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Pathophysiology of diabetic neuropathy
Effect Of Glucose In The Body
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DIABETES MELLITUS
Diabetes Mellitus occurs when the pancreas is unable to produce a hormone called insulin to regulate metabolism. Without insulin the glucose (a sugar in the blood) cannot enter cells of the body and blood glucose levels will rise, resulting in Hyperglycemia. There are various forms diabetes; type one and type two diabetes and gestational diabetes, which is diabetes while being pregnant, or impaired glucose tolerance (IGT) or homeostasis, IGT is a pre-diabetic state of hyperglycemia that is associated with insulin resistance. Pre-diabetic patients with IGT have blood glucose levels that are high but they are not high enough to be diagnosed with diabetes yet. Lifestyle changes can help to reduce the IGT patients risk of developing diabetes mellitus these include; exercising regularly, limiting sugar and carbohydrate intake and
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Neuropathy occurs more with clients who have been diabetic for a long time. After years of excessive amounts of glucose the walls of tiny blood vessels can be damaged, these blood vessels usually nourish your nerves and when damaged can longer give nourishment causing neuropathy. When nerves don't function correctly they can no longer send messages to the brain to warn against dangers such as heat or cold causing the client with diabetic neuropathy the inability to sense being burned or temperatures that are too cold. Keeping blood glucose levels at a normal range can help in delaying the onset of diabetic neuropathy. The longer a client has diabetes and the more out of control the blood sugar is the risk for diabetic retinopathy increases. Retinopathy can develop in any one with type one or type two diabetes. According to the Mayo Clinic it is caused by damage to the blood vessels of the light sensitive tissue at the back of the eye (retina). In the beginning the client may experience no symptoms at all, but over time diabetic retinopathy can cause
Although there are many symptoms for Diabetes, many people fail to see the signs or they choose to ignore them. One sign is frequent urine output, this is caused by high amounts of glucose in the urine. Too much urine output can then lead to dehydration, leading to increased thirst. A human with early signs of diabetes may also experience an increase in appetite and fatigue. The Fluctuations in glucose level can even lead to blurred vision. Some of these signs may not seem too serious at first but when left untreated it can lead to even bigger symptoms such as infections in the gums, skin, bladder or even vaginal areas. It also effects the healing process of the body, sores that normally wouldn’t take long to heal can take more than twice the time normally needed. In more serious cases ...
According WebMD 2014. Diabetes mellitus (or diabetes) is a chronic, lifelong condition that affects your body's ability to use the energy found in food. There are three major types of diabetes. Type 1 diabetes mellitus, type 2 diabetes mellitus and gestational diabetes. It is a hormonal disorder of the pancreas either decrease in insulin level also known as hypoinsulinism or increase in insulin level also known as hyperinsulinism. Lowered amounts, insufficient of, or ineffective use of insulin leads to the disorder of diabetes mellitus. It is common chronic disease requiring lifelong behavioral and lifestyle changes. According to Peakman (2012). The development of type 1 diabetes mellitus is a genetic and an autoimmune process that results in destruction of the beta cells of the pancreas, leading to absolute insulin deficiency. There is usually a pre-diabetic phase where autoimmunity has already developed but with no clinically apparent insulin dependency. Insulin autoantibodies can be detected in genetically predisposed individuals as early as 6-12 months of age. In persons genetically susceptible to type 1 diabetes, a triggering event, possibly a viral infection the leads to production of autoantibodies that kill the beta cells and results in decline and a lack of insulin secretion. According to Wherrett. It is caused by impaired insulin secretion and insulin resistance and has a gradual onset. Those with type 2 diabetes may eventually need insulin treatment. Gestational diabetes mellitus is glucose intolerance during pregnancy in a woman not previously diagnosed with diabetes, this may occur if placental hormones counteract insulin, causing insulin intolerance. Complications in diabetes mellitus includes: Hypoglycemia it is ca...
The pathophysiology of diabetes mellitus in is related to the insulin hormone. Insulin is secreted by cells in the pancreas and is responsible for regulating the level of glucose in the bloodstream. It also aids the body in breaking down the glucose to be used as energy. When someone suffers from diabetes, however, the body does not break down the glucose in the blood as a result of abnormal insulin metabolism. When there are elevated levels of glucose in the blood, it is known as hyperglycemia. If the levels continue to remain high over an extended period of time, damage can be done to the kidneys, cardiovascular systems; you can get eye disorders, or even cause nerve damage. When the glucose levels are low in one’s body, it is called hypoglycemia. A person begins to feel very jittery, and possibly dizzy. If that occurs over a period of time, the person can possibly faint. Diabetes mellitus occurs in three different forms - type 1, type 2, and gestational.
