Myeloma Research Paper

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In 1984, Caeser Milstein of England and George Kohler of Switzerland were awarded Nobel Prize for engineering ‘monoclonal antibodies’. These are made outside the body by the fusion of B-cell and myeloma cells (cancerous cells). These hybrid cells are known as hybridomas.

For the production of the monoclonal antibodies, B-cells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cell are then fused with myeloma tumor cells that can grow indefinitely in cultures (myeloma is B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells, being ous cancer oils cells, will multiply rapidly, as a result, large amounts of the desired antibodies will be

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