Wait a second!
More handpicked essays just for you.
More handpicked essays just for you.
Don’t take our word for it - see why 10 million students trust us with their essay needs.
Recommended: History
Biochemistry of Nucleic Acids and Recombinant
Introduction
The following essay will outline the 1983 Nobel Prize winner Paul Berg, for his studies of the biochemistry of nucleic acids and recombinant-DNA. The reason why I chose Paul Berg as my Nobel Laureate was because his findings won him the Nobel Prize in the field of Biochemistry. Since he won the prize for Biochemistry, his findings will cover both Biology and Chemistry, which will help me in two of my NCUK courses. In the essay, a discussion consisting of Berg’s biography, research, and the science behind his winning will be covered. Also, a summary of the essay and a critical evaluation will be discussed.
Discussion
Biography
Paul Berg was born on June 30, 1926 in New York, USA (Encyclopedia Britannica, 2013). He graduated from Pennsylvania State College, and later received his doctorate from Western Reserve University. With his extensive educational background, Berg continued his studies at the Institute of Cytophysiology (study of physiology of cells) in Copenhagen, and at Washington University in St. Louis (Encyclopedia Britannica, 2013). He then later worked for Stanford University Medical School where he conducted his research that lead him to the Nobel Prize (Encyclopedia Britannica, 2013). After he won the Nobel Prize, Berg set up an organization called the Asilomer Conference, which discussed the hazards and harms involved with recombinant DNA (Berg, 2004). The conference concluded that there are very little to no hazards invlolved with recombinant DNA (Berg, 2004).
Research
Paul Berg created the first recombinant DNA molecule by combining genes from different organisms. Recombinant DNA is a DNA molecule created by joining various DNA seque...
... middle of paper ...
...2013. Paul Berg (American Biochemist). [online] Available at: http://www.britannica.com/EBchecked/topic/61698/Paul-Berg [Accessed: 21 Feb 2014].
Immunization Action Coalition. n.d. Historic Dates and Events Related to Vaccines and Immunization. [online] Available at: http://www.immunize.org/timeline/ [Accessed: 23 Feb 2014].
Medical News Today. 2013. Discovery of Insulin. [online] Available at: http://www.medicalnewstoday.com/info/diabetes/discoveryofinsulin.php [Accessed: 23 Feb 2014].
Princeton University. n.d. DNA ligase. [online] Available at: https://www.princeton.edu/~achaney/tmve/wiki100k/docs/DNA_ligase.html [Accessed: 23 Feb 2014].
Shapiro, L. J. and Cederbaum, S. 1984. Recombinant DNA in Medicine. Western Journal of Medicine, 141 (2), p. 210. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1021739/ [Accessed: 10 Feb 2014].
DNA Timeline: DNA Science from Mendel to Today. (2014). Retrieved May 29, 2014, from http://www.dnai.org/timeline/
This would lead to a very slow and painful death. In 1922, four Canadian researchers by the names of Frederick G. Banting, Charles H. Best, John J.R. MacLeod, and James B. Collip had discovered a way to separate insulin in the pancreas of dogs and prepare it in such a way so that it can be used to treat diabetic patients. In the year 2008, there were 1,656,470 people who suffered from diabetes in Canada, and by 2010, it is predicted that this disease will take over the lives of 285 million people. Although there is no cure for diabetes, the treatment of prepared insulin is prolonging the lives of diabetics and allowing them to live freely. The discovery of insulin was important and significant in Canada’s history because Banting was a Canadian medical scientist who had a purpose in finding a treatment for diabetes, its discovery has saved lives and improved the quality of life of those suffering from this disease, and it showed the world Canada’s medical technology was extremely advanced....
Frederick Banting, with the help of Charles Herbert Best, J.R.R. Macleod and James Bertram Collip, was able to isolate insulin from animals and treat patients suffering from diabetes, using injections of the insulin. The insulin injections succeeded in treating diabetes.
