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About Tissue engineering
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Types of Tissue Engineering As known by now, Tissue Engineering is the combination of the cell, engineering material and suitable biochemistry factors that are used to improve the biological functions. There are 4 types of Tissue Engineering, mainly which are Autograft, Isograft, Allograft and lastly Xenograft. Firstly, autograft is said to be a graft from one area to another area of the same individual, such as in the transplantation of normal skin from one area to another burned area of the same individual. This type of graft is recognised as autologous, which means self, and this type of graft does not produce any immune responses. Autograft can be summarised as a transplant that is occurring on the same individual. Moving on to the second type, Isograft or also commonly known as syngraf in which, is a graft of tissue that is transplanted from one individual to another individual that are syngeneic. Syngeneic in this pretext is said to be both the individuals are genetically identical. In general, genetically identical individual are said to be identical twins. For an example,...
...ograft. If the graft comes from someone who has died, it is called an allograft. Doctors have tried using some types of synthetic grafts but so far these have not worked well. Research is being done to see if there are better types of grafts that can be used.
The term “medical transplant” is referred to the process of organ donation. In current modern trends, the world is moving towards the fifth generation. The new innovative medical techniques have enabled the people to reform from severe diseases. The phenomenon of organ donation and transplant is based on two primary persons. It involves surgical process to remove a body organ and tissue form from donor and fitting it into the body of recipient. In addition, the transplant that is performed within same body is called auto graft. Medical transplant that is performed in between to different bodies of same species is called allografts (Hewitt, 2008). The main reason of medical transplantation and organ donation is any injury and disease which prohibit the organ to work in proper condition.
The major practical issue to be surmounted with any transplant is immunological. For a transplant to be successful the transplanted tissue must not...
This paper focuses on the benefits of stem cell research in the medical and nursing field. New technology is always being created to help us understand the way the human body works, as well as ways to help us improve diseased states in the body. Our bodies have the ability to proliferate or regrow cells when damage is done to the cells. Take for example the skin, when an abrasion or puncture to the skin causes loss of our skin cells, the body has its own way of causing those cells to regrow. The liver, bone marrow, heart, brain, and muscle all have cells that are capable of differentiating into cells of that same type. These are called stem cells, and are a new medical tool that is helping regrow vital organs in our body to help us survive. Stem cells can come from adult cells, or the blastocyst of the embryo. The cells that come from these are undifferentiated, and can be specialized into certain cell types, making them available for many damaged tissues in the body. While using stem cells in the body is a main use, they are also being used to help doctors understand how disease processes start. By culturing these cells in the lab and watching them develop into muscles, nerve cells, or other tissues, researchers are able to see how diseases affect these cells and possibly discover ways to correct these diseases. While researchers have come very far in using stem cells, there are still many controversies to overcome when using these cells.
The field of bioprinting, using 3D printing technology for producing live cells with extreme accuracy, could be the answer to many of the problems we as humans face in the medical field. It could be the end to organ waiting lists and an alternative for organ transplants. In 3D printing technology lies the potential to replace the testing of new drugs on animals. However, the idea of applying 3 dimensional printing to the health industry is still quite new and yet to have a major impact. Manufacturing working 3D organs remains an enormous challenge, but in theory could solve major issues present today.
Biomedical engineering is a branch of science that connects engineering sciences with biological sciences that started around the 1940s (Citron & Nerem, 2004). Biomedical engineering is the discipline that promotes learning in engineering, biology, chemistry, and medicine. The objective for biomedical engineers is to enhance human health by incorporating engineering and biomedical sciences to solve problems. Some of the accomplishments made from biomedical engineering are prosthetics, robotic and laser surgery, implanted devices, imaging devices, nanotheranostics and artificial intelligence. As we head towards the future, biomedical engineering is anticipated to become an even greater part of the medical industry and bring about innovating
Xenotransplantation is the process of taking cells, parts of organs, or even whole organs from one species of animal, and implanting them into another species. The FDA has given their own definition of xenotransplantation which they say is “any procedure that involves the transplantation, implantation, or infusion into a human recipient of either live cells, tissues, or organs from a non human animal source, or human body fluids, cells, tissues or organs that have had ex vivo contact with live non human animal cells, tissues or organs.” The main interest of the practice is to be able to take organs from animals for the purpose of using them in humans in need of organ transplants. It is still a relatively new medical phenomena, with documented cases of the practice only taking place since 1906.
