Belimumab Research Paper

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Sadly, this world is majorly affected by disease. It tears families apart, ruins lives, and brings pain to the affected. This long list of life-destroying diseases includes systemic lupus erythematosus, or SLE. “[SLE] is a multisystemic, autoimmune disease of unknown etiology, which affects multiple organ systems, including the central nervous system, or CNS” (Milovancevic et al.). This disease will literally turn a person’s body against itself. It leads to a lot of pain in the victim. The optimistic side of this coin, however, tells us that many pharmacologists, over time, have created medications that can also nullify the effects of the symptoms. This includes a list of medications, such as antimalarial drugs, non-steroidal anti-inflammatory …show more content…

“Belimumab has been shown to suppress autoantibodies in people with lupus. It was approved in 2011 as the first drug created specifically for lupus in 50 years. Though it has shown to be helpful, further research is needed to determine its long-term effectiveness” (Ludham). Because they have not gotten more information on it, it is rarely used. However, from what we do know, it works well for SLE patients. Also, when they made research trials, they found that “In both trials the proportion of patients responding to therapy was significantly higher in the belimumab 10 mg/kg group than in the placebo group. There was no statically significant difference in response rate between patients receiving belimumab 1 mg/ kg and placebo” (Goldfinger and …show more content…

“No disease more dramatically illustrates the body's capacity to turn on itself than systemic lupus erythematosus (SLE). This is the prototypical example of the immune system gone awry, manufacturing antibodies that can injure and sometimes even destroy vital organs such as the kidneys, brain, and heart” (Goldfinger & Cotton). Numerous doctors have depended vigorously on treatment with cortisone-like steroids because they are guided by the idea that SLE's "protean indications" result from tissue aggravation created by a misrepresented insusceptible reaction. These medications regularly bring fast and emotional change in patients with exceptionally troubling indications (Goldfinger and Cotton). This information shows us that these fast acting drugs do wonders against SLE's symptoms by practically eliminating them. When these people develop emotional problems, such as depression, it can also stop them from having these thoughts of distress and sadness. Comparatively speaking, the effects of these drugs are practically nothing in comparison to the horrible symptoms of SLE.

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