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Investigate the effect of antibiotics on bacteria
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Deep within our gastrointestinal tract, known affectionately as the gut, exists a community like no other which helps maintain the essence of who we are and helps us maintain the balance us humans yearn and depend on to live. Bacteria, archaea, protists, fungi and viruses all interact around each other keeping the boring and uneventful that the body likes full of abundance. Upon some sort of shake up whether there are maleficent bacteria charging the intestinal landscape threatening to wipe out the community, or a change in the environment due to movement or destruction of the community members the microbiome’s ability to weather the storm and keep its intestinal home straight is essential. One of these shake ups, in the case of excessive antibiotic use through indirect infection, members of the intestinal microbiome community are wiped out and allow for Clostridium difficile, a normal inhabitant of the gastrointestinal landscape to thrive unchecked by the previous order and create a new dysfunctional world, creating a state of dysbiosis. …show more content…
difficile acts as a gang when there are few bacteria to check them and can cause diarrhea of the watery variety. A method delivered to calibrate the gut called fecal microbiota transplant utilizing fecal matter containing the essential members of the microbiome community to repopulate the barren, dysfunctional land to create a new one retaining order lost. The utilization of fecal microbiota transplant is a worthwhile option upon the inability of first line drugs such as oral vancomycin or metronidazole to work or in pervasive C. difficile infection running ragged in the microbiome, making the patient sick. I believe this is so due to the empirical studies previously done on the intervention and the success associated. In a study done by Kelly et
Clostridium difficile, otherwise known as C. diff, is a species of spore-forming, anaerobic, gram-positive bacteria that is known to cause watery diarrhea. 1 The genus name, Clostridium refers to the spindle shape of the organism while Difficile means difficult in Latin due to the fact that this organism thrives in unfavorable conditions and is very difficult to isolate.4 The incidence of getting CDI has increased over the years due to new strains of increased toxin production of the bacteria and increased resistance to antibiotics.2 It is a gastrointestinal infection, and the most common cause of infectious diarrhea.1 C. difficile was first identified in the feces of healthy newborns back in the 1930’s and by 1935, it was considered normal flora. 2 During 1974, researchers conducted that about 21% of patients that were treated with an antibiotic called clindamyacin reported diarrhea and about 10% of them reported to have conducted pseudomembranous colitis as a side effect of this treatment. 2 It was in 1978 where C. diff had been known to cause anti-biotic associated diarrhea and pseudomembranous colitis. 2 It is known to form spores that resist many disinfectants; it also survives for several months on different surfaces.1 It is a common form of a nosocomial infection and the prevalence of becoming infected with C. diff is about 0-15% in a health care setting. 3 The spores survive well in environments such as soil, water and animals and is distributed worldwide. 4 CDI produces two toxins (Toxin A and B), which are cytotoxic and cause tissue necrosis.4
Often patients encompassing with Clostridium difficile have no symptoms or they may express symptoms of mild diarrhea, pseudomembranous colitis, and inflammation of the colon causing pain (Mitchell, 2014). Clostridium difficile is a bacterial infection of the intestine and it may occur in patients who are immunocompromised or taking broad-spectrum antibiotics. Walter (2014) explains that the most important risk factor for CDI continues to be recent administration of antibiotics. The infection occurs from depression of the normal flora of the bowel through the administration of antibiotics. The depression of the normal flora increases the number of C. difficile bacteria within the intestines. The overgrowth of C. difficile causes diarrhea. Abdominal cramps, fever, and leukocytosis are noted in most patients. Symptoms usually begin 4 to 10 days after the initiation of antibiotic therapy (Elsevier,
According to the article The mechanism and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhea there is a great concern about increasing incidence of C. difficile infection due to use of broad spectrum antibiotics. Clindamycin, third generation of cephalosporins and flouroquinolones are considered high risk antibiotics. It is believed that normal gastrointestinal flora has potential effect in inhibition C.difficile growth and toxin A,B release which offen associated with sever diarrhea resulting in patient’s mortality and other comorbidities. After first episode, there is a high chance for relapses due to reduction serum IgG antibodies to toxin A and colonic IgA secretion cells.
A common hospital acquired condition that nurses see now days is clostridium difficile. This bacterium usually invades patients who have been on long-term antibiotics that have killed off bacteria that protect them from infection. C. diff is passed from host to host by both direct and indirect contact making it readily moved from patient to patient in hospital settings (Mayo, 2013, 1). Nurses can use the QSEN competencies and KSAs to help treat and prevent hospital acquired conditions such as C.diff.
Resistance arises from mutations that are not under the control of humans, but the evolution of bacteria has been sped along by the overexposure of antibiotics to both people and animals. The number of antibiotic-resistant strains of bacteria in an area is closely related to the frequency that antibiotics that are prescribed (Todar, 2012). Patients often unnecessarily demand antibiotics to treat common colds or simple illnesses that are not caused by bacteria. Instead, these infections are caused by viruses which, unlike bacteria, are unaffected by antibiotics. Incorrect diagnosis can also lead patients to using unnecessary antibiotics, which can sometimes be even more dangerous than otherwise left untreated. Besides the fact that antibiotics kill off beneficial bacteria in the intestines, misuse of antibiotics provides an opportunity ...