Over the past few years scientists have been using cloning and genetic engineering. Cloning is the action of copying an organism’s (e.g. human) DNA and replicating it. This will give you exact twins. Genetic engineering is the process of adding new DNA to an organism manually. This is to add genes that were not in the organism originally. These two have some similarities but are not that alike. Most people make a fuss over both subjects saying it’s not right while others think it is an advance in technology and very useful. I am not fond of the ideas and think they can lead to big problems in our life.
An allograft is either bone, cartilage, tissue, ligament, tendon or any section of the skin that is donated from another person that is deceased. Allografts do contain osteoconductive scaffolds with minimal osteoinductive factors. A disadvantage of Allografts is the risk of bacterial contamination or the possibility of viral transmission diseases such as hepatitis and human immunodeficiency5. Jorgenson et al.6 Conducted a prospective analysis in lumbar fusion of allografts versus autografts in the same patient and concluded that an ethylene oxide-treated allograft is inferior to an autograft and should not be used for posterior lumbar fusions(Level II). Further, An et al.7conducted a prospective comparison of autografts and allografts for adult posterolateral lumbar spinal fusion and reported that autografts resulted in significantly greater bone density, followed by the mixture of autografts and allografts, frozen allografts, and freeze-dried allografts (Level II). These reports indicate that allografts alone were not able to achieve a sufficient fusion rate for posterior spinal fusion in the adult
Skin is particularly rich in stem cells because so much skin is lost through normal wear and tear; you shed thousands, sometimes even millions, of dead skin cells every day. In mild cuts and burns, stem cells work to repair the damaged tissue. But in severe burns the stem cells in the burn area are destroyed, so doctors have to take skin from an undamaged area. The biggest obstacle in performing a skin graft is that, currently, only the burn patient’s own skin works reliably. If doctors try to use skin from another person, the patient’s immune system will eventually reject the graft. However, scientists are working on ways to grow skin that’s genetically compatible with the patient so that, even if the patient doesn’t have enough undamaged skin to use, the burns can still be treated
In the twin study method, researchers studies identical twins (monozygotic twins) and fraternal twins (dizygotic twins) to determine how much they resemble each other on a variety of characteristics. Identical twins have exactly the same genes because a single sperm cell of the father fertilizers a single egg of the mother, forming a cell that then splits and forms two human beings-"carbon copies." But fraternal twins are no more alike genetically than any two siblings born in the same parents. In the case of fraternal twins, two separate sperm cells fertilize two separate eggs that happen to be released at the same time during ovulation.
The connective tissue is the most abundant and widely distributed in complex animals. It is made up of a matrix consisting of living cells and non-living substance called ground substance. The ground substance is made of an organic substance (protein) and an inorganic substance (usually a mineral or water). It separates the cells and varies in consistency from solids to semifluid to fluid. The principal cell of connective tissue is the fibroblast which makes the fibers found in nearly all connective tissues. There are three kinds of fibers; the white collagen fibers contain collagen, a protein that gives them flexibility and strength. Reticular fibers are very thin collagen fibers that are highly branched and form delicate supporting networks. The yellow elastic fibers contain elastin; a protein that is not as strong
While doctors were stumped by transplanting blood from one person to another, others continued forward. In 1869, the first skin transplant occurred. Then, in 1906 they conducted the first transfer of corneas. Once everyone was finding that certain relocations of body parts was working they moved onto the moving of organs. The first successful kidney transplant was in 1954 and it was between identical twins. Next, in 1959, doctors completed another kidney transplant once again twins but this time they weren’t identi...
The idea of organ transplants has been around for centuries, tracing back to myths by ancient Greeks and other early civilizations but people were unable to perform any surgeries for many years because they did not have the right technology and science to keep someone alive with a transplant. In the 1700’s, a Swiss naturalist, Abraham Trembley, observed the powers of organ regeneration in a tiny pond animal he called the hydra but could not do much with the information he gathered (Markovitz 98). It was in the early 1900’s when doctors started to try transplanting organs from one living thing to another. During this time, European doctors had patients dying of renal failure. In order to save them, they transplanted kidneys from different animals into them such as monkeys, pigs, and goats. Unfortunately, they were not successful and the patients never lived for more than a few days. Though organ transplants had not been successful, in 1905, Eduard Zirm, an Austrian ophthalmologist, was able to perform the world’s first corneal transplant. The procedure gave sight to a man who had been blinded in an accident. It was a good start to human transplants, but they were still a long way away. “In 1912, Alexis Carrell received a Nobel Prize for his work in the field. The French surgeon had developed methods for connecting blood vessels and conducted successful transplants on d...
Researchers in this field are seek to know how stem cells can be used to develop into specialized cells or tissue, which aims restore lost function in damaged organs or even grow new fully functioning organs for transplant.