Sox17 Sy Gene Essay

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Sox17 SRY gene The SRY-box containing gene 17 (Sox17) was discovered less than a decade ago as a member of the high mobility group (HMG) transcription factor super family. (Zhang et al., 2008) Sox genes are known by a DNA sequence encoding an almost 80 amino acid domain that is responsible for sequence specific DNA binding. Within the Sox family, there are at least 30 members that are expressed in different tissues, cell types, and stages within development. There are seven groups of Sox genes that are classified on their amino acid sequence and genomic structure. Sox17, Sox7, and Sox18 are in the Sox group F. Genes are grouped into this family if they contain HMG domain levels with strong amino acid similarities to the HMG domain of SRY. The SoxF subgroup has a critical role in the differentiation of different cell types, which includes visceral and definitive endoderm and hematopoietic cells. The SoxF subgroup is needed for proper cardiovascular development. Sox17, Sox7, and Sox18 are expressed in endothelial cells during development. (Corada et al., 2013)
Sox Groups in Mouse and Human
SoxA: SRY
SoxB1: Sox1, Sox2, Sox3
SoxB2: Sox14, Sox21
SoxC Sox4, Sox11, Sox12 …show more content…

The Wnts are secreted glycoproteins that makes a large family of nineteen proteins in humans hinting to a daunting complexity of signaling regulation, function and biological functions. To date major signaling branches downstream of the Fz receptor have been identified including a canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway which can be further divided into the Planar Cell Polarity and the Wnt/Ca2+ pathways, and these branches are being actively dissected at the molecular and biochemical levels. (Komiya & Habas,

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