•The forty five year old patient is diagnosed with the progressive cirrhosis inflaming the liver along with the parenchymal cells. The plain symptoms is manifested primarily because of the augmentation of edema internally in the lower abdomen.
Among hospitalized patients around the world, Clostridium difficile is the primary source of infectious diarrhea. Previously, continuously unbalanced intestinal microbiota, usually due to antimicrobials, was deemed a precondition of developing the infection. However, recently, there have been alterations in the biology from virtually infecting the elderly population exclusively, wherein the microbiota in their guts have been interrupted by antimicrobials, to currently infecting individuals within of all age groups displaying no recent antimicrobial use. Furthermore, recent reports have confirmed critical occurrences among groups previously assumed to be of minimal risk—pregnant women, children, and individuals with no previous exposure to antimicrobials, for instance. Unfortunately, this Gram-positive, toxin-producing anaerobic bacterium is estimated to cost US critical care facilities $800 million per year at present, suggesting the need for effective measures to eliminate this nosocomial infection (Yakob, Riley, Paterson, & Clements, 2013).
*Rohike, F., & Stollman, N. (2012). Fecal microbiota transplantation in relapsing Clostridium difficile infection. Therapeutic Advances in Gastroenterology. 5 (6), 403-419.
Is fecal microbiota transplant (FMT) effective treatment for patients with Ulcerative Colitis (UC). UC is a chronic inflammation of the large intestine. FMT is used to describe the delivery of a healthy donors stool into a patient via enema, colonoscope, or nasogastric tube. In the past several years FMT has been used for an alternative treatment with patients diagnosed with Clostridium difficile (CD). The purpose of this paper is to discuss if FMT is just as effective in treating UC over just medication. The articles below will give insight if this theory is true or not.
Digestion is defined as the process of transforming foods into unites for absorption. The Digestive System is a complex network of organisms that have six major processes: The digestion of food, the secretion of fluids and digestive enzymes, the mixing and movement of food and waste throughout the body, the digestion of food into smaller pieces, the absorption of nutrients, and the excretion of wastes (Inner Body (1).)
The human digestion system is very complex. It starts with the mouth, salivary glands, pharynx, esophagus, stomach, liver, pancreas, gallbladder, small intestine, large intestine, then ends/exits with the anus. Each step is essential to the whole system. For example, the mouth chews food and mixes it with saliva produced by the salivary glands, and then the pharynx swallows chewed food mixed with saliva, this is followed by the food traveling through the esophagus to the stomach where the food gets a bath and mixes with acids and enzymes. After the stomach, the liver, pancreas, and gallbladder produce, stores, and releases bile and bicarbonates. Bile is produced in the liver and aids in digestion and absorption of fat while the gallbladder stores bile and releases it into the small intestine when needed. Following the process into the small intestine, this is where nutrients will be absorbed into the blood or lymph (most digestion occurs here). Next is the large intestine this is where water and some vitamins and minerals are absorbed. Finally, it is the end of the road, the anus. At...
Microbes are microscopic life forms, usually too small to be seen by the naked eye. Although many microbes are single-celled, there are also numerous multi-cellular organisms. The human body has 10-100 trillion microbes living on it, making it one giant super-organism. Since the first link between microbes and diseases was made, people have been advised to wash their hands. Scientists, however, have recently started to investigate more closely how the microbes that call the human body home affect our health. While some microbes cause disease, others are more beneficial, working with our bodies in many subtle ways.
Exposure to antimicrobials fundamentally alters microbial ecosystems of humans, animals and the environment, which may lead to the development of antimicrobial resistance.
The digestive system is a very important system in the human body. It is a group of organs that work together to turn food into energy and nutrients in the entire body. The food that was chewed in a humans’ mouth now passes through a long tube that is inside of the body that is known as the alimentary canal. The alimentary canal is made of the oral cavity, pharynx, esophagus, stomach, small intestines, and large intestines. Those few things are not the only important accessories of the digestive system there is also the teeth, tongue, salivary glands, liver, gallbladder, and pancreas.
Gastroenteritis, sometimes referred to as infectious diarrhoea is a common disease that affects millions of people annually. It is a disease caused by viruses, bacteria or parasites that enter the human body and spread, which induce symptoms such as vomiting, diarrhoea, abdominal pain and nausea. Although it is a common occurrence in society and is usually not harmful, cases of gastroenteritis in less developed countries may have more fatal repercussions due to their inability to access ample means of treatment. Over time, as more research was conducted into the disease, scientific developments were made to aid those affected by gastroenteritis and reduce the number of fatalities by educating people regarding preventative methods.