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Statement of problem osteogenesis imperfecta
Statement of problem osteogenesis imperfecta
Statement of problem osteogenesis imperfecta
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This study analyzed skull radiographs of 195 patients with osteogenesis imperfecta. Many people with osteogenesis imperfecta have a large number of wormian bones and are diagnosed with having SNWB (significant number of wormian bones) when they have 10 or more visible wormian bones. However, those with osteogenesis imperfecta are not the only ones with SNWB as it can also occur in other skeletal diseases and in cases of ‘‘purposeful skull deformation.’’ In this study, they found that a significant number of wormian bones occurred in all types of osteogenesis imperfecta and that 58% of patients with OI types I, III, and IV were positive for SNWB. This study found a strong correlation between occurrence of SNWB and a patient’s OI disease severity.
What is meant by a “complete, comminuted, intertrochanteric fracture of the right hip”? A complete, means that the bone is broken completely through a communication means that the bone has been broken into many pieces and a intertrochanteric means that it involves the greater and lesser trochanter of the femur bone.
In order to study the gene mutation that is supposed to cause Paget’s Bone Disease researchers had to have viable candidates to host the gene mutation. They found the best candidate to host the gene mutation in mice so they implanted the gene mutation in embryos of mice offspring. The researchers hypothesized that p62P394L is sufficient to induce PDB, especially since the p62 gene is responsible for encoding 62 kDa protein which functions in signaling osteoclast precursors. Results were found by fixing the first through fifth lumbar vertebra of four, eight, and twelve month old homozygote, heterozygote and WT littermates in 10% buffered formalin for 24- 48 hours. The first through fourth vertebra were then completely decalcified while the fifth was not. Longitudinal sections of both decalcified and undecalcified vertebra were cut, mounted on glass slides and stained to analyze. The mice with p62P394L had histologically normal bones, indicating that p62 mutation is not enough to induce Paget’s disease of the bone in vivo, there are additional factors necessary. Knowing osteitis deformas is due to hyper responsive multinucleated osteoclasts, it seemed a sensible suggestion. However, there are many other variables that should be factored when considering possible causes for osteoclast hyperformation. If p62P349L is present, doesn’t necessarily mean a person will get PDB, though an environmental factor such as measles could easily open up transduction pathways that could eventually lead to pagetic bone lesions. We find this study to be a stepping stone for future researchers to use in order to actually identify what causes Paget’s bone disease. (Hiruma, Kurihara, Subler, Zhou, Boykin, Zhang, Ishizuka, Dempster, Roodman & Wi...
Dear Aunt Sally, as woman reach menopause, the estrogen in their body rapidly declines. Our bones are constantly remolding themselves all through life. As estrogen is a necessary hormone in bone development, the onset of menopause and subsequent loss of estrogen can be catastrophic for our skeletal system. The bone loss starts off as Osteopenia.
Osgood-Schlatter Disease or syndrome (OSD) is an irritation of the patellar ligament at the tibial tuberosity (Dhar). Osgood-Schlatter Disease is claimed by some to not actually be a disease (Sims). But is rather a collection of symptoms that involves the tibial tubercle epiphysis (Sims). Osgood-Schlatter Disease affects as many as 1 in 5 adolescent athletes (Diseases and Conditions: Osgood-Schlatter Disease). Some other common names for this disease are Osteochondrosis, Tibial Aponphysitis, Tibial Tubercle Apophyseal Traction Injury, Morbus Osgood- Schlatter, and Rugby Knee (Dhar). “This can cause multiple sub-acute avulsion fractures along with inflammation of the tendon, leading to excess bone growth in the tuberosity and producing a visible lump which can be very painful when hit (Dhar). Activities such as kneeling may irritate the tendon further (Dhar).”
Osteogenesis Imperfecta (OI), also called fragile bone ailment or Lobstein disorder, is an inherent bone issue portrayed by weak bones that are inclined to break effortlessly with practically zero cause. A arrangement of various sorts of OI is regularly used to depict how seriously a man with OI is affected.OI is brought on by hereditary deformities that influence the body's capacity to make solid bones. In predominant established OI, a man has too little sort I collagen or a low quality of sort I collagen because of a transformation in one of the sort I collagen qualities which makes the bones
Osteonecrosis has become a subject of interest amongst orthopaedic surgeons predominantly during the last four to five decades.
