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Ethical / moral issues of gene therapy
Gene therapy pros and cons
Ethical / moral issues of gene therapy
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What if there was a way to cure cancer, change skin color, or increase athleticism. Gene therapy promises to do all this and more. It aims to correct genetic abnormalities by inserting therapeutic genes into the body. Gene therapy is a fairly new practice, but it is not safe or reliable enough to become a standard treatment. One must also consider the ethical questions that arise. Gene therapy offers undeniable benefits, but the risks it poses need to be addressed before this technology can become common practice.
The goal of gene therapy is to correct the unwanted trait or disease by introducing a modified copy into the cell. Notice that the purpose is not to replace defective genes in the host cell, rather it is to provide a new copy, so the correct protein is expressed, or at least the defective gene is neutralized (Blachford 462). Humans are made of trillions of cells, each with a specific function. Contained in each cell is DNA, carrying the blueprint of life in the form of genes that determine inherited characteristics. A mutation is a change in the DNA sequence of a gene. Small mutations may have a profound effect upon the body. For example, hemophilia is caused by the mutation of a single gene. The most obvious targets for gene therapy are single gene defects, where a single, faulty gene causes a disease. While easy, single gene targets for gene therapy include hemophilia, cystic fibrosis, muscular dystrophy and SCID, gene therapy may have the potential to cure HIV, malignant melanoma, kidney cancer, Gaucher disease, breast cancer and lung cancer (Sinnott). Since the 1970’s, scientists have been manipulating genes through gene splicing. Gene splicing involves removing a fragment of DNA containing the specific DNA sequenc...
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...cientist will have to learn how to turn on specific genes when a protein of enzyme is low, and off to avoid too much to ensure the delicate chemical makeup of our bodies is not disrupted. (Blachford, 467) Although there are many risks of gene therapy, the benefits remain to enticing to ignore.
Gene therapy poses many risks, but may prove the ideal solution for countless diseases. As seen throughout the past few decades, gene therapy can cure genetically inherited diseases by introducing therapeutic genes into the body. Critics may argue that there are moral and ethical problems associated with this novel technique, but for the most part scientists realize the importance this advancement will have. Gene therapy may be the key to curing dozens of diseases, and has endless possibilities, but more research is needed before its safe or accepted as common practice.
Gene therapy is the application of the technique where the defect-causing "bad" genes are replaced by correct "good" genes. The idea of gene therapy is to treat the disease by correcting the "bad" DNA (Deoxyribonucleic acid) rather than the current me thod of providing drugs, or proteins not produced by the defective gene. Gene therapy addresses the problem first hand by directly working with the genetic information causing the disease. From the book Shaping Genes, Dr. Darryl Macer says "It is like f ixing a hole in the bucket, rather than trying to mop up the leaking water." There are two kinds of gene therapy, somatic cell gene therapy and germline gene therapy.
Gene therapy is reinserting certain genes that helps deal with genetic diseases. There are three basic forms of this gene therapy. The first is Gene Inactivation Therapy in which the transferred gene neutralizes the proteins and evens out the amount or rids of the defective proteins. Another type is Gene Augmentation Therapy where the original form of the gene or the normal form of the gene is inserted into one of the cell’s chromosomes. This procedure is used normally when a gene with little activity or a deleted gene is the cause for the genetic disease. The third type of gene therapy is Gene Replacement Therapy. This form is used when the genetic disease involved specific genes that are necessary for proper functioning. The normal gene being put in place of the mutant gene accomplishes this form of gene therapy.
A molecular biologist by the name of James Watson once said, “we used to think that the fate was in our stars, but now we know that, in large measure, our fate is in our genes.” The Oxford Dictionary defines gene therapy as the transplantation of normal genes into cells in place of missing or defective ones in order to correct genetic disorders. Gene therapy has the ability to prevent, treat, and even cure diseases by replacing a faulty gene with a stable, healthy one (American Medical Association). Aldous Huxley’s, Brave New World, relates to gene therapy because they program each embryo with how they should live. This essay will first talk about why gene therapy is done and how it works.
Human gene therapy is a method used in the medical field that treats diseases at a molecular level, by solving the source of the problem; our genes. Today, diseases and disorders are commonly treated by solving the symptoms, the surface of the problem. Many disorders and diseases are caused by defective proteins and within those defective proteins are damaged and defective genes. These defective genes can be treated through gene therapy. Gene therapy is not new and has been developed and improved by researchers for the past couple years. Being an experimental technique, gene therapy also has its pros and cons, but so far is showing positive and rising success rates.
Over 40 years ago, two men by the names of James Watson and Francis Crick discovered deoxyribonucleic acid, or DNA. DNA is hereditary material in humans and almost all other organisms (What is DNA?). From this finding, gene therapy evolved. Today, researchers are able to isolate certain specific genes, repair them, and use them to help cure diseases such as cystic fibrosis and hemophilia. However, as great as this sounds, there are numerous ethical and scientific issues that will arise because of religion and safety.