Well how can you get it? Well it’s caused by damaged blood vessels in the tissue that the retina which is located at the back of the eye. When blood sugar levels are too high for extended periods of time, it can damage capillaries which are tiny blood vessels that supply blood to the retina. Over time these blood vessels begin to leak fluids and fats, causing edema. Then the vessels can close off which is called ischemia. These types of signs are non-proliferative diabetic retinopathy (“Diabetic Retinopathy Treatment,”2016).
Diabetes is a metabolic disease where the body is unable to produce any- or enough- insulin which causes high glucose levels in return. There are 3 different types of diabetes that people are most familiar with. Type 1 diabetes, which is an autoimmune disease where that person would need insulin from the second they’re diagnosed. Type 2 diabetes, which may take months or even years for a person to require insulin. With type 2 diabetes, the affected person is usually older and overweight. The third type that people are most familiar with is Gestational diabetes. GD occurs during pregnancy. Around 28 weeks gestation, the pregnant woman is instructed to go for a one hour glucose test to check for diabetes. Usually after the pregnancy, the diabetes goes away- although there are some cases where it doesn’t.
Diabetes is a disease in which a person’s body in unable to make or utilize insulin properly which affects blood sugar levels. Insulin is a hormone that is produced in the pancreas, which helps to regulate glucose (sugar) levels, break down carbohydrates and fats, and is essential to produce the body’s energy. The CDC (2013) offers reliable insight, summarized here, into the different types of diabetes, some causes, and health complications that may arise from the disease.
Diabetes is a disease that affects the body’s ability to produce or respond to insulin, a hormone that allows blood glucose (blood sugar) to enter the cells of the body and be used for energy. Diabetes falls into two main categories: type 1, or juvenile diabetes, which usually occurs during childhood or adolescence, and type 2, or adult-onset diabetes, the most common form of the disease, usually occurring after age 40. Type 1 results from the body’s immune system attacking the insulin-producing cells in the pancreas. The onset of juvenile diabetes is much higher in the winter than in the summer. This association has been repeatedly confirmed in diabetes research. Type 2 is characterized by “insulin resistance,” or an inability of the cells to use insulin, sometimes accompanied by a deficiency in insulin production. There is also sometimes a third type of diabetes considered. It is gestational diabetes, which occurs when the body is not able to properly use insulin during pregnancy. Type 2 diabetes encompasses nine out of 10 diabetic cases. Diabetes is the fifth-deadliest disease in the United States, and it has no cure. The total annual economic cost of diabetes in 2002 was estimated to be $132 billion, or one out of every 10 health care dollars spent in the United States. Diabetes risk factors can fall into three major categories: family history, obesity, and impaired glucose tolerance. Minority groups and elderly are at the greatest risk of developing diabetes.
Diabetes mellitus type 2 is an endocrine disorder that causes impaired use of carbohydrates while enhancing the use of proteins and lipids. This is called insulin resistance, in which the pancreas cannot make enough insulin to keep blood glucose levels normal, or the body is unable to use what is produced. The impairment causes blood glucose level to rise higher than normal. There is no cure for type 2 diabetes mellitus and it is life threatening when left untreated. Signs and symptoms of this disorder include vision changes, increased thirst, increased hunger, increased frequency of urination, stomach pain, nausea and vomiting, erectile dysfunction, and absences of mentruation. These can occur abruptly, or over a long period of time. Long-term complications from diabetes include kidney damage, eye damage, and blindness. The risk factors for developing diabetes mellitus include genetics, sedentary lifestyle, high blood pressure, history of diabetes during pregnancy, poor diet, obesity, high cholesterol, and abdominal obesity. Diabetes mellitus can be managed through the use of medication, or by reducing risk factors, such as avoiding obesity, inactivity, and poor nutrition.
