The microneedle-array patch design by Yu et al. offers unique characteristics for medical disorders; the smart insulin patch utilizes a closed loop drug delivery mechanism that is safe and painless. This same platform has the potential to treat various conditions such as a severe allergic reaction. Anaphylaxis is a grave, multi-system allergic reaction due to exposure to a chemical allergen that causes activation of the body’s immune system. As a result, various tissues within the body release histamines and other drugs that can cause complications such as inflammation, diffuse erythema, unconsciousness, and shock [6]. In extreme cases, this volatile inflammation can block an individual’s airways to prevent breathing and may lead to death if …show more content…
This will lead to larger perforations on skin and perhaps pain for the patient when applied. Furthermore, the breaking of blood vessels can lead to thrombosis which may cause further complications with drug delivery. Moreover, since the microneedle-array size changes, it must be durable enough to withstand mechanical stresses when applying the patch. This may change the design and material of the microneedle-array patch. It must have higher mechanical strength while remaining biocompatible on initial contact. Also, it must not exhibit toxic degradation products when used. Further research is needed to understand how vesicles can react with a change in the environment from an allergic reaction. For example, the release of histamines can trigger a reaction for the vesicle to disassociate and release epinephrine and antihistamines, similar to how oxygen consumption creates a hypoxic environment in which the GRVs can disassociate to release
When microdermabrasion removes the outer layer of skin the body then goes into a healing mode that promotes the making of new healthier cells. Microdermabrasion is like when one sustains an injury to his skin and the body sends treatment molecules to heal the damage. Mariane Fernandes conducted an experiment with the aim to evaluate the effects of microdermabrasion on skin rejuvenation. Fernandes stated in her article “Effects of microdermabrasion on skin rejuvenation” in the Journal of Cosmetic and Laser Therapy that “Microdermabrasion treatment promoted skin rejuvenation through an increase in skin thickness due to an increase in epidermal thickness and collagen organization” (Fernandes 26). Acne weakens and thins the skin epidermal layers, causing acne scars. Microdermabrasion heals the weak, thin, and fragile skin, which makes the skin smooth and more resistant to other damaging conditions. Doctor Bruce M. Freedman an aesthetic plastic surgeon and assistant professor of plastic surgery at Georgetown University also analyzed the dermatological changes associated with microdermabrasion in “Clinical and histologic changes determine optimal treatment regimens for microdermabrasion” in the Journal of Dermatological Treatment. Freedman’s experiment also yielded results of an increase of epidermal thickness
After watching the documentary The Long Search: Taoism: A Question of Balance—China, I am totally surprised by the details in the video, which explain every single aspect of people’s daily life in Taiwan as religious, especially Taoist. Since China does not consider itself as a nation of religious beliefs and practices, I do not actually think of what Chinese people do everyday as religious. However, after studying Religions in China for a semester, I finally realize that all the Chinese traditions and beliefs have evolved as a mixture of Confucianism, Taoism, and Buddhism. As a result, it all makes sense to see in the video that Taoism is a dominant religion that has deeply influenced individuals’ life in Taiwan.
Insulin: a hormone made by the pancreas that allows your body to use sugar (glucose) from carbohydrates in the food that you eat for energy or to store glucose for future use. Insulin helps keeps your blood sugar level from getting too high (hyperglycemia) or too low (hypoglycemia). Before insulin Diabetes mellitus was a chronic disease that affected thousands of people in Canada and beyond. In the first half of the 20th century, medical professionals understood that diabetes mellitus involved the body’s inability to metabolize food, especially carbohydrates. “Insuline” was already in development as many medical professionals like Joseph Freiherr and Oscar Minkowski, isolated its properties before Banting had his ideas. As well Ancient Greek
The focus for finding an immunological cure for diabetes mellitus type 1 should be directed to prevent maturation or cause inactivation of autoreactive T cells to halt the destruction of insulin-producing beta cells. Inactivation of the autoreactive T cells can be accomplished in two ways. First, antigen presenting cells, such as dendritic cells, that present auto antigens can be modified to prevent maturation or expression of co-stimulatory receptor. Secondly, the T cell can remain in the naïve state or be inactivated after activation by an antigen presenting cell. Diabetes mellitus, commonly known as diabetes, is categorized into type 1, insulin dependent, and type 2, insulin resistant, and the focus will be on the former. Type 1diabetes is a chronic autoimmune disease occurring when insulin-producing beta cells are destroyed by autoreactive CD8 T cells.1 Beta cells are endocrine cells that only secrete insulin and are found in the islets of Langerhans in the pancreas. When the first clinical symptoms of diabetes are apparent in a patient, 80% of the beta cells have already been destroyed.1When large amounts of beta cells are destroyed, it only leaves a fraction of insulin left for the body to utilize, which is often not enough to support function. Type 1 diabetes affects an estimated 30 million people worldwide.1 There is no cure for type 1 diabetes and someone with this disease would need to monitor their blood glucose levels and manually give themselves insulin injections to regulate those levels. However, using insulin injections is not a cure.
