Statement of Purpose
I am apllying for PhD in Immunology at Harvard Medical in order to enrich further my academic knowledge, have access to the best equiped laboratories in the world and work within a highly professional and dedicated scientific community. Particularly, I want to work on identifying new targets for cancer treatment and prevention. All conventional cancer treatment available nowadays, such as chemotherapy, radiotherapy, targeted drugs, anti-angiogenic agents and immune checkpoint blockers require specialized hospitals with expensive equipments, skilled people with a range of knowledge varying from nuclear physics to cell biology. Combination of all these make it impossible for people from small rural villages, like where I grow up, get at least a chance to cure their cancers. My ultimate goal is to develop a simple cancer treatment method which can be delivered by an average educated physician with a needle in his hand. Nowadays, it is not possible yet becuase the biology of cancer cells is not completely understood, particularly we are lacking the knowledge about how our own immune cells interact within tumor microenvironment, and this is the field I want to explore during my PhD studies.
I heard about
…show more content…
I would volunteer in different projects interested in having students in their labs. The greatest chalenge I had during my Bachelor is to combine classes, research, and work, as I had to be able completely support myself financially. I can say that I have succeded in all of these aspects of my life because as a student team, with my other colleques we were able two year in a row participate in highly competitive IGEM international Biology Olympiad with our own designed and conducted research. Second time as a team, we won a Bronze medal in MIT. Moreover, my final semester GPA was 4.0 and I was officially employed by my University throughout of my Bachelor
Memorial Sloan Kettering Cancer Center (MSKCC) has impacted the world nationally and internationally for their involvement and work with cancer, science, research, and medicine. A goal of Memorial Sloan Kettering Cancer Center (MSKCC) is through extensive research and training explore new ways to treat, cure, and control cancer on a national and worldwide level. Scientist and Researchers affiliated with MSKCC take their knowledge, investigation, and research to create clinical trials, studies and new treatments for cancer nationally and worldwide which create various economic opportunities throughout the nation and world.
The AMGEN Summer Scholars research experience will contribute to my plans to become a M.D./Ph.D. candidate, and ultimately an Oncologist, by helping me develop critical and independent thinking as well as creative skills as they relate to the field of medicine. It will also help me develop a more thorough understanding of biological concepts, how they directly apply to medical treatment, and the ways in which biotechnology fuses multiple fields of science to create technologies to care for others. The opportunity to assist in creation of the technologies that will be used on my future patients will ultimately improve my ability to treat their illnesses in adaptive ways. The opportunity I would have to read, interpret, and be a part of creating
The main idea of this study is to underscore: "the need to validate potential cellular targets for adjuvant and systemic therapies on disseminated cancer cells directly"( Cancer Cell: July 2003).
U.S. Congress, Office of Technology Assessment. 1990. Unconventional Cancer Treatments, OTA-H-405. Washington, D.C.: U.S. Government Printing Office.
Breast cancer has always been a common thread among the women of my family; especially on my mother’s side, including my Grandmother whom passed away due to this disease before I could ever meet her. More so, my mother was gravely affected by this disease early in my life. Thankfully, she was able to stop the cancer from spreading; the doctors were able to find the cancerous cells and remove them. Due to this grave, but powerful impact on my life, I have been determined to becoming a biomedical scientist to assist on the research and treatment of this deadly disease. Although this acts as my principal driver, to study in this field, I have also been intrigued and driven by the idea that I could aid lower setting regions to receive health benefits using studies in translational medicine and
...y may be another area of research that may enhance anti-tumor activity. Creating better antibodies, like rituximab and others we are able to better target the tumor cell. There are many targets on our bodies immune cells and by being able to locate them specifically and boost the immune system in order for it to work better than it already can proves to be beneficial and harnessing this power can lead to a dramatic impact on the way we treat cancer. Maintaining and preserving patients quality of life and looking for lifelong cure is what scientists are looking for. Improving the efficacy of these immunotherapy treatments can lead to significant breakthroughs including longterm remission and being able to treat patients with cancer that is hard to treat. I look forward and can't wait to see the advances that will be made in this field or research in the near future.
All human bodies have an immune system, which is a complex network of cells and organs that protect the body from germs and other foreign substances. A mistake can make the body unable to tell the difference between foreign substances and the body’s own cells. When this happens, the body makes auto-antibodies that attack body cells by mistake. When a foreign substance invades your body (like a cold virus or bacteria on a thorn that pricks your skin) your immune system attacks it. It tries to identify, kill and get rid of the invaders that might harm you. But sometimes problems with your immune system cause it to mistake your body’s own healthy cells as invaders and then repeatedly attack them. This is called an autoimmune disease.
