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Essays on gene therapy
Essay on gene therapy
Essay on gene therapy
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Gene therapy is considered to be a relatively new form of treatment that could eventually benefit people who have one of the thousands of diseases caused by a genetic disorder. Using gene therapy can treat, prevent or cure these types of diseases1. This “medicine of the future” has been worked on for decades but there is not a huge amount of success for human patients because gene therapy isn’t completely practical yet. Human clinical trials are still in the research phase because gene therapy can be unpredictable. Very few patients have received gene therapy. Researchers are working extremely hard to break through the challenges they are facing and make sure that gene therapy is safe and effective for humans.
Gene therapy works in a variety of ways. It can be used to solve the problem of having missing genes by adding a gene to fight off a disease3. The main purpose of gene therapy is to help fix mutations in the body by replacing the genes that are functioning incorrectly with ones that are functioning correctly. Some mutations are harmless but others can cause a patient to develop a disease. The DNA in genes are responsible for carrying the information that makes proteins. Proteins can be considered “the building blocks of our body”1 so if a gene is mutated and becomes harmful it can stir up many problems. Using gene therapy cannot only stop a protein from causing harm by returning its normal function; it can also give new functions to a protein to benefit a patient2. By going through this process we can treat diseases at the source instead of using medication to hide symptoms4.
There are multiple methods that are used to deliver the correct genetic material to the defective genes. One of the methods is to use a vector. Vec...
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...positive sides of this is that in some cases patients only need to complete the process once so there won’t need to be multiple payments. On the negative side, many patients need to undergo several treatments which means several payments. There are a lot of people who disagree but many agree with gene therapy. In fact, a survey taken more than three years ago showed that more than half of the people in the United States thought genetic engineering was acceptable. The opinions differ world wide because in Japan the survey revealed that more than seventy percent thought genetic engineering was unacceptable4. Although many people disagree with gene therapy, they forget that for some people this is a matter of life or death. As long as people keep this in mind and don’t get greedy we should be able to peacefully proceed with gene therapy without any problems.
Could you imagine being able to create new organs, tissues, muscles, and even food? With embryonic stem cell technology, believe it or not, these things are possible. Stem cells are the body's raw materials. Specifically, they are cells from which all other cells with specialized functions are generated. Under the right conditions in the body or in a laboratory, stem cells can divide to form more cells called daughter cells. These daughter cells either become new stem cells or turn into specialized cells with a more specific function, such as blood cells, brain cells, muscle cells or bone cells. The possibilities are almost endless. The debate and main issue with this technology is that the actual stem cells come from embryos. Embryos are an unborn or unhatched offspring in the process of development. Although there is controversy surrounding these cells, embryonic stem cells should continue to be researched and used, because they have so much potential.
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
Gene therapy is reinserting certain genes that helps deal with genetic diseases. There are three basic forms of this gene therapy. The first is Gene Inactivation Therapy in which the transferred gene neutralizes the proteins and evens out the amount or rids of the defective proteins. Another type is Gene Augmentation Therapy where the original form of the gene or the normal form of the gene is inserted into one of the cell’s chromosomes. This procedure is used normally when a gene with little activity or a deleted gene is the cause for the genetic disease. The third type of gene therapy is Gene Replacement Therapy. This form is used when the genetic disease involved specific genes that are necessary for proper functioning. The normal gene being put in place of the mutant gene accomplishes this form of gene therapy.
Gene therapy is an experimental technique that allows doctors to insert a gene into a patient’s cell rather than using drugs or surgery. Gene therapy is a process of which defective or undesired genes in the body with “normal” genes. A vector is re-engineered to deliver the gene to a target cell. Then the gene is transferred to the cell’s nucleus and must be activated in order to function. The main focus of gene therapy is to replace a lost or improper gene with a new functional copy into a vector that is inserted into the subject’s genome by way of penetrating its DNA. Gene therapy can be done outside of the body known as ex vivo by way of taking cells form patients bone marrow or blood and then growing them in a laboratory. Thus the corrected copy of the gene is inserted into the cells before being put back into the body. Gene therapy can also be done in vivo which can be done directly to the patient’s body. The word gene therapy really defines the management of genetic information that is encased in the cells, however, in most recent procedures the available technology is closely related in adding new genetic information, and many researchers favor the term gene transfer rather than gene therapy to mirror the reason that the purpose of gene work cannot always be therapeutic.