Insulin is by far the most influential discovery in Canadian and world history. In Canada in 2008/2009 there were 2.4 million people living with diabetes and there are many more today. With out the discovery of insulin many people would not be able to live full lives. However, the discovery of insulin was not just an accomplishment Fredrick Banting and his colleagues had developed in the 1920s, it was a product of timing and luck on Banting’s part and the idea that he took from others was the product that changed the century.
Atkinson, William. Epidemiology and Prevention of Vaccine-Preventable Diseases. Washington: Centers for Disease Control and Prevention, 1996.
Altman, Lawrence K. “For 3 Nobel Winners, a Molecular Mystery Solved.” The New York Times. The New York Times, 7 Oct. 2013. Web. 1 Dec. 2013.
"The discovery of the structure by Crick and Watson, with all its biological implications, has been one of the major scientific events of this century." (Bragg, The Double Helix, p1) In the story of The Double Helix, James Watson tells of the road that led to the discovery of life's basic building block-DNA. This autobiography gives insight into science and the workings within a professional research laboratory that few members of society will ever be able to experience. It also gives the reader an idea of the reality of life for one scientist and how he struggled with the problem of DNA. However, the author's style is marked by his lack of objectivity and inclusion of many biased opinions and personal prejudices.
The first evidence of diabetes was found on an early Egyptian manuscript from 1500 BCE, however; it is only in the last 200 years that we understand what is happening at the cellular level in a diabetic individual (Polansky, 2012). We now know that diabetes is a complex disorder of genetic, chemical, and lifestyle factors that contribute to the body’s inability to utilize glucose for energy and cellular functions (ADA, 2013).
Family: Immunizations for Children. Immunizations for Children, 26 Nov. 2012. Web. The Web. The Web.
In Pauling’s own words he was “…a physicist with an interest in chemistry. [His] scientific work, however, has not been restricted to chemistry and physics, but has extended over X-ray crystallography, mineralogy, biochemistry, nuclear science, genetics, and molecular biology; also nutrition and various aspects of research in medicine, such as serology, immunology, and psychiatry” (Marinacci Ed., 1995, p. 26). Pauling received two Nobel Prizes acknowledging his contributions, one in Chemistry in 1954 and one for Peace in 1962.
Watson, J. D., Gilman, M., Witkowski, J., Zoller, M. (1992). Recombinant DNA. New York: W. H. Freeman and Company.
Although humans have altered the genomes of species for thousands of years through artificial selection and other non-scientific means, the field of genetic engineering as we now know it did not begin until 1944 when DNA was first identified as the carrier of genetic information by Oswald Avery Colin McLeod and Maclyn McCarty (Stem Cell Research). In the following decades two more important discoveries occurred, first the 1953 discovery of the structure of DNA, by Watson and Crick, and next the 1973 discovery by Cohen and Boyer of a recombinant DNA technique which allowed the successful transfer of DNA into another organism. A year later Rudolf Jaenisch created the world’s first transgenic animal by introducing foreign DNA into a mouse embryo, an experiment that would set the stage for modern genetic engineering (Stem Cell Research). The commercialization of genetic engineering began largely in 1976 wh...
According to M.R. Pollock, the true hazard of recombinant DNA is the technology falling into the hands of irresponsible individuals or communities. He explains that this is possible because it is very easy for detailed explanations of scientific techniques to spread all over the world. However, the major concerns in his time are about the escape of dangerous and out-of-control recombinant DNA. Pollock argues that although these concerns are warranted, they are not the most important and if scientists only worry about taking maximum precautions in their laboratories, the danger of improper exploitation of the technology of recombinant DNA would still lie. Pollock aims to raise awareness on the history of humans and how we have handled inventions
Discoveries in DNA, cell biology, evolution, and biotechnology have been among the major achievements in biology over the past 200 years with accelerated discoveries and insight’s over the last 50 years. Consider the progress we have made in these areas of human knowledge. Present at least three of the discoveries you find to be the most important and describe their significance to society, heath, and the culture of modern life.
Mccoy, K. The History of Diabetes - Diabetes Center - Everyday Health. 2009. Web. 14 Mar 2014 .