My passion for Science started with chemistry. The elixir of life mentioned in the book “Crucibles: The story of chemistry” by Bernard Jaffe, made a profound impression on me. During my diploma in chemical engineering, I was introduced to physiology and biochemistry by reading books of my roommate. I realized the potential implications of these fields of study upon the riddle of the Elixir of Life,‘how to prevent aging and to extend lifespan.’
Fittingly, I chose biotechnology as my undergraduate major. During my bachelor’s, I worked on three major projects. First, a genetic engineering project to enhance Pyocyanin production in Pseudomonas aeruginosa by overexpressing Phenazine gene; second, In-silico screening for Resveratrol (known
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Never reluctant, I shared my ideas for solving problems to the high-level management with relevant references and experimental design. At SeraCare, I currently work as a Process Engineer and received several accolades. I polished several transferable skills like statistical data analysis, the design of experiments, and literature mining during my tenure at SeraCare. My penchant for academic research never waned, my four years at SeraCare has helped me validate my interest in academic research as my career path. After graduation, I continued to read scientific communications to keep me abreast of research developments and decided that my broad research focus will encompass cancer immunotherapy. In future study and research, I would like to empower myself on two main components:
(I) Understand the factors/pathways involved and their crosstalk in the tumor microenvironment leading to immunosuppression and diminished clinical
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Reading publications of Dr. Michail Sitkovsky from Northeastern University has helped me to visualize, how A2AR mediated mechanism prevents T effector cell infiltration into the tumor milieu and limit the success of adoptive cell transfer and checkpoint blockade therapies. The research findings at the Spranger lab implicated, cancer intrinsic Wnt/β-catenin pathway in CD103+ dendritic cells as a cause for immunosuppression in the tumor microenvironment. The absence of T effector cell infiltration, decrease in INF-γ and CXCL9 and increase in proliferation of T regulatory cells have been the unifying theme of both Wnt/β-catenin and A2AR mediated immunosuppression. The research work at the Spranger's lab fits my interest and inspires me with a question of crosstalk between the two immunosuppressive mechanisms. Strengthening my inquiry, a recent publication of Dr.Bruce Cronstein from the New York University has reported a crosstalk between Wnt/β-catenin pathway and A2AR in dermal fibroblasts. Pharmacological blockade of A2AR inhibited the Wnt/β-catenin pathway by inhibiting the nuclear translocation of β-catenin, and A2AR activation resulted in increased cellular β-catenin levels. Also, adding weight Dr. Michail Sitkovsky’s group has reported A2AR expression in dendritic
The focus of Miller’s The Crucible is an appalling witch trial that morfs the once-peaceful town of Salem into a cutthroat slaughterhouse. As a lucrative playwright and a not-so-subtle allegory author, Miller is a seasoned wordsmith who addresses people akin to himself, and is not secretive about that information. The Crucible best serves its purpose as a learning device and a social statement, especially at the time of its publishing. Miller‘s piece showcases the appeals in an easy-to-identify manner that is perfect for middle or high school students who are new to the appeals, or for English majors who have no problem pinpointing them, making this play ideal for a classroom setting.
Common sense seems to dictate that we are all going to die one day. As we all get older we crave to keep our youth, and to stay young forever is the ultimate dream. The thought of a possible immortality is just an added benefit. Even though we have strived towards this goal for centuries, have we obtained advances in successfully staying young forever? In Bill Gifford’s book “Spring Chicken: Stay Young Forever (Or Die Trying)” he explores these ideas of life and aging further. In this novel, he goes on a journey to try and debunk the mysteries and questions behind the new science of aging. He gathers information from tests and scientists from around the country to discover what really works to prevent or delay aging and what is just a hopeful hoax. He helps us figure out why we age and why aging
Quote Analysis: Miller tells us that Reverend Parris, “like the rest of Salem, never conceived that the children were anything but thankful for being permitted to walk straight, eyes slightly lowered, arms at the sides, and mouths shut until bidden to speak.” Children in Salem were expected to be happy and content with the strict theocratic society they live in. When Abigail and the other girls were found disobeying puritan laws and dancing naked in the forest, it was outrageous and unbelievable that they would rebel against the laws.
Personal character traits are the attitudes you have toward your activities and the challenges they present. These traits may be positive, negative or often in between, depending on the situation. Many negative character traits were depicted in Arthur Miller’s The Crucible. He discussed the guilt of personal private sin, loss of emotional control and the worst of all jealousy. Negative personal character traits can lead to failure or frustration. These characteristics will affect you throughout your life. The story revolves around Salem, Massachusetts in 1692. The author converses about witchcraft and displays many issues in the town of Salem. These above traits are still found in our times because we don’t live in an ideal society.