Just as there are different types of people who look at one glass of water and describe it as half full or half empty, the public has many different views on the future of our society. Gene therapy is also a glass that can be viewed in different angles – different perspectives. Some say it has great potential to shape the ideals of our future, while others believe it signifies intolerance for disabilities, imperfections that supposedly deplete from a person’s interests, opportunities and welfare (quoted by Peter Singer, xviii). This global issue has brought people with different opinions in the open, arguing their views using history, morality and foresight.
Human gene therapy is a method used in the medical field that treats diseases at a molecular level, by solving the source of the problem; our genes. Today, diseases and disorders are commonly treated by solving the symptoms, the surface of the problem. Many disorders and diseases are caused by defective proteins and within those defective proteins are damaged and defective genes. These defective genes can be treated through gene therapy. Gene therapy is not new and has been developed and improved by researchers for the past couple years. Being an experimental technique, gene therapy also has its pros and cons, but so far is showing positive and rising success rates.
Human cloning research has once been the subject of terrifying science-fiction films and novels, science experiments gone wrong, accomplished only by the evil scientists twirling their moustaches. However, ideas presented on page and screen are rarely accurate. The possibility of cloning an exact copy of another human with one already fully developed is almost impossible, but through meticulous research, scientists have discovered the numerous benefits of cloning humans, either with individual cells or an embryo.
Gene therapy works in three ways; it works to replace a missing or defective gene with a normal one, replace a faulty gene so that it will function properly and it works to activate and deactivate a gene, allowing it to “switch” on and off. Gene therapy is done by the deliverance of a gene to a cell via a carrier, or vector, such as a virus. Scientists lean more towards using a virus because they can seek out particular cells and transfer pieces of deoxyribonucleic acid into them. Scientists also take advantage by deactivating their harmful characterizes and modifying them to carry particular gene into designated cells. After gene therapy is done, the genes can then stimulate the production needed for standard functioning, allowing that gene to return to its previous normal state. Therefore, if a patient were to be in the beginning stages of cancer, gene therapy would seek out the cancerous gene and replace it with a healthy one and minimizes the disease from
Gene therapy gives people who suffer from genetic diseases a chance to lead a normal life. Dangerous diseases, such as AIDS, SCID, Thalassemia and ADA can be cured successfully. In September 5, 2006, two people with advanced melanoma received Gene therapy and they got recovery soon. This is a breakthrough in cancer gene therapy. Gene therapy uses patients own cells to cure diseases, and, therefore, no rejection to their bodies. Furthermore, patients could get permanent cure from gene therapy without recurrence.
From the very first sentence of David Almond’s enchanting novel, Skellig, the reader is addicted to the mystery behind the unknown presence in the garage of 10-year-old Michael’s new home on Falconer Road. David Almond’s Skellig, takes the reader through a series of emotions with Michael and his new neighbour Mina and gradually explores the character of Skellig. Almond’s character Skellig is portrayed to be rude and mysterious through dialogue and his bird-like or angelic qualities are demonstrated through both characterisation and imagery in the descriptions of Skellig’s appetite and appearance. The character of Skellig is revealed to the reader by using the mentioned
"What's the worst that can happen to me? I die, and it's for the babies," said Jessie Gelsinger as he left for the hospital to receive gene therapy treatment. (Stolberg) People risk their lives everyday in the name of science. One such science that people have recently been drawn to is gene therapy. Although, gene therapy may be new and exciting and it may be helping to find cures to diseases we only dreamed of curing, we have to remember it is dangerous. It needs to be done with much supervision. Every new step we take in the advancement of gene therapy should be thought over because the consequences could reach farther then we ever believed they could. There are so many dangers of the techniques used that can lead to consequences as serious as death. The government imposes many guidelines, and it needs to stay that way. The biggest dangers, however, may be in what is to come.
"The aim is to decrease the fear of a brave new world and to encourage people to be more proactive about their health. It [Gene therapy] will help humans become better physically and even mentally and extend human life. It is the future” (Hulbert). Dr. Hulbert, a genetic engineer, couldn’t be anymore right; more time, money, and research needs to be put into gene therapy and genetic engineering, since it can cure certain illness and diseases that are incurable with modern medicine, has fewer side-effects than conventional drugs or surgery, and allows humans to be stronger physically and mentally at birth. Gene therapy or genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population (NIH). It essentially means that we can change DNA to make an organism better. Genetic engineering is used with animals and plants every day; for example with genetic...
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
In the end, gene therapy in humans needs to come a long way before it will be widely accepted, but there is great potential in the technology and it needs to be pursued. Bibliography Anderson, W. F. (1992). The Species of the World. Human Gene Therapy -. Science, 256 (5058), 808-813.