...in sources of energy. When cells cannot absorb sugar, you can become fatigued or feel exhausted” (Healhline), complain of blurred vision” In the short term, high glucose levels can cause a swelling of the lens in the eye. This leads to blurry vision. Getting your blood sugar under control can help correct vision problems. If blood sugar levels remain high for a long time, other eye problems can occur” (HealthLine), experience nocturia “Elevated glucose levels force fluids from your cells. This increases the amount of fluid delivered to the kidneys. This makes you need to urinate more. It may also eventually make you dehydrated” (Healthline), and have sores and cuts that will not heal “Elevated glucose levels may make it harder for your body to heal. Therefore, injuries like cuts and sores stay open longer. This makes them more susceptible to infection” (HealthLine).
Gestational diabetes mellitus (GDM) is an intolerance of glucose documented for the first time during pregnancy. It is usually a short-term type of diabetes and the most common health problem with pregnant women. GBM is caused by the way the hormones in pregnancy affect the mother. GDM accounts for 5-7% of all pregnancies (American Diabetes Association, 2010). During pregnancy the placenta develops and becomes the main bond between the mother and the baby. It is used to make sure the baby has and gets enough nutrients. The placenta makes several hormones which make it hard for insulin to control blood glucose and block the action of the mother’s insulin in her body (American Diabetes Association, 2010). Hormonal changes during the pregnancy causes the body to be less sensitive to insulin. Insulin has the job of opening up the cells so that the glucose can get inside regulating the amount of glucose in the blood while glucose is the amount of sugar in the blood stream. In pregnancy, the body needs to make three times more insulin for control of the blood sugar. GDM is usually found within the second trimester of a pregnancy and increases until the end of the pregnancy. Usually within a few hours of delivery the condition resolves itself (American Diabetes Association, 2010).
Diabetic Neuropathy is a group of neurological disorders caused by nerve damage resulting from the effects of type one and type two diabetes. There are several types of neurological diseases, each affecting the individual differently. Each disorder presents with its own symptoms, prognosis, and risks. It is important for the diabetic patient to receive adequate education from their physician on the basic signs and symptoms of neuropathy. Early identification and frequent check-ups can greatly impact the effects of neuropathy.
With any diseases, there are many risk for patients later in life, some of T1 Diabetics being things like diabetic neuropathies or nerve pain, kidney disease, and even eye disease. The diabetic neuropathies usually come later in life, in adulthood, and can be described as a pain, tingling sensation, or numbness in the hands, arms, feet, or legs. This pain is caused by the buildup of high blood sugar which damages nerves and blood cells. In some, the symptoms may not be noticeable until years later, and in others the severity of the pain is quite sudden. Peripheral neuropathy, the most common of nerve pain, is characterized by affecting the feet and legs and on occasion hands and arms. Symptoms include burning, tingling, numbness, weakness,
“Diabetes mellitus (sometimes called "sugar diabetes") is a condition that occurs when the body can't use glucose (a type of sugar) normally. Glucose is the main source of energy for the body's cells. The levels of glucose in the blood are controlled by a hormone called insulin, which is made by the pancreas. Insulin helps glucose enter the cells” (Diabetes Mellitus).
Diabetes mellitus is a group of metabolic disorders which is characterized by hyperglycemia due to insulin deficiency or resistance or both reasons. (1) According to that diabetes mellitus can be divided as type I and type II. This is common and its incidence is rising, 171 million people had diabetes in 2000 it is expected this condition to be doubled in 2030. It is spread in all the countries and therefore has become a major burden upon healthcare facilities. (2)
Diabetes Mellitus is a disease in which the pancreas produces little or no insulin. Insulin is a hormone that helps the body’s tissues absorb glucose which is sugar, so it can be used as a source of energy. Glucose levels build up in the blood and urine which causes excessive urination, thirst, hunger, and problems with fat and protein metabolism in a diabetic person. Diabetes is very common in the United States; it is the seventh leading cause of all deaths. Women have been diagnosed with diabetes more than men. There are two forms of diabetes, Type one and Type two diabetes. Type one diabetes is when the body does not produce insulin or produces it in very small quantities. This usually occurs in younger people under twenty years of age, mostly around puberty. Type two diabetes is when the body’s balance between insulin production and the ability of cells to use insulin doesn’t work properly. This is more common than type one; about 90-95% people in the United States have it. There are no cures for diabetes now but there are many researchers investigating factors through new technologies to cure them. Meanwhile, technological advancements are being made to keep glucose at a good level for diabetes.