Arthur Miller’s political allegory of McCarthyism, in the form of The Crucible, has been adapted into a faithful companion to the play that is able to incorporate the emotions and atmosphere that may not have been available to some in the play. Miller’s screenplay is very faithful to the book, having many of the same lines and situations the character in the play experience. Because of this, we are able to make an active connection to the play, thus expanding our understanding of the play. Lead by Daniel Day-Lewis, The Crucible’s plot is portrayed by a solid cast, who, for the most part, are able to engross the viewer into the story. The film contains many captivating scenes that exemplify hysteria meant to be depicted in the play, that demands the viewers attention while also immersing them in emotions. The film adaptation of The Crucible is a well produced version of the play that not only serves as a companion to the play, but an entertaining and though provoking experience.
The Crucible – Characters and Changes & nbsp; Change is good for the future. " We hear the catchy phrase everywhere. From company slogans to motivational speeches, our world seems to impose this idea that change is always a good thing. Assuming that the change is for the better, it is probably a true statement in most cases. The root of this idea seems to come from the notion that we are dissatisfied with the state that we are in, so, in order to create a more enjoyable environment, we adjust.
In the novel The Crucible, by Arthur Miller, highlights a powerful drama based on the chaotic Salem Witch Trials. Salem is governed strictly where the bible is the law and anyone who doesn 't follow the law must be acquainted with the Devil. Witchcraft started by a group of girls getting caught "dancing in the woods" (Trevino). In Salem, dancing was prohibited and the girls knew they were in trouble so without thinking twice they started accusing others of being seen with the Devil. The main character in Salem is John Proctor that portrays the classic tragic hero who falls to his death. This allowed the reader to fully understand that he is a honorable, simple, virtue, and "sinner" man (Miller 19). In his lifetime, he runs into trouble with Abigail that ruined his relationship with God, his wife Elizabeth, and also damaged his self image. We see the external conflict that Miller illustrates with John and the Salem Witch Trials that is examined on his use of two tools: plot and characterization.
In The Crucible, Arthur Miller tells a story that is based off the real Salem witch trials. The tragic hero in this story is John Proctor and he is married to Elizabeth Proctor. John Proctor has three boys. His tragic flaw is his affair with Abigail Williams (she is one of the girls that lead the witch trials as one of the “victims”). John Proctor and Abigail William’s affair is what led to Abigail Williams wanting to be his wife, then the witch trials, thus leading to his death.
In conclusion, the acting in the production was very good. I was held captivated by the accents and shocked by the language and dialect because I knew that this really happens and has happened. I felt like I could actually change what was happening on stage. For Instance, when the rumble is happening and Bernardo and Riff bring out the switchblades, I gasped. Silently to myself, I said "DON'T DO THIS. THIS WAS SUPPOSED TO BE A CLEAN FAIR FIGHT. YOU GUYS ARE MORE SIMILAR THAN YOU ARE DIFFERENT, JUST BEING FRIENDS." The same occurrence happened when Anita is assaulted by the Jets when attempting to find Tony to save him. I understood her feelings and wanted the Jets to get in trouble for their actions. I became invested in what happened to the
Arthur Miller’s The Crucible takes place in Salem, Massachusetts in 1692. During this time period, Salem is in hysteria due to the witch hunts and trials of the seventeenth century. The hysteria of the witch trials paints a picture of Good vs Evil which makes The Crucible a morality play. Furthermore, Miller intended to create his characters this way in order for people to reflect on their current way of life. Specifically, the Red Scare that was taking place when the play was first released.
Pretend you are Arthur Miller, who just finished writing his play on the Salem witch trials called “The Crucible”. Wait, why did you pick the name crucible out of all the names in the world for your play. What does that word mean, well Webster's dictionary defines a “crucible” as being, “a container in which metals are heated, involving a change." and "a severe test or trial.” Now knowing what it means, why do you know why you picked the word crucible for your the play?
The Crucible is a famous play written by Arthur Miller in the Early 1950’s. It was written during the “Red scare, when McCarthyism was established. Many anti-communists wanted to prevent communism from spreading just like in The Crucible many wanted to get rid of witchcraft. Many would accuse others of witchcraft in order to not be accused just like many would accuse people of communism. In The Crucible witchcraft would be punishable by death. Many were scared to be accused; therefore many would admit practicing witchcraft in order to save their lives. The Crucible is considered a good play because it is based on real life events during the Salem witch Trials and shows how fear played a role in the individual’s life just like during the “Red” scare.
The quiet before the storm If anything is a perfect example of the quiet before the storm, it would be this small village before the chaos. Not many like to hear about the past of this little village in eastern Massachusetts;they all just want to hear about the commotion. What they do not understand is that sometimes to understand the present, you have to analyze the past. Some people haven’t looked close enough.
The Wnts are secreted glycoproteins that makes a large family of nineteen proteins in humans hinting to a daunting complexity of signaling regulation, function and biological functions. To date major signaling branches downstream of the Fz receptor have been identified including a canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway which can be further divided into the Planar Cell Polarity and the Wnt/Ca2+ pathways, and these branches are being actively dissected at the molecular and biochemical levels. (Komiya & Habas,
This can trigger cytotoxic T cells to kill cancer cells with the same antigen – often HPV viral proteins in cervical cancer. T cells may not be activated to their full potential – recall that the inhibitory receptor CTLA-4 in T cells sends a stronger signal than CD28, the activating receptor.