Despite ongoing research, the cause of osteosarcoma is still unknown. Occurring in 2 persons per million per year (Michael et al., 2006) osteosarcoma is the most common primary tumor of the bone, but yet its incidence amongst malignant tumors is rare. However there are numerous factors that have been shown to effect prevalence. Osteosarcoma occurs predominantly in males, although the tumor does have a tendency to develop earlier in females (American Cancer Society, 2014). The risk of osteosarcoma is highest for people who are aged between 10 and 30. Most common however is during the teenage growth spurt, due to the rapid bone growth and higher chance of a mutation occurring in DNA replication. Height can also be a risk factor. Children with osteosarcoma are generally tall for their age, which again indicates a link to rapid bone growth. Osteosarcoma also appears to have a slightly higher prevalence in African Americans than other races. There is also evidence of genetic predisposition being a risk...
Osteogenesis imperfecta is classified by type. In 1979, Dr. David Sillence developed this classification system. Sillence’s system is based upon method of inherit...
Osteopenia can be seen as beginning stage of osteoporosis. Osteopenia is classified when bone density is lower than normal but not so low that it can be classified as being osteoporosis. It can be caused by several different diseases, conditions, or may be something that is natural to the person who has it. It can also be caused by eating disorders, and metabolism disorders. Chemotherapy and medicines such as steroids are also known to be causes as well as being exposed to radiation.
Osteogenesis imperfecta (OI), also known as brittle bone disease, is a rare genetic disorder with the main characteristic being that the bones break very easily, usually for no apparent reason. The major cause of osteogenesis imperfecta is a mutation in the genes that produce collagen. Collagen is the main protein that works toward the production of connective tissue. Individuals with this disorder will produce less collagen than needed, which causes the bone development to be endangered. This could result in bone deformities. There are four types of osteogenesis imperfecta, and in all four types you will see bone fragility with multiple fractures and bone deformities.
The syndrome is caused because of Genetic mutation that replaces connective tissues (muscles) with bones when someone gets injured instead of getting cured. This results in a new skeletal structure. Unfortunately this syndrome does not have any cure and the patients are advised to always be careful and not to fall or have any kind of traumas. They can’t engage in any sports in order to prevent any injuries. Surgery for removal of extra bones is not an option because removal of bones will lead to ingrowth of more bones. From previous cases it is seen that most of the patients suffering from this condition do not live more than 40 years and they die of respiratory
In the United States, there are two kinds of physicians that practice medicine. The Osteopathic medicine is practiced by the Doctor of Osteopathy (D.O.) while Allopathic medicine is practiced by the Doctor of Medicine (M.D.). Due to more physicians hold the degree of MD than the DO's degree, few people recognize Osteopathic Physicians.
The big picture. Where the two schools of medicine differ is in philosophy. Doctors of osteopathy "treat people, not just symptoms," says Karen Nichols, dean of the Chicago College of Osteopathic Medicine. "The course list looks exactly the same, but the M.D.'s focus is on discrete organs. The osteopathic focus is that all of those pieces are interrelated. You can't affect one with out affecting another." That means paying more than simple lip service to the idea of the "whole" patient: It means that diagnosis and treatment rely on an examination of a person's environment and family and general situation as well as his or her body. Not surprisingly, about 65 percent of the nation's 52,000 licensed osteopaths (by comparison, the country boasts at least 900,000 M.D.'s) are primary-care physicians. The American Association of Colleges of Osteopathic Medicine has a description of osteopathic training, as well as short profiles of 20 schools, at www.aacom.org. The D.O. programs and their contact information are listed in the directory section of this book.
Bones were covered in soft material, cellular; the disease was growing quickly on bones. Scientists discovered, the ash from volcanoes, has chocked them to death and Bruno Jabage was the cause of this, samples of ash
Rickets is a bone disease that occurs in children as a result of a Vitamin D deficiency. This disease, which was nearly eradicated in the early 20th century, has become a re-emerging health concern for various countries in the past ten years. Certain factors such as poor nutrition as a result of low socioeconomic status or high concentrations of melanin in the skin can increase the chances of getting rickets. Sufficient Vitamin D levels are crucial to the functioning of the body, especially in the absorption of calcium. This essay will examine the causes, symptoms, pathogenesis, diagnosis and treatment of rickets; as well as the importance of Vitamin D and calcium in the prevention and treatment of this disease.