Gene therapy works in three ways; it works to replace a missing or defective gene with a normal one, replace a faulty gene so that it will function properly and it works to activate and deactivate a gene, allowing it to “switch” on and off. Gene therapy is done by the deliverance of a gene to a cell via a carrier, or vector, such as a virus. Scientists lean more towards using a virus because they can seek out particular cells and transfer pieces of deoxyribonucleic acid into them. Scientists also take advantage by deactivating their harmful characterizes and modifying them to carry particular gene into designated cells. After gene therapy is done, the genes can then stimulate the production needed for standard functioning, allowing that gene to return to its previous normal state. Therefore, if a patient were to be in the beginning stages of cancer, gene therapy would seek out the cancerous gene and replace it with a healthy one and minimizes the disease from
In September 14, 1990, an operation, which is called gene therapy, was performed successfully at the National Institutes of Health in the United States. The operation was only a temporary success because many problems have emerged since then. Gene therapy is a remedy that introduces genes to target cells and replaces defective genes in order to cure the diseases which cannot be cured by traditional medicines. Although gene therapy gives someone who is born with a genetic disease or who suffers cancer a permanent chance of being cured, it is high-risk and sometimes unethical because the failure rate is extremely high and issues like how “good” and “bad” uses of gene therapy can be distinguished still haven’t been answered satisfactorily.
In the past 40 years, scientists have developed and applied genetic engineering to alter the genetic make-up of organisms by manipulating their DNA. Scientists can use restriction enzymes to slice up a piece of DNA from an organism with the characteristics they want and spliced (joint) to a DNA from another organism. DNA that contains pieces from different species is called recombinant DNA, and it now has different genetic material from its original. When this DNA inserted back into the organism, it changes the organism’s trait. This technique is known as gene-splicing (Farndon 19).
Gene therapy focuses on the replacement of defective genes with modified functioning genes. Many diseases are caused by a defective gene meaning the body is incapable of producing essential proteins or enzymes. In its simplest form, gene therapy aims to identify the defective gene and fix this gene with the replacement of a normal gene (Senn).
"The aim is to decrease the fear of a brave new world and to encourage people to be more proactive about their health. It [Gene therapy] will help humans become better physically and even mentally and extend human life. It is the future” (Hulbert). Dr. Hulbert, a genetic engineer, couldn’t be anymore right; more time, money, and research needs to be put into gene therapy and genetic engineering, since it can cure certain illness and diseases that are incurable with modern medicine, has fewer side-effects than conventional drugs or surgery, and allows humans to be stronger physically and mentally at birth. Gene therapy or genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population (NIH). It essentially means that we can change DNA to make an organism better. Genetic engineering is used with animals and plants every day; for example with genetic...
Over the past few decades, advances in technology have allowed scientists to actively manipulate the genetic sequence of an organism through a process called 'genetic engineering'. Many believe that this is a technique which we should exploit and take full advantage of as, after all, it may be the key to curing many hereditary diseases such as heart disease and cancer. It may very well be the solution to overcoming evolutionary barriers and allow us to breed new species. However, if you consider the unknown consequences we may have to face as a result of our futile experimenting, you would find that messing with a system as intricate as nature for curiosity's sake is hardly justifiable.
Since its inception, gene therapy has captured the attention of the public and ethics disciplines as a therapeutic application of human genetic engineering. The latter, in particular, has lead to concerns about germline modification and questions about the distinction between therapy and enhancement. The development of the gene therapy field and its progress to the clinic has not been without controversy. Although initially considered as a promising approach for treating the genetic of disease, the field has attracted disappointment for failing to fulfil its potential. With the resolution of many of the barriers that restricted the progress of gene therapy and increasing reports of clinical success, it is now generally recognised that earlier expectations may have been premature.
Genes are made of DNA – the code of life (Gene Therapy- The Great Debate!). The changes in genes may cause serious problems, which we called genetic disorder. In theory, the only method to cure genetic disorders is gene therapy, which basically means the replacement of genes in order to correct the loss or change in people’s DNA. Although gene therapy gives patients with genetic disorders a permanent cure, it is controversial because it has safety and efficacy problems, and raises ethical issues.
Position Paper: Gene Therapy in Humans. Advancements in science and medicine are usually accompanied by a myriad of ethical and moral implications. The fairly recent advancement in genetics, called gene therapy, is no exception to the baggage of polarizing views that come with new technology. Gene therapy is an extremely hot topic in both the scientific world and everyday life. New technology, discoveries, and breakthroughs are rapidly occurring in the field every day.
What are the risks and what are the possible benefits? Currently, gene therapy is one of the only ways to change the genetic makeup of an animal or human. Also, the chance of gene therapy being successful in animals is fifty percent, while in humans it is five percent. Human Genetics Alert believes “Once we begin to consciously design ourselves, we will have entered a completely new era of human history, in which human subjects, rather than being accepted as they are, will become just another kind of object, shaped according to parental whims and market forces”. HGA provides background information on the currently available resources used in Genetic Engineering.