Osteoarthritis Outcome Assessment

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The primary outcome measurement of this study will be the overall Knee injury and Osteoarthritis Outcome Score (KOOS), including all 5 subscales: pain, symptoms, activities of daily living, sport and recreation function, and knee-related quality of life (Appendix B). The KOOS is a 42-question, self-assessed Likert Scale questionnaire. Each subscale of the KOOS is scored on a scale from 0 to 100, indicating extreme symptoms to no symptoms, respectively. All 5 subscales of the KOOS test have been validated for knee OA and knee injuries that can lead to posttraumatic OA, including meniscal injuries, for both short-term and long-term outcomes.31,32 However, the KOOS test as a total score has not been validated, and thus the KOOS User Guide recommends averaging subscale scores to use as a primary outcome measure for RCTs. As such, the overall KOOS score will be calculated in this manner. All KOOS subscales will also be used individually as primary outcomes. …show more content…

All subscales show good to excellent test-retest reliability, as demonstrated by the following: pain (ICC = 0.85-0.93), symptoms (ICC = 0.83-0.95), activities of daily living (ICC = 0.75-0.91), sport and recreation (ICC = 0.62-0.89), and quality of life (ICC = 0.83-0.95).32 The KOOS is especially appropriate for this study because it was found to be “responsive to change following non-surgical and surgical interventions.”31 Further, the KOOS test includes the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) within it, a test validated for, and commonly used in trials with, elderly subjects with OA.31 The KOOS scale was chosen over the WOMAC scale for this study because, “KOOS subscales ‘Sport and Recreation function’ and ‘Quality of Life’ were more sensitive and discriminative than the WOMAC subscales ‘Pain’, ‘Stiffness’, and ‘Function’” when studied in older individuals with OA who had previously received

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