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Inflammation which is part of the innate immune system is a process by which the body reacts to injury protecting it from infection and foreign substances with the help of the body’s white blood cells “Inflammation can be defined as the body’s local vascular and cellular response to injury caused by factors that invade and injure the body from the outside (exogenous factors) or factors within the body that result in cellular or tissue injury (endogenous) factors” (Battle, 2009, P 238). Factors such as bacteria, viruses, burns, frostbite, chemical irritants, immune reactions and physical injury are examples of factors that can cause inflammation through different mechanisms. It is a protective mechanism with rapid response that neutralizes or destroys agents that causes injury and creates a barrier that limit the injury and prevents its spread to normal tissues (Battle, 2009). Also, it has elements that removes debris and heals the wound generated by the injury. It can be divided into acute and chronic inflammation.
Acute inflammatory is the initial response of the body following an injury “Acute inflammation is short term and can be measured in hours or days” (Battle, 2009, P 238). This response is achieved through the release of leukocyte and plasma into the injured tissues. The predominant cells in acute inflammation are neutrophils. This inflammatory response involves the local vascular and immune system within the tissue. There are five cardinal signs signifying acute inflammation: 1) warm and 2) redness due to increased blood flow to the injured ...
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What is the physiologic mechanism causing the wound to become red, hot, swollen, and painful?How is this different than the inflammatory response that might occur in an internal organ?
Sepsis is defined as an exaggerated, overwhelming and uncontrolled systemic inflammatory response to an initially localised infection or tissue injury, which may lead to severe sepsis and septic shock if left untreated (Daniels, 2009; Robson & Daniels, 2013; Dellinger et al, 2013; Perman, Goyal & Gaieski, 2012; Vanzant & Schmelzer, 2011). Septic shock can be classified by acute circulatory failure as a result of massive vasodilation, increased capillary permeability and decreased vascular resistance in the body, causing refractory hypotension despite adequate fluid resuscitation. This leads to irreversible tissue ischaemia, end organ failure and ultimately, death (McClelland & Moxon, 2014; Sagy, Al-Qaqaa & Kim, 2013, Dellinger et al, 2013).
The immune system is made up of a network of cells, tissues, and organs that work together to protect the body, and it defends the body from “foreign invaders.” Immunity can be divided in two three different defenses, and these are defined as first, second and third lines of defense. The first line of defense for the immune system is the primary defense against pathogens entering the body from the surface in order to prevent the start of disease and infection. Some examples of the first line of defense is the skin, protecting the external boundaries of the body, and the mucous membranes, protecting the internal boundaries of the body. Although the skin and mucous membranes work on the internal and external boundaries, they both release chemicals
Inflammation is the reaction of the body's tissue to an injury, fundamental in the innate and adaptive response. Signs of inflammation are characterised as rubor, dolor, tumor and calor, meaning redness, pain, swelling and heat respectively. The benefits of inflammation outweighs the adverse effects and is important for survival although too much inflammation might cause harm, like sepsis or septic shock[4].
In some diseases, the inflammation is clearly an immune reaction, the body's defense against invading microorganisms. In others, the cause is different or unknown. Infectious Arthritis This disease is most common in young adults. Infection in a joint is usually caused by bacteria or other microorganisms that invade the joint from its blood vessels.
... the context of chronic illness: a family health promoting process. Journal of Nursing and Healthcare of Chronis Illness 3, (3), 283-92.
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The inflammatory response is a nonspecific response to cellular injury and bacterial invasion. Inflammation is the primary defense in early gingivitis. Biofilm can initiate an inflammatory response if it is left undisturbed for as little as seventy two hours. Redness and swelling are two of the cardinal signs of inflammation and can be observed clinically in gingivitis. Histamine is released by mast cells and responsible for the redness and swelling of tissues. Histamine causes both an increase in vascularity and permeability of blood vessels at the site of injury. Swelling may occur in response to the accumulation of fluid at a specific site. The inflammatory response includes cellular components of the immune system polymorphonuclear leukocytes and macrophages. Polymorphonuclear leukocytes are crucial to the cellular immune response. Polyporphonuclear leukocytes are the first cells that arrive at an inflammatory site. Polymorphonuclear leukocytes arrive at the site via chemotaxis, and begin to phagocytize bacteria. As the disease continues and the inflammatory reaction is not strong enough to subside the bacterial infection the immune response is further
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U.S. Department of Health and Human Services, Office of Disease Prevention and Health Promotion. (2014). Quick guide to health literacy. Retrieved from website: http://www.health.gov/communication/literacy/quickguide/factsbasic.htm
National Center for Chronic Disease Prevention and Health Promotion. (2014, January 23). Division of nutrition, physical activity, and obesity. Retrieved from http://www.cdc.gov/nccdphp/dnpao/index.html
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The white blood cells destroy any unfamiliar pathogens in the bloodstream and can cause inflammation. Therefore, the inflammation causes a surplus of white blood cells to clot the wound for healing.