Literature Review on Preterm Birth

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Preterm birth is defined as ‘any neonate whose birth occurs before the thirty seventh week of gestation’1 and represents approximately eight percent of all pregnancies1-4. It is eminent that these preterm infants are at risk of physical and neurological delay, with prolonged hospitalisation and an increased risk of long-term morbidity evident in prior literature3, 5-13. Innovative healthcare over the past thirty years has reduced mortality significantly14, with the survival rate of preterm infants having increased from twenty five percent in 1980 to seventy three percent in 200715. Despite, this drop in mortality long-term morbidity continues to remain within these surviving infants sparking a cause for concern15, 16.
Exposure to an adverse in-utero environment severely impacts child neurodevelopment. At school age, poor neurodevelopment is reflected by reduced general intelligence, poor attention and poor cognitive performance. Poor neurodevelopment across adolescence is a major concern affecting a child’s ability to thrive and reach academic and economic success. Whilst the financial burden due to adverse outcomes of preterm birth differs among families, the economic burden on society remains great. In 2012, the Australian education system spent $220 million dollars to support special learning programs, which included support teachers, improved classroom resources, learning assistance and intervention programs [REFERENCE]. By gaining awareness of the determinants of an adverse fetal environment, suitable intervention programs can be established to aid in reducing the health and economic burden currently seen within society.
1.1 Birthweight and Gestational Age
One concept that holds great significance when examining outcomes...

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...ole? Developmental medicine and child neurology. 2014.
58. Treyvaud K, Doyle LW, Lee KJ, Roberts G, Lim J, Inder TE, et al. Social-emotional difficulties in very preterm and term 2 year olds predict specific social-emotional problems at the age of 5 years. Journal of pediatric psychology. 2012;37(7):779-785.
59. Luciana M, Lindeke L, Georgieff M, Mills M, Nelson CA. Neurobehavioral evidence for working-memory deficits in school-aged children with histories of prematurity. Developmental medicine and child neurology. 1999;41(8):521-533.
60. Curtis WJ, Lindeke LL, Georgieff MK, Nelson CA. Neurobehavioural functioning in neonatal intensive care unit graduates in late childhood and early adolescence. Brain : a journal of neurology. 2002;125(Pt 7):1646-1659.
61. Gardosi J FA. GROW Centile Caculator- GROW-CCC software v5.1. Gestation Network wwwgestationnet Published 2006.

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