1364. doi:http://dx.doi.org/10.1007/s00268-007-9026-2
Margination and adhesion to the endothelium, in which accumulation of leukocytes occurs along the endothelial wall for adhesion. Afterward, these adhesions cause the separation of endothelial cells, allowing the leukocytes to extend and Transmigrate through the vessel walls. Followed by the response of chemical mediators(chemotaxis) that influence cell migration via an energy directed process which triggers the activation of Phagocytosis, in which monocytes, neutrophils, and tissue macrophages are activated to engulf and degrade cellular debris and
As a standard precaution against bodily fluids or blood borne pathogens the medical assistant and the doctor would don their personal protective equipment (PPE) such as gloves, face shield, and gown. Next, the medical assistant will prepare the following materials in preparation of the procedure: 1% or 2% lidocaine in a 10cc syringe/25 gauge needle, skin prep solution, #11 scalpel blade with handle, gauze, hemostat, scissors, iodoform, tape, and culture swab. After the materials have been prepped the doctor will clean the abscess with skin prep and drape the wound with sterile fenestrated drape. Anesthetic in the form of lidocaine with a 10cc syringe and 25-gauge needle will be injected around the abscess. The doctor will allow 3-5 minutes for the anesthetic to take affect before making an incision into the abscess. Once the incision is made the doctor will allow pus to ooze and drain out. While the pus is draining out, the culture swab will be inserted in to the abscess where a culture is taken so the origin of the infection is identified incase further treatment is needed. Using the hemostat the doctor will explore the abscess and continue to soak up the pus with the gauze. With a syringe and normal saline the doctor will irrigate
In 1865 before an operation, he cleansed a leg wound first with carbolic acid, and performed the surgery with sterilized (by heat) instruments. The wound healed, and the patient survived. Prior to surgery, the patient would need an amputation. However, by incorporating these antiseptic procedures in all of his surgeries, he decreased postoperative deaths. The use of antiseptics eventually helped reduce bacterial infection not only in surgery but also in childbirth and in the treatment of battle wounds.
The smallest arteries are called arterioles and they play a vital role in microcirculation. Microcirculation deals with the circulation of blood from arterioles to capillaries to venules the smallest veins. The liver, spleen and bone marrow contain vessel structures called sinusoids instead of capillaries. In these structures blood flows from arterioles to sinusoids to venules.
It regulates the ratio between epithelial cells and collagen fibers as well as changes in their morphology. The imbalance of collagen metabolism and its arrangement is attributed to many factors which result in increased synthesis of collagen by fibroblasts and myofibroblasts, which in turn inhibit the activity of collagenase, leading to extensive scar hyperplasia. Matrix changes, mainly changes in fibronectin and mucopolysaccharides, result in scar stiffness. MEBO Scar Ointment can accelerate the re-arrangement of twisted collagen andreduce proliferation of fibroblasts, thus restricting scar hyperplasia. [11,13,14,15 ,21] The accumulation and synthesis of mucopolysaccharide can also be reduced once local tissues are compressed, thus reducing generation of collagen and the corresponding scar tissue. [11] Moreover, massaging the MEBO Scar ointment onto old scars can potentially reduce blood supply within scars, decrease synthesis of collagenous fiber, and,reduce α2-M (alpha 2-macroglobulin) globulin of collagenase in serum which facilitates collagenase activity and speeds up disintegration of collagen in old scars,this facility by applying MEBO scar ointment .
The Structure and Functions of the Arteries Arteries are blood vessels that convey blood from the heart to the tissues of the body. The arteries expand and then constrict with each beat of the heart, a rhythmic movement that may be felt as the pulse. Arteries are usually named from the part of the body that they are found, for example; brachial artery found in the arms, metacarpal artery found in the wrist; or from the organ which they supply as the hepatic artery supplies the liver, pulmonary artery brings deoxygenated blood the lungs. The facial artery is the branch of the external carotid artery that passes up over the lower jaw and supplies the superficial portion of the face; the haemorrhoidal arteries are three vessels that supply the lower end of the rectum; the intercostal arteries are the arteries that supply the space between the ribs; the lingual artery is the branch of the external carotid artery that supplies the tongue. The structure of the artery enables it to perform its function more efficiently.
When the first line of defense fails, the bodies second line of defense kicks in. Natural killer cells, neutrophils, macrophages, inflammation, fever and transferrin and lactoferrin kick in to eliminate microbes. These also prevent infectious diseases. Keeping infection out of the intravenous site is very important. As long as the bodies defense mechanisms are working properly and aren’t compromised, the process is made
Pressure ulcers are one of the most common problems health care facilities often face which causes pain and discomfort for the patient, cost effective to manage and impacts negatively on the hospital (Pieper, Langemo, & Cuddigan, 2009; Padula et al., 2011). The development of pressure ulcers occur when there is injury to the skin or tissue usually over bony prominences such as the coccyx, sacrum or heels from the increase of pressure and shear. This injury will compromise blood flow and result in ischemia due to lack of oxygen being delivered (Gyawali et al., 2011). Patients such as those who are critically ill or bed bounded are at high risk of developing pressure ulcers (O'Brien et al., 2014).
the injury. In some cases, the trauma and the surgery become too much for the body to handle,
Due to the fact that people with chronic wounds are generally seen on a weekly basis in a clinic, the
Fluid enters the lymphatic system and returns it to the circulatory system. The fluid enters the system through the lymph vessels. The lymphatic vessels convert into larger vessels termed lymphatic veins which have lymphatic ducts which contain valves which prevent the backflow of the lymph fluid. These veins contain smooth muscles which also helps the movement of fluid. These veins lead to the lymph nodes. After the lymph is filtered in the node it then travels through the efferent lymphatic vessels that drain into the circulatory system veins
The normal wound healing process mainly consists of four main stages being haemostasis, inflammation, proliferation or new tissue formation, and tissue remodeling or resolution. For a wound to heal well the above mentioned stages should occur in a sequential and orderly manner. Disturbances, abnormalities and delays in any of the above stages may lead to impaired healing or even chronic wounds. In adults, this process of normal healing takes place in the following steps (1)rapid haemostasis (2)appropriate inflammation (3)mesenchymal cell differentiation, proliferation, and migration to the wound site (4)suitable angiogenesis (5)prompt re-epithelialization and (6) proper synthesis, cross-linking, and alignment of collagen to provide strength to the healing tissue.
Acute inflammatory is the initial response of the body following an injury “Acute inflammation is short term and can be measured in hours or days” (Battle, 2009, P 238). This response is achieved through the release of leukocyte and plasma into the injured tissues. The predominant cells in acute inflammation are neutrophils. This inflammatory response involves the local vascular and immune system within the tissue. There are five cardinal signs signifying acute inflammation: 1) warm and 2) redness due to increased blood flow to the injured ...
Our approach in managing wounds was far from being optimal in our own setting. After having read the article of Sibbald et al (1) and assisting to presentations during the first residential week-end, our approach at St. Mary 's Hospital Center 's Family Medicine Clinic must change. We were not classifying wounds as healable, maintenance or non-healable. We were always considering the wounds in our practice as healable despite considering the system 's restraints or the patients ' preferences. In the following lines, I will define and summarize the methods one should use in order to initial management of wounds and how to integrate it better to our site. The first goal we need to set is to determine its ability to heal. In order to ascertain if a wound is healable, maintenance or a non-healable wound.
The white blood cells destroy any unfamiliar pathogens in the bloodstream and can cause inflammation. Therefore, the inflammation causes a surplus of white blood cells to clot the wound for healing.