The article, “Pancreas Transplant: A Cure for Diabetes?” written by Eli A. Friedman, M.D., explores the possibility of a cure for type 1 diabetes and the implications involving this experimental procedure. The article discusses current procedures and treatments that are commonly used to control type 1 diabetes and highlights provisional treatments that evolved into pancreatic transplant surgery.
... The advanced technology of surface modification in the biomedical sector have the ability to offer not an improvement in the tribological properties only but also to improve the clinical requirements prior and post implantation. Such properties includes cell growth and antibacterial effect.
Have you ever experienced an event that was so significant to you that you felt as if your memory was taking a photograph, keeping the memory implanted in your brain for the rest of your life? This is a prime example of flashbulb memory. Flashbulb memory is a term that pertains to a person’s memory of hearing about extremely shocking events (Goldstein, 2011, p. 209). Flashbulb memory is not the memory for the event itself, but it’s the memory of how the person heard about the specific event (Goldstein, 2011, p. 209). This means that a flashbulb memory includes where you were and what you were doing when you found out about a tragic event (Goldstein, 2011, p. 209). Some key attributes of flashbulb memories are that they are both remembered for long periods of time and are exceedingly vivid (Goldstein, 2011, p. 209). A great way to describe flashbulb memories is to compare them to a photo that never fades, proving how relevant these memories are to those who have them (Goldstein, 2011, p. 209).
Relating to the Audience: Peanut allergy is an epidemic that is growing rapidly especially in the United States, and is most commonly found in children, many of us might have peanut allergy or would know people who do, and today I am going to talk about a possible cure for it, which might change people’s lives.
Before the discovery of Insulin, the life changing hormone that had originated from the research and experiments of Charles Best and Frederick Banting, Type 1 Diabetes was considered to be a death sentence to anyone who was diagnosed with it. It was just a matter of a few months to a year, a countdown until someone found them laying on their deathbed. In the late 1800’s, scientists discovered that by removing the pancreas of a dog, it caused it to suffer from Diabetes. This started a surge of research from many scientists, but no one was able to come up with a cure for this killer disease. That is, until 1921 when Frederick Banting, along with Charles Best, were able to successfully extract insulin fr...
Acute asthma exacerbation occurs when individuals are exposed to an environmental trigger. The disease of chronic asthma creates a medium for hyperresponsiveness. The bronchial environment comprises of inflammation and inflammatory mediators. Consequently, when exposed to an antigen, “increased cellular permeability, smooth muscle contraction, and increased mucus production” occur (Huether & McCance, 2012, p. 689). The ...
Figure 1: Transdermal Patch: A medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into bloodstream. (sv.vt ,no date)
People/ children who have been diagnosed with a threat to anaphylaxis need to strictly follow the Action Plan (Australasian Society of Clinical Immunology & Allergy, 2012) as suggested by their medical practitioner. There is no preventive medication developed for this condition so far. However the only remedy to counter this fatal condition from getting bad to worst is the immediate administration of Adrenaline. Adrenaline(Ep...
Diabetes is a significant and fast growing health concern in the United States. About 16 million Americans have diabetes – and that number increases every day. Every day there is someone who suffers from a diabetic emergency. What is a diabetic emergency? Well, first we must understand what diabetes is. Diabetes is a disease that affects how your body uses blood glucose (or commonly known as blood sugar) your body isn’t able to take the sugar from your bloodstream and carry it to your body cells where it can be used for energy. There are two types of diabetes; Type I (insulin dependent) and Type II (non-insulin dependent). Both types can cause a diabetic emergency. Both types require medical intervention/treatment.
Micro Electro-Mechanical Systems (MEMS) is the integration of mechanical elements, sensors, actuators and electronics on a common silicon substrate using microfabrication techniques. MEMS are a hot area of research because they integrate sensing, analyzing and responding on the same silicon substrate hence promising realization of complete systems-on-a-chip. As MEMS are manufactured using batch fabrication techniques similar to IC technology, MEMS are expected to deliver high functionality at low prices.
Imagine not being able to have a snack or candy whenever you want to in a day. Many people have to watch what they eat, especially diabetics because of lack of insulin in their bodies. They have to watch their sugar intake daily and also keep up with insulin shots. Diabetes is a life long disease which isn’t easy to have without new technological advancements. The rapid growth of technology has made health care more successful, specifically in the advancements for the cure and treatments of diabetes.