Egt Task 1

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Subject: Chemistry

Task: ERT (Extended Response Task)

Title: Instrumental Analysis: Response to Stimulus

Name: Lifa Whyte

Date: Friday, 14 August 2015

Teacher’s Name: Mr Lawler

Task 1: High Performance Liquid Chromatography
High Performance Liquid Chromatography (HPLC), also known as High Pressure Liquid Chromatography, is a technique used to separate compounds in mixtures (Clark 2007). HPLC is a type of liquid chromatography and is the separation of molecules in a mobile liquid phase by running them through a solid stationary phase (Bio-Rad Laboratories, 2015).
HPLC is based off Column Liquid Chromatography and involves a number of components: a HPLC column, mobile phase and stationary phase (O’Hanlon Cohrt, 2014). The HPLC column …show more content…

In the technique used, the Methyl Red is in its anionic form so emits a yellow colour. If the food sample injected into the HPLC column has a pH that will cause the indicator to change colour to red, the results will be inaccurate, as the detection system used doesn’t work well for the red wavelengths. One example where this could occur is when finding the cyclamate content of soft drinks which have a pH between 2.0 and 4.0, a range that would change the indicator colour to red, rather than yellow. To prevent this from occurring, solutions entering the column for testing should have their pH changed to a value that will not cause a change in the indicator colour (pH > …show more content…

ppm = mmol/L = = =
Therefore, the lowest value that can be detected by the technique is 28.17mg/kg. The table shows that the lowest permitted level of cyclamate in foods is 400mg/kg. This far exceeds the 28.17mg/kg limit so this value can be detected by the technique, as will all other maximum permitted levels of cyclamate in foods. Because of this, the method will be useful.

Recommendation:
The proposed method of detecting cyclamate can be used when finding cyclamate levels over 28.17mg/kg in foods. Though this is the case, it must be known that the process only picks up between 93 to 99% of cyclamate within a sample, meaning that up to 7% of the cyclamate in a sample may not be detected. For foods containing small amounts of cyclamate this will not have great effect, however foods such as low joule chewing gum will have greater levels of cyclamate undetected.
The indirect HPLC technique suggested can
Although this is the case,

Reference List
Bhanot. D, 2012, High Performance Liquid Chromatography: Module 4, viewed 6/815,
Bio-Rad Laboratories, 2015, Liquid Chromatography Principles, viewed

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