Bipolar Cell Research Paper

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Abstract
Bipolar cells serve as the bridge cell between the photoreceptor cell and the ganglion cell that located in the INL and span from the OPL down towards the IPL of the retina. Like the photoreceptor cell it also must transduce a chemical signal in order to signal ganglion cells or amacrine cells. The transduction pathway in the bipolar cell is different from the photoreceptor transduction pathway in that there are two distinct bipolar cells that do not use photons as the trigger but instead the neurotransmitter glutamate that is activated by hyperpolarization of the photoreceptors. ON-bipolar cells are depolarized by a central stimuli to the receptive field that is position in the center while OFF-bipolar cells are hyperpolarized by …show more content…

Within the retina lay different cells capable of handling and directing different pathways. From the photoreceptors, to horizontal cells, bipolar cells, amacrine cells, and the ganglion cells. Of these cells it is the bipolar cell which conducts visual signals to the brain using parallel ON-Center and Off-Center pathways (4). The pathways these signals travel from the bipolar cells are considered ON when depolarized and when OFF are hyperpolarized. In the mammalian retina metabotropic glutamate receptors (mGluRs) are associated with the ON pathway and ionotropic glutamate receptors (iGluRs) are associated with the OFF pathway …show more content…

The implication for this occurrence is that glutamate must block a certain cation-permeable channel keeping the cell continuously depolarized (7). The mGluR6 couples to heterotrimeric G protein complex, known as GO. For phototransduction to occur the GOα ¬ complex must be able close the non-selective melastatin-related transient receptor-1 (TRPM1) cation-channel at the moment when activation of the ON bipolar cell occurs (8). The mechanism of exactly how this complex was able to close the cation-channel was unknown until recently. The dominant α subunit of the G¬O is Gαo and Gαo2 has been noted to help during the ON polar light response (9). Furthermore, Gβϒ in the latest studies in many signaling processes has shown to act differently with different effectors giving array to a multitude of assembly and movement of receptor based signaling complexes (9). Because of Gβϒ there has been signaling mechanisms based on G-proteins range that has increased its

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