Cancer in one way or another touches all of us, whether as a patient or through the diagnosis of the people you love around you. Millions of patients who are faced with cancer are depending on oncologists everywhere to cure cancer so others will not suffer like they had to. Optimistically, sooner rather than later this international problem will come to an end. There are a number of drug companies that have been coming out with cancer treatment drugs. “Oncology has been one of the hottest and most active therapeutic areas for drug development, drug makers may want to take note of a finding that new cancer drugs have proven far more difficult to gain approval than medicines for infectious and autoimmune diseases.” (nature.com) Unfortunately, these drugs cannot cure the cancer but it sure makes it a load easier o...
Almost everyone is touched by cancer in some way and the number of people living with and beyond cancer grows greater every year. Globally 14 million people are diagnosed with cancer each year and 8 million people will die from it annually. Half of all men and one-third of all women will develop cancer during their lifetime. (13) There are many treatments for cancer, mainly: surgery, radiation and chemotherapy. These traditional treatments have many negative side effects. Therefore, increasingly, other treatments, such as hormonal therapy and targeted therapy are being used for certain cancers. Nanotechnology is a form of targeted therapy that destroys cancer tumors with minimal damage to healthy tissues and organs. Scientists are already using nanotechnology in early detection of elimination of cancer cells before they form tumors. But the real game changer will be when nanotechnology targets cancer tumors in treatment (11,13).
The immune system has the important job of protecting the body from foreign invaders. It is made up of a network of cells (including white blood cells), tissue and organs. The foreign invaders the immune system fight include viruses, bacteria, microbes and pathogens. In order to stop these foreign invaders, there is a process known as immune response that attacks in three different lines of defence. Without this immune response, the body would be constantly under invasion by pathogens trying to attack and induce illness.
Childhood vaccinations have received a lot of media in the past few years, and parents continue to question whether or not they should have their children vaccinated. This topic is a very important issue because it seems to be a trend in our society where parents are not vaccinating their children. This then leads their children becoming more susceptible to unnecessary diseases/viruses that can be prevented with vaccines. The focus of the following articles was on the association of the specific vaccines measles, mumps, and rubella (MMR), and vaccines containing thimerosal, which has been a speculated reason for the cause of autism. This contentious hypothesis has many parents failing to vaccinate their children; this is especially true of many friends and family members of mine. They believe that vaccines can cause autism, and I want to prove otherwise.
“Since 1990, over 6 million Americans have died of cancer, more than the combined casualties from the Civil war, WWII, and the Vietnam and Korean conflicts combined” (Faguet, p. 5). According to American Cancer Society projections, there were 1,529,560 new cases of cancer in 2010. Cancer is becoming more and more common around the world. New cancers are constantly being discovered. Researchers are finding new ways to detect cancer and treat it so that the fatality rate does not rise. However, there are some cancers that researchers have not yet discovered a cure for. It is very important for Cancer Research to continue so that one day these cancers will no longer be a treat.
One of the most common mysteries in the world is the development of autoimmune diseases. An autoimmune disease is when the immune system, which usually keeps your body healthy thinks that your healthy cells are antigens and attacks them. This is irony right? It is against properties of evolution for an immune system to attack itself causing sickness and possibly death if untreated. There are about 80 different types of autoimmune diseases, which usually have periods of little to no symptoms and worsening symptoms. What particularly creates confusion in the world is the autoimmune disease, inflammatory bowel disease, which affects almost about five million people worldwide.
Cancer is the uncontrolled growth of abnormal cells in the body. Tumors are then created and interfering with the digestive, nervous and circulatory systems. It is one of the most leading causes of death, reaching at about 8.2 million deaths in 2012. It is expected that cancer will rise from 14 million to 22 million within the next 2 decades. With over 100 cancer research centers in the United States studying how to treat this disease, people need to understand the importance of donating also with the awareness of signs and symptoms in the early stages. But, what are we doing about it? Do we have the technology to finally be able to put this deadly disease to an end?
Our immune system protects our bodies from pathogens like bacteria and viruses very efficiently in most cases. One big question that has come up is why does the immune system not respond to cancerous cells in the same way? Why are cancer cells not eradicated like other dangerous foreign cells? This seems very strange, especially since the immune system has cells that are specific to destroying cancer cells and virus-infected cells, called natural killer cells. To begin to answer this question it is useful to examine cancer cells and their interactions with the immune system in more detail.